Gut-Associated Biomarkers L-FABP, I-FABP, and TFF3 and LIT Score for Diagnosis of Surgical Necrotizing Enterocolitis in Preterm Infants

Ng, Eddy Wing Yin; Poon, Terence Chuen Wai; Lam, Helena; Cheung, Hon Ming; P.Y., Terence; Chan, Kathy Yuen Yee; Wong, Raymond Pui On; Leung, Kam Tong; Lam, Melody M. T.; Li, Karen; Ng, Pak Cheung

doi:10.1097/sla.0b013e318288ea96

Cited by 81 publications

(104 citation statements)

References 25 publications

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“…In the present study we obtained samples of plasma and urine in regular intervals of 8 h. This method is in contrast to other publications, in which analyses of single, daily or 24-hour samples of plasma and/or urine are reported [2,4,5,12,13,14,19,20,21], with the one exception being the study of Edelson et al [3]. The obvious advantage is gaining an insight into the clinical course of the disease and associated I-FABP levels.…”

Section: Discussionmentioning

confidence: 57%

“…This gives the clinician the opportunity to select the best possible way to measure I-FABP. Although several studies report on I-FABP measured in plasma [3,4,19] and serum [20], and several others on the use of urinary I-FABP measurements [5,12,13,14], no literature compares both methods. Several positive and negative aspects of both measuring methods can be identified.…”

Section: Discussionmentioning

confidence: 99%

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Intestinal Fatty Acid-Binding Protein in Neonates with Imminent Necrotizing Enterocolitis

Schurink¹,

Scholten²,

Kooi

et al. 2014

Neonatology

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Background: Intestinal fatty acid-binding protein (I-FABP) is a promising marker for necrotizing enterocolitis (NEC). It can be measured in plasma (I-FABPp) and urine (I-FABPu). Data on the best way to measure I-FABP (in plasma or urine) and the necessity of simultaneous measurement of the urinary creatinine concentration to correct for physiological variations in urine concentration are not available. This holds also true for the reciprocal relation between I-FABPp, I-FABPu and other more conventional laboratory parameters. Objectives: To evaluate the above-mentioned correlations of I-FABP measurements in neonates with suspected NEC. Methods: All neonates with suspected NEC were prospectively included. I-FABPp and I-FABPu were analyzed at regular intervals during the first 24 h after onset of symptoms. Correlation and agreement were assessed between these and other parameters (i.e. IL-6, WBC, platelet count, CRP, pH and lactate). Results: Included were 24 boys, 13 girls [median (range) GA 28 weeks (24-36), median birth weight 1,190 g (570-2,400)]. I-FABPu correlated strongly with I-FABPp (r 0.80, p < 0.001) with an adequate agreement. A very strong correlation between I-FABPu and I-FABPu/urine creatinine ratio (r 0.98, p < 0.001) existed. Correlations between I-FABPp/u and conventional parameters were moderate to strong until 8 h after onset of symptoms. Conclusion: In neonates with suspected NEC, I-FABPu correlates strongly with I-FABPp, offering an opportunity to choose the most appropriate way of measuring I-FABP. Calculating urinary IFABP/creatinine ratio seems redundant. Moderately strong correlations between I-FABPu and IL-6, WBC and lactate were found.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Intestinal Fatty Acid-Binding Protein in Neonates with Imminent Necrotizing Enterocolitis

Schurink¹,

Scholten²,

Kooi

et al. 2014

Neonatology

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“…C-reactive protein, white blood cell and platelet counts have been used quite commonly, but these do not specifically represent NEC if they are abnormal [54]. Biomarkers for diagnosis under study include intestinal fatty acid-binding protein, claudin 3, calprotectin and IL-8 [54,55,56,57]. Use of these appears to be promising, but exactly how they will be utilized in the clinical setting remains to be seen.…”

Section: Diagnostic Considerationsmentioning

confidence: 99%

Necrotizing Enterocolitis: The Mystery Goes On

Neu

2014

Neonatology

123

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Necrotizing enterocolitis (NEC) has largely been present in neonatal intensive care units for the past 60 years. NEC prevalence has corresponded with the continued development and sophistication of neonatal intensive care. Despite major efforts towards its eradication, NEC has persisted and appears to be increasing in some centers. The pathophysiology of this disease remains poorly understood. Several issues have hampered our quest to develop a better understanding of this disease. These include the fact that what we have historically termed ‘NEC' appears to be several different diseases. Animal models that are commonly used to study NEC pathophysiology and treatment do not directly reflect the most common form of the disease seen in human infants. The pathophysiology appears to be multifactorial, reflecting several different pathways to intestinal necrosis with different inciting factors. Spontaneous intestinal perforations, ischemic bowel disease secondary to cardiac anomalies as well as other entities that are clearly different from the most common form of NEC seen in preterm infants have been put into the same database. Here I describe some of the different forms of what has been called NEC and make some comments on its pathophysiology, where available studies suggest involvement of genetic factors, intestinal immaturity, hemodynamic instability, inflammation and a dysbiotic microbial ecology. Currently utilized approaches for the diagnosis of NEC are presented and innovative technologies for the development of diagnostic and predictive biomarkers are described. Predictions for future strategies are also discussed.

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“…Studies have indicated that the scores for neonatal acute physiology-perinatal extension-II and metabolic derangement acuity were insufficient measures for deciding on surgical treatment for the patients affected by NEC (8). A study from Hong Kong found that the intestinal trefoil factor (ITF) 3 level was higher in NEC patients than in non-NEC patients, suggesting that NEC affects ITF production (9). ITF is a member of the trefoil family and may protect the mucosa from insult, stabilize the mucus layer, and affect healing of the epithelium (10).…”

Section: Introductionmentioning

confidence: 99%

Intestinal trefoil factor increased the Bcl-2 level in a necrotizingenterocolitis neonate rat model

Xiao-jun

Wang

et al. 2016

Turk J Med Sci

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Gut-Associated Biomarkers L-FABP, I-FABP, and TFF3 and LIT Score for Diagnosis of Surgical Necrotizing Enterocolitis in Preterm Infants

Cited by 81 publications

References 25 publications

Intestinal Fatty Acid-Binding Protein in Neonates with Imminent Necrotizing Enterocolitis

Intestinal Fatty Acid-Binding Protein in Neonates with Imminent Necrotizing Enterocolitis

Necrotizing Enterocolitis: The Mystery Goes On

Intestinal trefoil factor increased the Bcl-2 level in a necrotizingenterocolitis neonate rat model

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