Gums‐Based Bionanostructures for Medical Applications

Munir, Hira; Bilal, Muhammad; Khan, Muhammad Imran; Iqbal, Hafiz M.N.

doi:10.1002/9781119711414.ch18

Cited by 9 publications

(3 citation statements)

References 54 publications

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“…Those with marine origin are alginate, agar, and carrageenan. Those from animals (chitin, chitosan, hyaluronic acid, and chondroitin sulphate) and from plants are seed gums (locust bean, guar, cellulose and amylase), tree exudates (gum arabica, tragacanth, gum ghatti, karaya), tubers (starch), and extracts (pectin, larch gum, roots) [ 42 , 43 ].…”

Section: Gumsmentioning

confidence: 99%

Exploring the Antioxidant Potential of Gellan and Guar Gums in Wound Healing

Dodi,

Sabau,

Crețu

et al. 2023

Pharmaceutics

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It is acknowledged that the presence of antioxidants boosts the wound-healing process. Many biopolymers have been explored over the years for their antioxidant potential in wound healing, but limited research has been performed on gum structures and their derivatives. This review aims to evaluate whether the antioxidant properties of gellan and guar gums and wound healing co-exist. PubMed was the primary platform used to explore published reports on the antioxidant wound-healing interconnection, wound dressings based on gellan and guar gum, as well as the latest review papers on guar gum. The literature search disclosed that some wound-healing supports based on gellan gum hold considerable antioxidant properties, as evident from the results obtained using different antioxidant assays. It has emerged that the antioxidant properties of guar gum are overlooked in the wound-healing field, in most cases, even if this feature improves the healing outcome. This review paper is the first that examines guar gum vehicles throughout the wound-healing process. Further research is needed to design and evaluate customized wound dressings that can scavenge excess reactive oxygen species, especially in clinical practice.

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Section: Gumsmentioning

confidence: 99%

Exploring the Antioxidant Potential of Gellan and Guar Gums in Wound Healing

Dodi,

Sabau,

Crețu

et al. 2023

Pharmaceutics

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“…The term "gum" identifies exudates or slims, which are not part of the vegetable cell wall, also known as polysaccharide hydrocolloids [3]. The biocompatibility, low risk of adverse effects, low cost, and their environmentally friendly processing are among the advantages attributed to natural gums [4,5]. Natural gums have been traditionally used as clarifying and gelling agents, emulsifiers, thickeners, and stabilizers in the food industry [6].…”

Section: Introductionmentioning

confidence: 99%

On the Unique Morphology and Elastic Properties of Multi-Jet Electrospun Cashew Gum-Based Fiber Mats

Grumi,

Prieto,

Furtado

et al. 2024

Polymers

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This study investigates the unique morphology and mechanical properties of multi-jet electrospun cashew gum (CG) when combined with high-molecular-weight polyethylene oxide (PEO) and glycerol. Cashew gum (CG) is a low-cost, non-toxic heteropolysaccharide derived from Anacardium occidentale trees. Initially, the electrospinnability of aqueous solutions of cashew gum alone or in combination with PEO was evaluated. It was found that cashew gum alone was not suitable for electrospinning; thus, adding a small quantity of PEO was needed to create the necessary molecular entanglements for fiber formation. By using a single emitter with a CG:PEO ratio of 85:15, straight and smooth fibers with some defects were obtained. However, additional purification of the cashew gum solution was needed to produce more stable and defect-free straight and smooth fibers. Additionally, the inclusion of glycerol as a plasticizer was required to overcome material fragility. Interestingly, when the optimized formulation was electrospun using multiple simultaneous emitters, thicker aligned fiber bundles were achieved. Furthermore, the resulting oriented fiber mats exhibited unexpectedly high elongation at break under ambient conditions. These findings underscore the potential of this bio-polysaccharide-based formulation for non-direct water contact applications that demand elastic properties.

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“…Polysaccharide gums have been the subject of extensive research because of their availability, biodegradability, and biosafety, and they are one of the most commonly used commercial raw materials. 8 Due to their wide range of uses and characteristics, natural gums are used in pharmaceuticals, in solid dosage formulations, they serve as a binder and a disintegrating agent. They act as suspending, thickening, emulsifying, and stabilizing substances in liquid and topical products.…”

Section: Introductionmentioning

confidence: 99%

Design and evaluation of moringa gum-based hydrogel dressings for cutaneous wound healing

Iqbal,

Chatha,

Chauhdary

et al. 2023

Journal of Bioactive and Compatible Polymers

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The study aimed to evaluate moringa gum (MG) and carboxymethyl moringa (CMG) for their possible use in hydrogel-based dressings to treat cutaneous wounds. Initially, MG was characterized for its physical, functional, morphological, and thermal properties. The MG and CMG have shown limited toxicity as indicated by hemolytic assay where values were less than 2.5%. Furthermore, these samples also showed antimicrobial potential. The antioxidant potential of MG was slightly greater than its carboxymethyl derivative. Afterward, MG and CMG were encapsulated in sodium alginate-based hydrogel films. These films showed good physical attributes necessary for the end application. These films were tested in an open wound model in rats. The MG containing films showed the highest % wound contraction on the 10th day, that is,79.42 ± 0.46 with low levels of IL6 and TNF alfa. Out of MG and CMG films, the native moringa gum-based thin film showed comparatively higher potential for wound healing and in the future could be a potential candidate for wound healing dressings.

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Gums‐Based Bionanostructures for Medical Applications

Cited by 9 publications

References 54 publications

Exploring the Antioxidant Potential of Gellan and Guar Gums in Wound Healing

Exploring the Antioxidant Potential of Gellan and Guar Gums in Wound Healing

On the Unique Morphology and Elastic Properties of Multi-Jet Electrospun Cashew Gum-Based Fiber Mats

Design and evaluation of moringa gum-based hydrogel dressings for cutaneous wound healing

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