Gum ghatti-based biodegradable and conductive carriers for colon-specific drug delivery

Evaluation of a conducting interpenetrating network based on gum ghatti-g-poly(acrylic acid-aniline) as a colon-specific delivery system for amoxicillin trihydrate and paracetamol

“…9-12). 29 It has been observed that the release of amoxicillin trihydrate through Gg-g-poly(MAA) and Gg-g-poly(MAA-IPN-aniline) increases with the increase in pH. It is clear from Fig.…”

“…[29][30][31][32] During the initial stages of the release, a high concentration gradient between the hydrogel surface and the release medium plays an important role. [29][30][31][32] During the initial stages of the release, a high concentration gradient between the hydrogel surface and the release medium plays an important role.…”

“…4,7,29,36 This means that the crosslinked hydrogels based on Gg are reliable drug delivery devices for colon-targeted drug delivery systems. It is evident from Tables 3 and 4 that the release profile of amoxicillin trihydrate and paracetamol drugs is greater at pH 9.2 (the pH of the colonic fluids) as compared to that at pH 2.4 and pH 7.0.…”

Hydrogels based on starch‐g‐poly(sodium‐2‐acrylamido‐2‐methyl‐1‐propane sulfonate‐co‐methacrylic acid) as controlled drug delivery systems

“…The high drug release in the basic medium as compared to acidic and neutral medium can be attributed to the COOH groups present in MAA portion of the hydrogels and their pH dependent ionization. Under lower pH, most of the COOH groups are in the protonated state, resulting in the collapse of the cross‐linked hydrogels matrix . At higher pH, the ionization of COOH groups results in higher repulsion between the COO − ions of MAA which expands the polymer chains leading to higher swelling.…”

“…Though PAMPSNa can undergo dissociation completely in the entire pH range , by varying its concentration it is possible to increase the swelling capacity of the hydrogels due to the presence of large number of ionic groups. Hydrogels based on methacrylic acid (MAA) with the ionizable carboxylic groups, can either swell or collapse when subjected to various external stimuli such as pH, ionic strength, electric field, temperature and chemical environment, and any such stimulant can be used to deliver drugs in a controlled manner to specific sites of gastrointestinal tract . Natural materials when grafted with such monomers have shown good mechanical strength.…”