Guillain Barre Syndrome following delivery in a pregnant woman infected with SARS-CoV-2

Abstract

Effects of SARS-CoV-2 on the neurological system have been investigated. Evidence of Guillain-Barre Syndrome (GBS) cases associated with SARS-CoV-2 infection have recently been reported. A 34-yearold multiparous woman with COVID-19 infection at her 37th (4/7) gestational week was presented here. She was diagnosed with Guillain Barre Syndrome at postpartum. As we know recently this was the first case mentioned in the literature. The clinical course of GBS with COVID-19 after childbirth may be similar to GBS patients not infected with COVID-19.

Neurological complications of COVID-19 and spontaneous abortion in a pregnant woman – A case report

“…Guillain-Barré syndrome have been reported in other post-viral infections including influenza, Zika, SARS-CoV, MERS-CoV, and SARS-CoV-2 [3] . It was also reported in a pregnant and postpartum woman with COVID-19 [4] , [5] . Herein, we report the clinical presentations, management and outcome of SARS-CoV-2 associated Guillain-Barré syndrome in a pregnant woman admitted at BYL Nair Charitable Hospital (NH), a dedicated COVID-19 hospital in Mumbai, India.…”

SARS-CoV-2 associated or post partum Guillain Barre syndrome?

“…The main shortcoming of the study is that a causal relation between SARS-CoV-2 and GBS was postulated (first part of discussion) without providing evidence for such a relation [1]. In the discussion it is already mentioned that pregnancy and more frequently the post-partal period can be complicated by GBS [1,2]. GBS during pregnancy has been shown to resolve rapidly during the post-partial period [3].…”

“…With interest we read the article by Tekin et al about a 34yo female who was tested positive for SARS-CoV-2 in her 37th week of pregnancy [1]. She manifested clinically with mild COVID-19 (coughing) one day before admission and underwent Cesarean section under general anesthesia on hospital day-2 [1]. Eighteen days after clinical onset of COVID-19, the patient developed dysphagia, limb muscle weakness, and urinary hesitancy.…”

“…Eighteen days after clinical onset of COVID-19, the patient developed dysphagia, limb muscle weakness, and urinary hesitancy. Two days later Guillain-Barre syndrome (GBS) subtype acute, motor and sensory axonal neuropathy (AMSAN), was diagnosed and intravenous immunoglobulins (IVIGs) were given with a beneficial effect such that MRC improved from 1 to 3 in the lower limbs and from 4 to 5 in the upper limbs [1]. The study is appealing but raises the following comments and concerns.…”

The Current Evidence Regarding COVID-19 and Pregnancy: Where Are We Now and Where Should We Head to Next?

“…Moreover, the impact of SARS-CoV-2 on the neurological system has been emphasized, as the virus’s neurotropism potential has been in the spotlight of research. Some cases of Guillain–Barre Syndrome associated with COVID-19 have been recently revealed [ 13 , 61 ].…”