Neurological complications of COVID-19 and spontaneous abortion in a pregnant woman – A case report

Mahajan, Niraj N.; Srivastava, S.; Chakor, Rahul T; More, Prajakta; Mahale, Smita D.; Gajbhiye, Rahul

doi:10.1016/j.ejogrb.2021.06.010

Cited by 5 publications

(20 citation statements)

References 6 publications

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“…Three of the pregnant women with GBS developed early neurologic symptoms, 30 , 31 , 32 and all investigated cases presented typical features of GBS. 30 , 31 , 32 , 33 …”

Section: Discussionmentioning

confidence: 88%

“…Finally, we reviewed 18 case reports from the selected 17 papers (Tables 1 and 2 ). 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 …”

Section: Resultsmentioning

confidence: 99%

“…Peripheral nervous system involvement was reported in nine cases 19 , 29 , 30 , 31 , 32 , 33 , 34 , 35 (Table 2 ): GBS 29 , 30 , 31 , 32 , 33 ( n = 5), among which, one case also presented vestibular neuritis 33 ; Bell's palsy 19 , 29 , 34 ( n = 3); and rhabdomyolysis 35 ( n = 1).…”

Section: Resultsmentioning

confidence: 99%

“…The first symptoms of GBS developed during the first week of COVID‐19 in three cases 30 , 31 , 32 and after the first month in 2 cases. 29 , 33 One patient was diagnosed with GBS with no further investigations, 29 while all the other four cases had been investigated.…”

Section: Resultsmentioning

confidence: 99%

“…Two cases had undergone brain and spinal cord imaging exams, which proved to be unremarkable. 32 , 33 All four patients underwent complementary investigations: the CSF analysis demonstrated no cells, 30 , 31 normal 33 or increased 32 cell counts, along with elevated 30 , 33 or normal 31 , 32 protein levels; the CSF of two cases was tested for SARS‐CoV‐2 with a negative result 30 , 33 ; nerve conduction studies demonstrated signs of generalized polyradiculoneuropathy 30 , 31 , 32 or mononeuropathies 33 with predominantly demyelinating pattern 31 , 32 , 33 and axonal loss. 30 , 31 , 32 A nerve biopsy was performed, which, in one case, ruled out vasculitis.…”

Section: Resultsmentioning

confidence: 99%

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Pregnancy and neurologic complications of COVID‐19: A scoping review

Magalhães

Rocha-Filho

2022

Acta Neuro Scandinavica

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While neurologic complications are frequently reported among patients with COVID‐19 in the general population, they are unknown in pregnant women. This paper summarizes the case reports of pregnant women with confirmed SARS‐CoV‐2 infection plus a specified neurologic diagnosis. Until November 2021, 18 case reports were found. Both the central and peripheral nervous systems were equally affected: delirium ( n = 1), posterior reversible encephalopathy syndrome ( n = 4), cerebrovascular disease ( n = 2), acute cerebral demyelinating disease ( n = 1), acute necrotizing encephalopathy ( n = 1), Guillain–Barré syndrome ( n = 5), including one patient who also had vestibular neuritis, Bell's palsy ( n = 3), and rhabdomyolysis ( n = 1). The median maternal age was 32.5 (25—35) years, the median gestational age was 34 (30—36.5) weeks, and 38.9% presented previous medical conditions. Respiratory symptoms were reported in 76.5%, and 76.5% received immunotherapies to treat the COVID‐19 or the neurologic complications. Half the women required admission to ICU and, more often, were those with central nervous system involvement (77.8% vs. 22.2%; Chi‐square test, p = .018). For 64.7% of women, the most common method of delivery was surgical, although just one case was due to the neurologic complication. There were reports of one spontaneous abortion, two fetal deaths, and no maternal deaths. Only one case presented a poor neurologic outcome. It is possible that our findings are underestimated, considering that there are thousands of reports regarding neurologic complications in the general population with COVID‐19.

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“…Three of the pregnant women with GBS developed early neurologic symptoms, 30 , 31 , 32 and all investigated cases presented typical features of GBS. 30 , 31 , 32 , 33 …”

Section: Discussionmentioning

confidence: 88%

“…Finally, we reviewed 18 case reports from the selected 17 papers (Tables 1 and 2 ). 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Pregnancy and neurologic complications of COVID‐19: A scoping review

Magalhães

Rocha-Filho

2022

Acta Neuro Scandinavica

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Impact of COVID-19 pandemic on maternal and neonatal outcomes: A narrative review and evidence from the PregCovid registry

Zala

Munshi

Mahajan

et al. 2023

JRHM

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More than 533 million Coronavirus Disease 2019 (COVID-19) cases and associated 6 million fatalities were reported globally whereas 43 million cases and 0.5 million deaths in India were reported till June 2022. Maharashtra state alone reported about one-third of the total cases of COVID-19 in India in the early period of COVID-19 pandemic. The lack of epidemiological, demographic, and impact data of COVID-19 on pregnant women and newborns, advocated the need for recording and documenting population specific data for clinical management and policy decisions in India. The PregCovid registry was launched in April 2020 by the Indian Council of Medical Research-National Institute for Research in Reproductive and Child Health, Mumbai, in collaboration with the Medical Education and Drugs Department, Government of Maharashtra, and Topiwala National Medical College and Bai Yamunabai Laxman Nair Charitable Hospital to gain insights into clinical and socio-epidemiological characteristics of pregnant women with lab confirmed COVID-19 and assess its impact on maternal and neonatal outcomes. The registry has collected data of 8428 pregnant and postpartum women with COVID-19 from 19 participating centers across Maharashtra in a near real-time manner. The registry first reported that the delta variant (B.1.617.2) dominant second wave was more lethal (case fatality rate 5.7%) to pregnant and postpartum women than the alpha (0.7%) dominant wave of COVID-19 in India. There was also a higher incidence of moderate to severe cases, intensive care admissions and maternal complications including pre-eclampsia, low birth weight and preterm deliveries during the delta wave. The omicron dominant third wave of the COVID-19 pandemic exhibited a higher transmission rate compared to the previous two waves, causing a surge in cases but minimally impacting adverse outcomes. The registry further analyzed and reported the impact of COVID-19 on pregnant and postpartum women with comorbidities, coinfections, twin pregnancies, and neonatal outcomes, while providing crucial policy inputs to improve maternal and newborn health during the pandemic. The registry model can be replicated at tertiary care hospitals across India to understand various maternal-neonatal outcomes. The evidence generated from PregCovid registry was useful for improved clinical management and also contributed to a policy decision on COVID-19 vaccination in pregnant women in India. The registry envisions a collaboration with similar regional, national and international registries to form an international consortium for data sharing and reporting to promote global policy level interventions and advocates a sustainable and collective response to improve the COVID-19 global vaccination coverage.

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SARS-CoV-2-related polyradiculitis during pregnancy

Finsterer,

Mehri

2024

Indian Journal of Anaesthesia

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Neurological complications of COVID-19 and spontaneous abortion in a pregnant woman – A case report

Cited by 5 publications

References 6 publications

Pregnancy and neurologic complications of COVID‐19: A scoping review

Pregnancy and neurologic complications of COVID‐19: A scoping review

Impact of COVID-19 pandemic on maternal and neonatal outcomes: A narrative review and evidence from the PregCovid registry

SARS-CoV-2-related polyradiculitis during pregnancy

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