Guillain-Barré syndrome associated with SARS-CoV-2 infection. Comments after 16 published cases

Guijarro-Castro, Cristina; Rosón-González, M; Abreu, Angélica Kely de; García-Arratibel, A.; Ochoa-Mulas, M.

doi:10.1016/j.nrleng.2020.06.002

Cited by 10 publications

(5 citation statements)

References 13 publications

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“…31 Preceding SARS-CoV-2 infection has also been associated with GBS. 32 Spine MRI is generally normal; when abnormal, GBS/AIDP may present as slightly prominent nerve roots on non-contrast sequences and with avid, ventral predominant enhancement of the conus medullaris and cauda equina nerve roots on post-contrast sequences (Figure 4) 33. Chronic inflammatory demyelinating polyneuropathy. CIDP is an acquired demyelinating disease involving the peripheral nerves and is seen as a chronic counterpart to AIDP.…”

Section: Methodsmentioning

confidence: 99%

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Autoimmune diseases of the spine and spinal cord

et al. 2023

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Magnetic resonance imaging (MRI) and clinicopathological tools have led to the identification of a wide spectrum of autoimmune entities that involve the spine. A clearer understanding of the unique imaging features of these disorders, along with their clinical presentations, will prove invaluable to clinicians and potentially limit the need for more invasive procedures such as tissue biopsies. Here, we review various autoimmune diseases affecting the spine and highlight salient imaging features that distinguish them radiologically from other disease entities.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Autoimmune diseases of the spine and spinal cord

et al. 2023

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“…[24][25][26][27] Neurologic presentations preceded the respiratory symptoms in 2 patients (2.5%). 22,23 Clinical GBS variants, including MFS and polyneuritis cranialis were evident in 9 (11.5%) 14,20,[28][29][30][31][32][33] and 2 patients (1.2%), 29,34 respectively.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

COVID-19 infection complicated by Guillain-Barre Syndrome: a systematic review of clinical features, pathogenic mechanism, and respiratory failure

et al. 2021

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Background: The World Health Organization (WHO) declared a pandemic in March 2020 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given the neurotropism feature of the coronavirus and growing number of COVID-19 associated neurological disorders, including Guillain Barre syndrome (GBS), we conducted a systematic review to thoroughly describe the clinical features, diagnostic workup, and clinical outcome of COVID-19 associated GBS in 78 cases. Methods: We identified case reports and case series of COVID-19 associated GBS by conducting a search in the PubMed/MEDLINE and EMBASE databases. We assessed the quality of studies using an appraisal checklist presented by Cochrane Murad et al. Extracted data included demographic characteristics, clinical presentation, diagnostic workup, and outcome. Results: The systematic search yielded a total of 60 articles reporting 78 patients with a diagnosis of COVID-19 associated GBS. The patients were mainly male (65.3%) with an average age of 57 years. The ascending symmetrical paresis was the most common presentation (79.4%), with demyelinating pattern in 54 patients (79.4%). The CSF analysis showed albuminocytologic dissociation in 48 patients (75%). The mortality of COVID-19 associated GBS was estimated as 6.4% attributable to progressive respiratory failure. Conclusion: Given the associated morbidities such as respiratory failure in patients with COVID-19 associated GBS, its timely detection is crucial to prevent poor clinical outcomes. On the other hand, clinicians must be vigilant to identify the clinical findings of SARS-CoV-2 infection in newly diagnosed GBS patients, as this might be a neurological complication of the subclinical viral infection.

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“…Prolonged persistence of brainstem dysfunction following COVID-19 may contribute to the long COVID-19 syndrome [46]. Furthermore, COVID-19 has been linked to disorders such as stroke, demyelinating diseases, and Guillain-Barre Syndrome that will require rehabilitation programs in their follow-up [47,48].…”

Section: Neurologic Systemmentioning

confidence: 99%

The Role of Physical Medicine and Rehabilitation in Long Covid-19 Management

Koçyiğit¹

2022

AAEE

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COVID-19 is an infectious disease that can have a multi-system involvement, most notably, the respiratory tract. After acute infection, a considerable proportion of patients suffer from persistent symptoms and signs, defined as long COVID-19. Depending on the affected systems and organs, patients can experience various clinic pictures. Rehabilitation approaches serve a crucial role in providing functional recovery and improving quality of life for COVID-19 survivors. As a result of the wideness of the clinical spectrum of the long COVID-19, rehabilitation practices differ according to the affected systems. Therefore, the formation of multidisciplinary rehabilitation teams is an inevitable necessity. The establishment of specific centers for long COVID-19 rehabilitation will be beneficial. If it is not possible, existing rehabilitation centers should be strengthened for this purpose. Since the pulmonary system and respiratory tract are the most affected structures, one of the main issues to be considered in long COVID-19 cases is cardiopulmonary rehabilitation. Patients experience musculoskeletal disorders such as atrophy, sarcopenia, poor physical performance and contracture due to long-term hospitalization, intensive care treatment, quarantine practices and immobilization. Rehabilitation practices also focus on these disorders. All rehabilitation practices in long COVID-19 patients should start with low intensity, and parameters such as intensity and frequency should be increased as the patient's tolerance improves. In high-risk cases, parameters including oxygen saturation, blood pressure, and heart rhythm should be monitored. Health-care authorities should prioritize the rehabilitation of the long COVID-19 syndrome and invest in this area. Authorities, physicians and patients should collaborate to facilitate long COVID-19 rehabilitation and to establish a self-contained system.

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Guillain-Barré syndrome associated with SARS-CoV-2 infection. Comments after 16 published cases

Cited by 10 publications

References 13 publications

Autoimmune diseases of the spine and spinal cord

Autoimmune diseases of the spine and spinal cord

COVID-19 infection complicated by Guillain-Barre Syndrome: a systematic review of clinical features, pathogenic mechanism, and respiratory failure

The Role of Physical Medicine and Rehabilitation in Long Covid-19 Management

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