Guillain‐Barré syndrome as the presenting manifestation of hepatitis C infection

Klippel, Nina De; Hautekeete, M. L.; Keyser, Jacques De; Ebinger, Guy

doi:10.1212/wnl.43.10.2143

Cited by 26 publications

(21 citation statements)

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“…Although a causal relationship between hepatitis C and Guillain-Barre syndrome could not be completely ascertained in these two patients, because the prevalence of both diseases allows theoretically for a fortuitous association, the first patient is very similar to other reported cases (6)(7)(8)(9)(10). In the second patient, hepatitis C could be a trigger of autoimmune manifestations in an individual prone to autoimmunity.…”

Section: Discussionsupporting

confidence: 57%

“…The causative viruses were the hepatitis A (9) or B (6,7,9) viruses, cytomegalovirus (3), Epstein-Barr virus (8), or unknown viruses, called "non-A, non-B" before the advent of serological testing for hepatitis C (3,8,9). Hepatitis C has already been linked in one patient to the appearance of GBS (10). It is also noteworthy that in one series where blood testing was not performed, 10% of cases of GBS were "surgery-related", at a time when transmission of infective agents, especially those of B and non-A, non-B hepatitides, was common in hospitals (1 1).…”

Section: Discussionmentioning

confidence: 99%

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Hepatitis C associated with Guillain‐Barré syndrome

Lacaille

Zylberberg

Hagège

et al. 1998

Liver

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Hepatitis C is frequently associated with immune-mediated diseases, such as cryoglobulinemia. Guillain-Barre syndrome is an acute demyelinating neuropathy of probable immune pathogenesis. We describe two patients with Guillain-Barre syndrome, and associated chronic hepatitis C, the second one previously treated with interferon. The link between both conditions may be hepatitis C being the trigger of this immune polyneuropathy. Guillain-Barre syndrome should be added to the list of conditions associated with hepatitis C. Case reports Patient 1A 5 1-year-old man was first seen for paresthesias and rapidly progressive weakness of all four limbs. He had probably received a blood transfusion 15 years earlier following a car injury. Neurological examination disclosed paresis of four limbs, and areflexia. Blood tests showed abnormal liver enzymes (ALT 375 IU, AST 225 IU, GGT 175 IU). Cerebrospinal fluid was normal. Anti-HCV antibodies were positive on ELISA and RIBA (second generation assays). No auto-antibodies were found. Electromyography showed an asymmetrical axono-myelinic polyradiculoneuritis suggestive of Guillain-Barre syndrome. Paralysis of respiratory

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Hepatitis C associated with Guillain‐Barré syndrome

Lacaille

Zylberberg

Hagège

et al. 1998

Liver

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“…Guillain-Barre syndrome has been reported in association with hepatitis A [6], hepatitis B [7], hepatitis C [8], and hepatitis D [9] infections. Neurological sequelae of hepatitis E infection are rare but have been reported to include oculomotor nerve palsy [10], meningoencephalitis [11], transverse myelitis [12], and neuralgic amyotrophy [13], in addition to Guillain-Barre syndrome [2][3][4][5].…”

Section: Discussionmentioning

confidence: 99%

Anti-glycolipid GM2-positive Guillain–Barre syndrome due to hepatitis E infection

et al. 2010

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“…There was one report describing this un usual association [54], A 35-year-old woman with no risk factor for viral hepatitis was admitted with typical Guillain-Barre syn drome. At the time of admission she was found to have raised aminotransferase levels and a positive anti-HCV antibody.…”

Section: Guillain-barre Syndrom Ementioning

confidence: 99%

Extrahepatic Manifestations of Hepatitis C

Gordon¹

1996

Dig Dis

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Shortly after the discovery of the hepatitis C virus, it was realized that this infectious agent caused more than just liver disease. A remarkable array of extrahepatic manifestations of hepatitis C has now been described. Many of these associated syndromes implicate the hepatitis C virus as a mediator of autoimmunity or of immune complex formation. These disorders include mixed essential cryoglobulinemia, autoimmune hepatitis, glomerulonephritis, thyroiditis, and possibly Sjö-gren’s syndrome. The hepatitis C virus has also been strongly linked to two skin disorders: prophyria cutanea tarda and lichen planus. Other possible hepatitis-C-associated diseases described in the literature include idiopathic pulmonary fibrosis, IgA deficiency, Mooren’s corneal ulcers, Behçet’s syndrome, polyarthritis, Guillain-Barré syndrome, idiopathic thrombocytopenic purpura, and others. A number of these reported diseases have either responded to or been cured by a therapeutic course of alpha interferon. This report discusses the reported extrahepatic manifestations of hepatitis C as of mid-1995.

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Guillain‐Barré syndrome as the presenting manifestation of hepatitis C infection

Cited by 26 publications

References 0 publications

Hepatitis C associated with Guillain‐Barré syndrome

Hepatitis C associated with Guillain‐Barré syndrome

Anti-glycolipid GM2-positive Guillain–Barre syndrome due to hepatitis E infection

Extrahepatic Manifestations of Hepatitis C

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