Guillain−Barré syndrome and hyponatraemia

Colls, B. M.

doi:10.1046/j.1445-5994.2002.00322.x

Cited by 33 publications

(21 citation statements)

References 9 publications

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“…[1][2][3][4][5] However, the diagnosis of IVIG-induced pseudohyponatremia in these previous reports was based on measurements of plasma [Na + ] using an ion-selective electrode (ISE) in diluted plasma specimens (indirect ISE). 1,2,4,5 In this M.K. Nguyen (*) · A. Rastogi · I. Kurtz Division of Nephrology, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Room 7-155 Factor Building, Los Angeles, CA 90095, USA Tel.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5] Because IVIG therapy results in an increase in the nonaqueous phase of plasma, IVIG is thought to cause pseudohyponatremia, rather than true hyponatremia. [1][2][3][4][5] However, the diagnosis of IVIG-induced pseudohyponatremia in these previous reports was based on measurements of plasma [Na + ] using an ion-selective electrode (ISE) in diluted plasma specimens (indirect ISE). 1,2,4,5 In this M.K.…”

Section: Introductionmentioning

confidence: 99%

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True hyponatremia secondary to intravenous immunoglobulin

2006

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Hyponatremia is characterized as either "true hyponatremia," which represents a decrease in the Na(+) concentration in the water phase of plasma, or "pseudohyponatremia," which is due to an increased percentage of protein or lipid in plasma, with a normal plasma water Na(+) concentration ([Na(+)]). Pseudohyponatremia is a known complication of intravenous immunoglobulin (IVIG). Because IVIG has been reported to result in post-infusional hyperproteinemia, IVIG-induced hyponatremia has been attributed to pseudohyponatremia. In this case report, we demonstrate that IVIG therapy can result in true hyponatremia, resulting from sucrose-induced translocation of water from the intracellular compartment (ICF) to the extracellular compartment (ECF), as well as the infusion of a large volume of dilute fluid, in patients with an underlying defect in urinary free water excretion.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

True hyponatremia secondary to intravenous immunoglobulin

2006

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“…Beim GBS ist eine Erniedrigung des Serumnatriums in bis zu 30% der Fälle beschrieben [2]. Mögliche Ursachen hierfür sind einerseits eine Pseudohyponatriämie im Rahmen einer IVIG-Therapie [8] und andererseits ein SIADH [7].…”

Section: Hyponatriämie Beim Gbsunclassified

Guillain-Barré-Syndrom und Syndrom der inadäquaten Adiuretinsekretion

et al. 2006

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Several neurologic disorders including Guillain-Barré syndrome (GBS) are associated with hyponatremia. Hyponatremia and its overly fast correction have major implications to the course of the underlying neurologic disease. We report a case of GBS complicated by hyponatremia secondary to the development of inadequate antidiuretic hormone secretion syndrome. Differential diagnosis, pathophysiology, and therapeutic approach of hyponatremia in association with GBS are discussed.

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“…An altered osmoreceptor response has been proposed as a possible cause of SIADH in GBS [3]. Likewise, in our CANOMAD patient a dysregulation of osmolarity receptors might be consequent to binding of some anti-disialosyl antibodies to specific hypothalamic epitopes.…”

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confidence: 92%

“…Moreover, SIADH has been reported in association with several immune-mediated neuropathies, including Guillain Barrè (GBS) [2,3] and Miller-Fisher syndrome [4].…”

mentioning

confidence: 99%