SIADH in a patient with sensory ataxic neuropathy with anti-disialosyl antibodies (CANOMAD)

A Case of Miller-Fisher Syndrome with Syndrome of Inappropriate Secretion of Antidiuretic Hormone

“…Anti-GD2 monoclonal antibody reacted with the myelin sheaths in the peripheral nerves as well as with the pituicyte cytoplasm in the posterior lobe of the pituitary gland [10,11]. Iorio et al [12] reported a patient who developed SIADH during the first relapse chronic ataxic neuropathy with ophthalmoplegia, IgM paraprotein, cold agglutinins, and disialosyl antibodies. The dysregulation of osmolarity receptors may be consequent to binding of some anti-disialosyl antibodies to specific hypothalamic epitopes [12].…”

“…Iorio et al [12] reported a patient who developed SIADH during the first relapse chronic ataxic neuropathy with ophthalmoplegia, IgM paraprotein, cold agglutinins, and disialosyl antibodies. The dysregulation of osmolarity receptors may be consequent to binding of some anti-disialosyl antibodies to specific hypothalamic epitopes [12]. The elevation of anti-GD1b, -GQ1b, and -GT1a antibodies may be pathologically related to SIADH.…”

Légzési elégtelenséggel járó CANOMAD szindróma

“…Earlier described CANOMAD cases reported patients with optic nerve involvement, extramembranous glomerulonephritis, and a syndrome of inappropriate antidiuretic hormone secretion (SIADH) 2,[11][12][13][14] . Cases without ophthalmoplegia, fur thermore, with temporary respiratory failure associated with facial involuntary movements were also mentioned 2,[11][12][13][14] . We report a case of CANO -MAD syndrome with severe respiratory failure followed by neuropathological evaluation.…”

Canomad: report of a case with a 40‐year history and autopsy. Is this a sensory ganglionopathy with neuromuscular junction blockade?

“…The diagnosis of Waldenstrom macroglobulinemia only requires demonstration of a serum IgM monoclonal pararotein with histological evidence of bone marrow infiltration by lymphoplasmacytic cells, without a minimal serum IgM level or minimal percentage of bone marrow infiltration . However, bone marrow examination was not reported or performed in patients from the largest clinical series of 18 cases or in case reports of a further 6 patients Three patients reported with CANOMAD had a negative bone marrow, and 1 autopsy showed 10–15% plasma cells in the bone marrow with no comment regarding light chain restriction or IgH clonality studies . Our patient underwent bone marrow examination due to the elevated serum IgM (15 g/L), mild anemia, and associated neuropathy.…”