Guillain-Barré syndrome and arboviral infection in Brazil

Neurological complications associated with emerging viruses in Brazil

“…These results support previous findings indicating an association between arboviruses and neuropathies in Brazil during the Zika virus epidemic . The rates of rash, facial paralysis, and paraparesis in patients with GBS in Metropolitan Area II are similar to those previously reported for GBS cases in Latin America and the Caribbean .…”

Carpal tunnel syndrome observed after an arbovirus infection: A preliminary case series report

“…Outbreaks of arbovirus infection have been described in several countries in the Americas, especially in Brazil, since 2013 [ [2] , [3] , [4] ]. Dengue, Zika and chikungunya are diseases caused by arboviruses transmitted by the same vector, the mosquito Aedes aegypti.…”

“…Dengue, Zika and chikungunya are diseases caused by arboviruses transmitted by the same vector, the mosquito Aedes aegypti. In Brazil, outbreaks of dengue have been reported for more than two decades [ 3 ], and since 2015 cases of Zika virus have been reported in Natal, in north-eastern Brazil [ 3 , 4 ], and cases of chikungunya have been reported in several countries in South America, including Brazil. Although the clinical picture is very similar between these three diseases, chikungunya and Zika virus have demonstrated potential neurological impairment associated with the general clinical picture of fever, cutaneous rash, myalgia, headache and arthralgia [ 2 , 5 ].…”

“…In cases of chikungunya, persistent and lasting arthralgia has been reported [ 5 , 6 ]. Some authors have reported extensive involvement of the nervous system during infection by these agents [ 3 , 4 ]. Guillain-Barre syndrome (GBS), myelitis, facial paresis and encephalitis have been reported in some patients with arboviruses [ 3 , 4 ].…”

Mapping innate and adaptive immune function in arbovirus infections

“…A key part of this effort has been in defining immune correlates of susceptibility to arboviruses. In parts of the globe such as Brazil, Aedes egypti mosquitoes may variably harbour combinations of Dengue serotypes 1–4, Chikungunya and Zika viruses . These infections share a partially overlapping set of symptoms including rash, fever, fatigue and headache, yet there are also differences in the most severe disease manifestations, such as the association of Dengue with haemorrhagic fever, of Chikungunya with arthritis, and of Zika with microcephaly and other neurological manifestations.…”