Guillain-Barr� syndrome during treatment with ofloxacin

Schmidt, Steven M.; Cordt-Schlegel, A; Heitmann, R.N.

doi:10.1007/bf00874121

Cited by 6 publications

(2 citation statements)

References 8 publications

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“…The occurrence of peripheral neuropathy has already been reported with FQs [ 2 , 3 , 4 , 5 ]. Small-fiber neuropathy has been described as an adverse effect of ciprofloxacin [ 10 ] as well as Guillain-Barré syndrome (GBS) during treatment with ofloxacin [ 11 ]. In this study, we reported a case of severe FQ-induced peripheral neuropathy with long-term recovery.…”

Section: Discussionmentioning

confidence: 99%

Severe Acute Axonal Neuropathy Induced by Ciprofloxacin: A Case Report

Popescu¹

2018

Case Rep Neurol

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Fluoroquinolones increase the risk of peripheral neuropathy. The present work aims to report a case of fluoroquinolone-related severe axonal neuropathy. The subject of this study was a 62-year-old man who exhibited generalized sensory disturbances 4 days after treatment by ciprofloxacin prescribed for urinary infection. Electrodiagnostic studies revealed severe motor-sensory axonal neuropathy with widespread fibrillation potentials in support of generalized motor polyradiculopathy. There was no evidence of conduction blocks or albuminocytologic dissociation in favor of an autoimmune inflammatory reaction. The only pathological biomarker was the reduction of serum folate. According to this case, we suggest that folate level could be routinely measured and supplementation should be performed in patients with fluoroquinolone-induced neuropathy.

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Section: Discussionmentioning

confidence: 99%

Severe Acute Axonal Neuropathy Induced by Ciprofloxacin: A Case Report

Popescu¹

2018

Case Rep Neurol

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“…This patient also had history of breast cancer, kidney dysfunction, systemic lupus erythematosis, and was treated with other medications such as chloroquine and NSAIDs. Schmidt et al [6] report a patient with electro physiologically confirmed Guillain-Barre syndrome three days after starting ofloxacin, and relate the condition to treatment with this medication.…”

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confidence: 99%

Do Fluoroquinolones Cause Neuropathy?

Ghavanini¹

2017

OAJNN

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Fluoroquinolone antibiotics are thought to be associated with peripheral neuropathy. Since 2004, the United States Food and Drug Administration (FDA) requires the manufacturers of systemic fluoroquinolone drugs to list peripheral neuropathy on the label for these drugs [1]. It further recommends that patients with symptoms of peripheral neuropathy after taking systemic fluoroquinolone to stop the medication and to be treated with an alternative non-fluoroquinolone antibacterial drug. This decision is based on FDA's review of the Adverse Event Reporting System (AERS) database. This data has been reviewed and published. The data shows that out of 46,257 adverse event reports submitted for fluoroquinolones, 539 reports involved peripheral neuropathy. Of these reported cases, 119 had at least one concomitant risk factor for peripheral neuropathy and 48 had Guillain-Barre syndrome.

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Drug-Induced Guillain-Barré Syndrome

Jain

2021

Drug-Induced Neurological Disorders

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Guillain-Barr� syndrome during treatment with ofloxacin

Cited by 6 publications

References 8 publications

Severe Acute Axonal Neuropathy Induced by Ciprofloxacin: A Case Report

Severe Acute Axonal Neuropathy Induced by Ciprofloxacin: A Case Report

Do Fluoroquinolones Cause Neuropathy?

Drug-Induced Guillain-Barré Syndrome

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