Severe Acute Axonal Neuropathy Induced by Ciprofloxacin: A Case Report

Abstract

Fluoroquinolones increase the risk of peripheral neuropathy. The present work aims to report a case of fluoroquinolone-related severe axonal neuropathy. The subject of this study was a 62-year-old man who exhibited generalized sensory disturbances 4 days after treatment by ciprofloxacin prescribed for urinary infection. Electrodiagnostic studies revealed severe motor-sensory axonal neuropathy with widespread fibrillation potentials in support of generalized motor polyradiculopathy. There was no evidence of conduction blocks or albuminocytologic dissociation in favor of an autoimmune inflammatory reaction. The only pathological biomarker was the reduction of serum folate. According to this case, we suggest that folate level could be routinely measured and supplementation should be performed in patients with fluoroquinolone-induced neuropathy.

Quinolones-Induced Musculoskeletal, Neurological, and Psychiatric ADRs: A Pharmacovigilance Study Based on Data From the Italian Spontaneous Reporting System

“…Similarly, musculoskeletal ADRs are usually represented by localized pain, swelling, tenderness, erythema, or itchiness over tendon sites (Van Der Linden et al, 2001;Khaliq and Zhanel, 2003). The median time to event that we have found is in line with the latency period reported by other studies (from few hours to few weeks) (Popescu, 2018;Van Der Linden et al, 2001;Ng and Naughton, 2007;Akali and Niranjan, 2008;Golomb et al, 2015) as well as with the suggested mechanism and factors underlying the occurrence of ADRs that we have evaluated (Akahane et al, 1989;Schwartz and Calvert, 1990;Lipsky and Baker, 1999;Kushner et al, 2001;Tomé and Filipe, 2011;Rubio-Nazabal et al, 2013).…”

Acute Motor Axonal Neuropathy Improvement 20 Days After Hyperbaric Oxygen Therapy

“…Complete recovery was only achieved after five years. 10 Propionate is another treatment which was given in the case of a 33-year-old man after receiving IVIG. The regression of this patient’s symptoms and improvement in an additional examination appeared to be very good.…”

Fluoroquinolone antibiotics: safety of use by the example of ciprofloxacin

“…В литературе имеются свидетельства появления долгосрочных неблагоприятных эффектов со стороны периферической нервной системы (ПНС) при использовании фторхинолонов [13]. Предполагаемая частота нейропатии у пациентов, получавших ципрофлоксацин, составляет один случай на 17 000 пациентов [25], то есть такая НР возникает очень редко. В отечественной базе данных спонтанных сообщений зафиксировано всего 8 случаев появления парестезии и дизестезии и один случай нейропатии.…”