Guidestar-assisted wavefront-shaping methods for focusing light into biological tissue

Horstmeyer, Roarke; Ruan, Haowen; Yang, Changhuei

doi:10.1038/nphoton.2015.140

Cited by 524 publications

(366 citation statements)

References 116 publications

Supporting

Mentioning

364

Contrasting

Unclassified

Order By: Relevance

“…Several guidestar recipes have been proposed utilizing the photo-acoustic effect, two-photon absorption, and particle displacements, as summarized in a previous review. 28 The details regarding the current state-of-the-art photo-acoustic guidestar technologies will be further discussed in Sec. III.…”

Section: Focusing Through Biological Tissuesmentioning

confidence: 99%

Perspective: Wavefront shaping techniques for controlling multiple light scattering in biological tissues: Toward in vivo applications

Park

Lee

et al. 2018

APL Photonics

View full text Add to dashboard Cite

Multiple light scattering has been regarded as a barrier in imaging through complex media such as biological tissues. Owing to recent advances in wavefront shaping techniques, optical imaging through intact biological tissues without invasive procedures can now be used for direct experimental studies, presenting promising application opportunities in in vivo imaging and diagnosis. Although most of the recent proof of principle breakthroughs have been achieved in the laboratory setting with specialties in physics and engineering, we anticipate that these technologies can be translated to biological laboratories and clinical settings, which will revolutionize how we diagnose and treat a disease. To provide insight into the physical principle that enables the control of multiple light scattering in biological tissues and how recently developed techniques can improve bioimaging through thick tissues, we summarize recent progress on wavefront shaping techniques for controlling multiple light scattering in biological tissues.

show abstract

Section: Focusing Through Biological Tissuesmentioning

confidence: 99%

Perspective: Wavefront shaping techniques for controlling multiple light scattering in biological tissues: Toward in vivo applications

Park

Lee

et al. 2018

APL Photonics

View full text Add to dashboard Cite

show abstract

“…Therefore, the choosing of a wavefront modulator is usually a trade-off between the speed, the modulation efficiency, the pixel number, and the cost, among many other requirements from the specific application. Since the initial implementation, wavefront shaping has seen many exciting advancements and has been explored for wide applications, which has been well reviewed [19,[79][80][81] and, thus, will not be reiterated herein. However, it must be pointed out that most efforts in the community have centered on three aspects: to improve the focal intensity enhancement ratio (R), to shorten the optimization process, and to seek appropriate noninvasive guide star to produce the feedback signal.…”

Section: Wavefront Shapingmentioning

confidence: 99%

Wavefront Shaping and Its Application to Enhance Photoacoustic Imaging

Lai

2017

Applied Sciences

View full text Add to dashboard Cite

Abstract:Since its introduction to the field in mid-1990s, photoacoustic imaging has become a fast-developing biomedical imaging modality with many promising potentials. By converting absorbed diffused light energy into not-so-diffused ultrasonic waves, the reconstruction of the ultrasonic waves from the targeted area in photoacoustic imaging leads to a high-contrast sensing of optical absorption with ultrasonic resolution in deep tissue, overcoming the optical diffusion limit from the signal detection perspective. The generation of photoacoustic signals, however, is still throttled by the attenuation of photon flux due to the strong diffusion effect of light in tissue. Recently, optical wavefront shaping has demonstrated that multiply scattered light could be manipulated so as to refocus inside a complex medium, opening up new hope to tackle the fundamental limitation. In this paper, the principle and recent development of photoacoustic imaging and optical wavefront shaping are briefly introduced. Then we describe how photoacoustic signals can be used as a guide star for in-tissue optical focusing, and how such focusing can be exploited for further enhancing photoacoustic imaging in terms of sensitivity and penetration depth. Finally, the existing challenges and further directions towards in vivo applications are discussed.

show abstract

“…In this way, an optimum wavefront can be obtained to maximize the light intensity at the target location to form an optical focus. Optical phase conjugation methods achieve light focusing by phase conjugating the scattering light field emitted from a guidestar [19] located at the target location. Traditionally, transmission matrix methods first measure the scattered light fields corresponding to different incident light fields (i.e.…”

Section: Introductionmentioning

confidence: 99%

Focusing light through scattering media by transmission matrix inversion

Xu¹,

Ruan²,

Liu³

et al. 2017

Opt. Express

Self Cite

View full text Add to dashboard Cite

Focusing light through scattering media has broad applications in optical imaging, manipulation and therapy. The contrast of the focus can be quantified by peak-to-background intensity ratio (PBR). Here, we theoretically and numerically show that by using a transmission matrix inversion method to achieve focusing, within a limited field of view and under a low noise condition in transmission matrix measurements, the PBR of the focus can be higher than that achieved by conventional methods such as optical phase conjugation or feedback-based wavefront shaping. Experimentally, using a phase-modulation spatial light modulator, we increase the PBR by 66% over that achieved by conventional methods based on phase conjugation. In addition, we demonstrate that, within a limited field of view and under a low noise condition in transmission matrix measurements, our matrix inversion method enables light focusing to multiple foci with greater fidelity than those of conventional methods.

show abstract

Guidestar-assisted wavefront-shaping methods for focusing light into biological tissue

Cited by 524 publications

References 116 publications

Perspective: Wavefront shaping techniques for controlling multiple light scattering in biological tissues: Toward in vivo applications

Perspective: Wavefront shaping techniques for controlling multiple light scattering in biological tissues: Toward in vivo applications

Wavefront Shaping and Its Application to Enhance Photoacoustic Imaging

Focusing light through scattering media by transmission matrix inversion

Contact Info

Product

Resources

About