Guidelines of the Paul-Ehrlich-Society of Chemotherapy, the German Respiratory Diseases Society, the German Infectious Diseases Society and of the Competence Network CAPNETZ for the Management of Lower Respiratory Tract Infections and Community-acquired Pneumonia

Höffken, G.; Lorenz, Joachim; Kern, Winfried V.; Welte, Tobias; Bauer, Tobias; Dalhoff, K; Dietrich, Eva Susanne; Ewig, Santiago; Gastmeier, Petra; Grabein, B.; Halle, E.; Kolditz, Martin; Marre, R.; Sitter, H.

doi:10.1055/s-0029-1243910

Cited by 50 publications

(27 citation statements)

References 9 publications

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“…Secondly, we found that younger patients more frequently received quinolones. This practice is not in line with European and German guidelines [24,25]. The reasons behind this attitude are unclear.…”

Section: Discussionmentioning

confidence: 89%

Community-acquired pneumonia in younger patients is an entity on its own

Klapdor

Ewig²,

Pletz³

et al. 2011

Eur Respir J

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Community-acquired pneumonia (CAP) is now most frequent in elderly patients. CAP in the younger patient has attracted much less attention. Therefore, we compared patients with CAP aged 18 to ,65 yrs with those aged o65 yrs.Data from the prospective multicentre Competence Network for Community Acquired Pneumonia Study Group (CAPNETZ) database were analysed for potential differences in baseline characteristics, comorbidities, clinical presentation, microbial investigations, aetiologies, antimicrobial treatment and outcomes.Overall, 7,803 patients were studied. The proportion of younger patients (aged ,65 yrs) was 52.3% (18 to ,30 yrs 6.4%; ,40 yrs 17.1%; ,50 yrs 29.4%). Comorbidity was present in only half of the younger patients (46.6% versus 88.2%). Fever and chest pain were more common. Most younger patients presented with mild CAP (74.0% had a CURB-65 score of 0 (confusion of new onset, urea .7 mmol?L -1 , respiratory rate of o30 breaths?min -1 , blood pressure ,90 mmHg or diastolic blood pressure f60 mmHg, age o65 yrs)). Overall, Streptococcus pneumoniae and Mycoplasma pneumoniae were the most frequent pathogens in the younger patients. Short-term mortality was very low (1.7% versus 8.2%) and even lower in patients without comorbidity (0.3% versus 2.4%). Longterm mortality was 3.2% versus 15.9%, also lower in patients without comorbidity (0.8% versus 6.1%).Most of the differences found clearly arise after the fifth or within the middle of the sixth decade. CAP in the younger patient is a clinically distinct entity.

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Section: Discussionmentioning

confidence: 89%

Community-acquired pneumonia in younger patients is an entity on its own

Klapdor

Ewig²,

Pletz³

et al. 2011

Eur Respir J

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“…In case 4, it is questionable if the Unyvero™-detected Chlamydia result was of any clinical significance, as pathogen detection was below the Unyvero™ Chlamydia threshold and sepsis was confirmed by autopsy. Moreover, a potential pneumonia caused by anaerobic germs or by the relative frequent CAP-causing fastidious pathogen Mycoplasma pneumonia [17] was not detected by the molecular prototype device, as these pathogens were not included in the panel.…”

Section: Discussionmentioning

confidence: 99%

“…This study intended to compare the established standard-of-care for pathogen and antibiotic resistance detection to the Unyvero™ prototype pneumonia application. It also intended to aid in the diagnosis of pneumonia by identifying genes of 17 [16] . Test results were compared to findings of conventional culture and AST.…”

Section: Methodsmentioning

confidence: 99%

Molecular detection evaluation of pneumonia-associated fastidious pathogens and comparison to conventional microbiological results

Karrasch

Rödel

Keller

et al. 2015

CRCP

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“…Der Nachweis einer Legionellenpneumonie gilt als gesichert, wenn mindestens eines der folgenden Kriterien erfüllt wurde [12,13] …”

Section: Mikrobiologische Diagnostikunclassified

Ambulant erworbene Legionellenpneumonie

Baum

Lück²

2011

Bundesgesundheitsbl.

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Legionella are present in the environment as well as in biofilms of water installation systems. Most Legionella live in amoebae. More than 51 different species of Legionella have been identified; however, most pneumonias are caused by Legionella pneumophila serogroup 1. Legionnaire's disease has an incidence of about 4% in Germany. Most cases of Legionnaire's disease are sporadic. Microbiological identification of Legionella can be achieved by cultivation of Legionella spp. on specific media, performing of Legionella-specific PCR from respiratory samples, or Legionella urinary antigen testing. Patients with severe underlying diseases, patients receiving immunosuppression, and patients who are heavy smokers have a predisposition to Legionnaire's disease. Men are significantly more often affected. Whereas outpatients show a mild clinical course, mortality for hospitalized patients is 11.2%. It can be assumed that only a minority of cases of Legionnaire's disease is recognized and reported in Germany.

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Guidelines of the Paul-Ehrlich-Society of Chemotherapy, the German Respiratory Diseases Society, the German Infectious Diseases Society and of the Competence Network CAPNETZ for the Management of Lower Respiratory Tract Infections and Community-acquired Pneumonia

Cited by 50 publications

References 9 publications

Community-acquired pneumonia in younger patients is an entity on its own

Community-acquired pneumonia in younger patients is an entity on its own

Molecular detection evaluation of pneumonia-associated fastidious pathogens and comparison to conventional microbiological results

Ambulant erworbene Legionellenpneumonie

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