Guidelines in the management of CNS tumors

Redjal, Navid; Venteicher, Andrew S.; Dang, Danielle; Sloan, Andrew E.; Kessler, Remi A.; Baron, Rebecca B; Hadjipanayis, Constantinos; Chen, Clark C.; Ziu, Mateo; Olson, Jeffrey J.; Nahed, Brian V.

doi:10.1007/s11060-020-03530-8

Cited by 12 publications

(5 citation statements)

References 192 publications

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“…Additionally, due to its lower incidence rate compared to other tumors, the advanced treatments of CNS tumors are more likely emerge in developed countries and major cities. The current treatments of CNS tumors is still dominated by surgical resection, and the efficacy of chemotherapy and radiotherapy timing, the specific doses, and other new treatments, such as electric field therapy, are still unclear [ 25 ]. Therefore, more studies are needed to identify other suitable treatments to reduce the disease burden.…”

Section: Discussionmentioning

confidence: 99%

Analysis and prediction of central nervous system tumor burden in China during 1990–2030

Qi,

Yu,

Chen

et al. 2024

PLoS ONE

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Central nervous system (CNS) tumors, due to their unique locations, pose a serious threat to human health and present challenges to modern medicine. These tumors exhibit notable epidemiological characteristics across various ethnicities, regions, and age groups. This study investigated the trend of disease burden of CNS tumors in China from 1990–2019 and predicted the incidence and death rate from 2020–2030. Employing data from the 2019 Global Burden of Disease (GBD) database, we utilized key indicators to scrutinize the disease burden associated with CNS tumors in China. The analysis employed the Joinpoint model to track the trend in disease burden, calculating both the annual percentage change (APC) and average annual percentage change (AAPC). Additionally, the Matlab software facilitated the creation of a gray model to forecast the incidence and death rate of CNS tumors in China spanning from 2020 to 2030." In 2019, the age-standardized incidence rate, prevalence rate, death rate, and disability-adjusted life years (DALYs) associated with CNS tumors in China were among the high level in the world. The standardized prevalence rate and DALYs of CNS tumors in China residents showed a stable fluctuation trend with age; however, age-standardized death and incidence rate demonstrated a generally upward trend with age. In China, the age-standardized prevalence and incidence rate of males were lower than those for female residents, while the age-standardized death rate and DALYs among males surpassed those of females. From 1990–2019, the age-standardized prevalence and incidence rate of CNS tumors in China exhibited an increasing trend. The age-standardized death rate and DALYs showed a contrasting trend. According to the gray model’s prediction, incidence rate of CNS tumors would continue rising while the death rate is expected to decline in China from 2020–2023. The burden of CNS tumors in China has shown an upward trajectory, posing significant challenges to their treatment. It is necessary to pay attention to tertiary prevention, start from the perspective of high-risk groups and high-risk factors to reduce the burden of disease, and achieve "early detection, early diagnosis, and early treatment".

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Section: Discussionmentioning

confidence: 99%

Analysis and prediction of central nervous system tumor burden in China during 1990–2030

Qi,

Yu,

Chen

et al. 2024

PLoS ONE

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“…Brain and other central nervous system (CNS) cancers are among the most fatal malignant tumors [1]. The standard modalities for treating these tumors are surgery, radiation therapy, and chemotherapy [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…Some studies have reported a number of various strategies to improve the radiotherapeutic efficacy or ameliorate the ionizing radiation-induced toxicity, including (1) the combination of radiation therapy with other cancer treatment modalities (e.g., surgery or chemotherapy), which the aim of the combined therapy is the enhancement of tumor cell sensitivity to radiation therapy [12,13]; (2) the use of advanced radiation therapy techniques (e.g., stereotactic radiosurgery, stereotactic radiotherapy, intensity-modulated radiation therapy, or image-guided radiation therapy) which can result in a more radiation dose to the tumor without an increase in the radiation dose to the surrounding normal organs [13]; and (3) the use of herbal and natural products as radioprotective and radiosensitizing agents for reducing the radiation therapy-induced toxicity [14][15][16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Protective Potentials of Alpha-Lipoic Acid against Ionizing Radiation-Induced Brain Damage in Rats

Alameri

Zabibah

et al. 2023

Oxidative Medicine and Cellular Longevity

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Background. This study was aimed at determining the effects of alpha-lipoic acid on ionizing irradiation-induced oxidative damage and apoptosis in the brain of rats. Methods. The animals were exposed to whole-brain X-radiation with a 15 Gy single dose in the absence or presence of alpha-lipoic acid (200 mg/kg body weight) pretreatment for one week. The rats were divided into four groups (5 rats in each group): vehicle control, alpha-lipoic acid alone (ALA), radiation alone (RAD), and radiation plus alpha-lipoic acid (RAD+ALA). In the next stage, malondialdehyde (MDA), nitric oxide, catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the brain tissue of the rats were measured. Furthermore, the Western blot analysis technique was performed to assess the NOX2, NOX4, and caspase-3 protein expression levels. Results. Twenty-four hours after the irradiation, MDA and nitric oxide levels in the irradiated rats were significantly higher than those in the control group ( p < 0.001 ); however, the pretreatment with alpha-lipoic acid resulted in a significant reduction in these stress oxidative markers ( p < 0.05 ). Moreover, a significant decrease in CAT, SOD, and GPx levels was observed in the radiation group alone compared to the control group ( p < 0.01 ); in contrast, the activities of these antioxidant enzymes significantly increased in the radiation plus alpha-lipoic acid group in comparison to the radiation group alone ( p < 0.05 ). The results of Western blot analysis revealed that NOX2, NOX4, and caspase-3 protein expressions significantly elevated in the irradiated rats compared to the control group ( p < 0.001 ). The pretreatment with alpha-lipoic acid could significantly decrease the expression levels of NOX2, NOX4, and caspase-3 in comparison with the radiation group alone ( p < 0.05 ). Conclusion. According to the obtained findings, it can be mentioned that the alpha-lipoic acid pretreatment could mitigate the ionizing irradiation-induced oxidative damage and apoptosis in the brain of the rats.

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“…In the revised version of the World Health Organization's (WHO) classification of malignancies affecting the central nervous system (CNS) [ 4 , 5 ], gliomas are classified based on combined molecular and histological findings [ 6 ], which include isocitrate dehydrogenase (IDH) mutation, 1p19q codeletion, H3 Lys27Met, and RELA fusion. Despite the development of molecular biology techniques, modern methods for pathogenesis, and diverse treatments of glioma [ 7 ], it is still a fatal disease with a very poor prognosis [ 8 ] and a mortality rate close to 80% in the first year of diagnosis. Through an excessive generation of reactive oxygen species (ROS), oxidative stress (OS) is a significant contributor to the onset and progression of cancers.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Prognostic Analysis of Immune Implication Value and Oxidative Stress Significance of NECAP2 in Low-Grade Glioma

Chen

et al. 2022

Oxidative Medicine and Cellular Longevity

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Adaptin ear-binding coat-associated protein 2 (NECAP2) belongs to the family of proteins encoding adaptin-ear-binding coat-associated proteins. However, its immune effect on tumors and its microenvironment are still unclear. Here, we systematically evaluated the differences (variations) in NECAP2 expression for low-grade glioma (LGG) and pan-cancer in the LGG dataset of The Cancer Genome Atlas (TCGA) utilizing bioinformatics methods. We found for the first time that NECAP2 level was elevated in gliomas and that this upregulation increased as the tumor grade increased. In addition, Pearson correlations of NECAP2 with five immune pathways and significant gene mutations associated with NECAP2 were also analyzed. Univariate survival and multivariate Cox analyses were used to compare the clinical characteristics and survival of the patients. Glioma patients with NECAP2 overexpression have a remarkably higher risk of developing malignant behavior and a worse prognosis. The correlation between the expression levels of NECAP2 and the prognosis of glioma patients was identified. Kaplan-Meier curves showed that patients with upregulated NECAP2 expression exhibited an unfavorable prognosis. Western blotting showed that NECAP2 was overexpressed in glioma patients. IHC staining results illustrated an elevation in the NECAP2 protein expression level with the development of tumor malignancy. Additionally, qRT-PCR verified that oxidative stress in glioma tissues reduced the expression of stress-related genes and oxidative stress capacity compared to normal tissues, which may be associated with tumor evasion of immune surveillance and tumor progression. In vitro wound-healing and Transwell assay confirmed that NECAP2 promotes glioma cell migration and invasion. Our study also thoroughly examined the immune significance of NECAP2 in the TCGA-LGG samples, using CIBERSORT and ESTIMATE to explore the correlation between NECAP2 and cancer immune infiltration. The NECAP2 expression levels were correlated with the infiltration degree of immune cells such as neutrophils, CD4+ T cells, macrophages, CD8+ T cells, and B cells. Therefore, our results indicate that NECAP2 strongly correlates with the overall immune infiltration level of glioma and could independently serve as a prognostic biological marker for glioma patients.

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Guidelines in the management of CNS tumors

Cited by 12 publications

References 192 publications

Analysis and prediction of central nervous system tumor burden in China during 1990–2030

Analysis and prediction of central nervous system tumor burden in China during 1990–2030

Protective Potentials of Alpha-Lipoic Acid against Ionizing Radiation-Induced Brain Damage in Rats

Comprehensive Prognostic Analysis of Immune Implication Value and Oxidative Stress Significance of NECAP2 in Low-Grade Glioma

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