“…Across other included CPGs, while domains one ( scope and purpose ) and four ( clarity of presentation ) were particularly well-addressed, domain five ( applicability ), which addresses factors that may impact a guideline’s implementation, potential impact on resources, and strategies to improve uptake, was very poorly addressed. This finding is not unique to this review, rather, it appears to be a general criticism of many reviews of CPGs published on a variety of topics (e.g., breast cancer [ 63 ], osteoarthritis [ 64 ], and childhood fever [ 65 ]). Given that many factors influence the contextualization of scientific evidence for real-world application (i.e., available resources, cost-effectiveness, and availability of services [ 66 ]), future CPGs (and CPG updates) should consider using a validated framework, such as ADAPTE [ 67 ], to systematically integrate important cultural and organizational contexts during development.…”