Guidelines for the measurement of glomerular filtration rate using plasma sampling

Fleming, John; Zivanovic, Maureen A.; Blake, Glen M.; Burniston, Maria; Cosgriff, P. S.; Nunan, T O

doi:10.1097/00006231-200502000-00017

Cited by 19 publications

(37 citation statements)

References 8 publications

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“…The error induced by this phenomenon is particularly relevant at low levels of GFR. No difference was found between the plasma clearance of 51 Cr-EDTA and of 99m Tc-DTPA (4,5).…”

Section: Measurement Of Glomerular Filtration Ratementioning

confidence: 79%

“…Furthermore, inulin measurement is expensive, cumbersome and not routinely available. Consequently, inulin is only used in research studies when very accurate estimation of renal function is necessary (4,5). Several compounds labeled with radioisotopes have been used for the assessment of GFR.…”

Section: Measurement Of Glomerular Filtration Ratementioning

confidence: 99%

“…Intrinsic to the use of radioactive substances is concern about radiation exposure, particularly in women of child-bearing age. For the substances mentioned above, the whole body radiation exposure achieved as a result of a single clearance measurement with the usual doses is lower than that received from a chest X-ray (4,5). Another important consideration is that the terminal elimination phase is significantly prolonged in advanced renal failure.…”

Section: Measurement Of Glomerular Filtration Ratementioning

confidence: 99%

“…Although they are adequate methods, they are less accurate than two-and multiple-sample methods and may lead to a substantial systematic error in GFR of up to 10-15 mL/min (4,5). 99m Tc-DTPA is a chelate of DTPA and 99m Tc.…”

Section: Measurement Of Glomerular Filtration Ratementioning

confidence: 99%

See 3 more Smart Citations

Monitoring renal function: measured and estimated glomerular filtration rates - a review

Salgado

Neves

Bastos

et al. 2010

Braz J Med Biol Res

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“…The error induced by this phenomenon is particularly relevant at low levels of GFR. No difference was found between the plasma clearance of 51 Cr-EDTA and of 99m Tc-DTPA (4,5).…”

Section: Measurement Of Glomerular Filtration Ratementioning

confidence: 79%

Section: Measurement Of Glomerular Filtration Ratementioning

confidence: 99%

Section: Measurement Of Glomerular Filtration Ratementioning

confidence: 99%

Section: Measurement Of Glomerular Filtration Ratementioning

confidence: 99%

See 2 more Smart Citations

Monitoring renal function: measured and estimated glomerular filtration rates - a review

Salgado

Neves

Bastos

et al. 2010

Braz J Med Biol Res

View full text Add to dashboard Cite

“…11 The Brochner-Mortensen equation was used to correct for the one-compartment assumption. 12 GFR was also scaled to an ECV of 13 l, as described earlier (GFR/ECV), 13 l being the ECV of standard humans (analogous to a standard BSA of 1.73 m 2 ).…”

Section: Methodsmentioning

confidence: 99%

Obesity does not accelerate the decline in glomerular filtration rate associated with advancing age

et al. 2009

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Obesity has been suggested as a risk factor for chronic kidney disease. However, it has also been suggested that the association between obesity and impaired glomerular filtration rate (GFR) arises from the invalid use of body surface area (BSA) for scaling. This study assesses the effect of obesity on GFR by comparing the age-dependent decline in obese (body mass index (BMI) 430 kg/m 2 ; n ¼ 149) and non-obese patients (n ¼ 589), aged 430 years, referred for measurement of GFR (Cr-51-EDTA and three blood samples). GFR was scaled to a BSA of 1.73 m 2 (GFR/BSA) and extracellular fluid volume of 13 l (GFR/ECV), both corrected for the one-compartment assumption. When non-obese patients were categorized into 10-year age brackets (from 31 to 470), GFR/BSA and GFR/ECV declined from 92 ml per min per 1.73 m 2 and 95 ml per min per 13 l, respectively, at 31-40 years to 58 and 59 at 470. The declines in obese patients were similar with corresponding values of 88 ml per min per 1.73 m 2 and 97 ml per min per 13 l at 31-40 and 57 and 59 at 470 years. Linear regression analysis of non-categorized data from age 40 years showed rates of decline slightly slower in the obese (0.82 vs 0.95 ml per min per 1.73 m 2 per year and 0.87 vs 1.02 ml per min per 13 l per year). No effect of obesity on renal function was shown. Scaling to BSA did not distort the results.

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Glomerular filtration rate estimation in patients with type 2 diabetes: creatinine- or cystatin C-based equations?

et al. 2011

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Aims/hypothesis It is argued that GFR estimation (eGFR) using cystatin C-based equations (eGFRcys) is superior to that using creatinine-based equations (eGFRcre). We investigated whether eGFRcys are superior to eGFRcre in patients with type 2 diabetes. Methods GFR was measured in 448 type 2 diabetic patients using 51 Cr-EDTA-measured GFR (mGFR) as the reference standard. Bias, precision and accuracy of eGFRcys and eGFRcre were compared. Results The most accurate eGFRcre equation (Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI]), which produced the highest proportion of estimates that were within 30% and 10% of the reference standard (80.7% and 38.0% of samples, respectively) had a bias of 7.1 and precision of 12.0 ml min −1 1.73 m −2 . The calibrated eGFRcys with the highest accuracy (Tan-C), which produced the highest proportion of estimates that were within 30% (78.8%) and within 10% (39.0%) of the reference standard had a bias of −3.5 and precision of 18.0 ml min ) and moderate (mGFR <60 ml min −1 1.73 m −2

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Guidelines for the measurement of glomerular filtration rate using plasma sampling

Cited by 19 publications

References 8 publications

Monitoring renal function: measured and estimated glomerular filtration rates - a review

Monitoring renal function: measured and estimated glomerular filtration rates - a review

Obesity does not accelerate the decline in glomerular filtration rate associated with advancing age

Glomerular filtration rate estimation in patients with type 2 diabetes: creatinine- or cystatin C-based equations?

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