Guidelines for the management of osteoporosis and fragility fractures

Nuti, Ranuccio; Brandi, Maria Luisa; Checchia, Giovanni Antonio; Munno, Ombretta Di; Domínguez, Ligia J.; Falaschi, P.; Fiore, Carmelo Erio; Iolascon, Giovanni; Maggi, Stefania; Michieli, Raffaella; Migliaccio, Silvia; Minisola, Salvatore; Rossini, Maurizio; Sessa, Giuseppe; Tarantino, Umberto; Toselli, Antonella; Isaia, Giovanni Carlo

doi:10.1007/s11739-018-1874-2

Cited by 213 publications

(225 citation statements)

References 95 publications

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“…In postmenopausal women, the anti-fracture efficacy of denosumab has been documented for vertebral fractures, hip fractures and non-vertebral fractures (−68%, −40% and −20%, respectively, over three years of therapy). Moreover, evidence has shown that denosumab also has efficacy in the treatment of patients with breast cancer treated with aromatase inhibitors and men on androgen deprivation therapy for prostate cancer [129].…”

Section: Clinical Management Of Bone Health and Vitamin D Supplementamentioning

confidence: 99%

“…Follow-up of patients should ideally be conducted in the same facility with the same machine. DXA should be repeated every 1 to 2 years until findings are stable [129]. Due to the complexity in the management of osteopenia/osteoporosis in patients with malignant neoplasms, bone assessment and clinical management in GEP-NET patients need a multidisciplinary approach.…”

Section: Clinical Management Of Bone Health and Vitamin D Supplementamentioning

confidence: 99%

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Bone Metabolism and Vitamin D Implication in Gastroenteropancreatic Neuroendocrine Tumors

Altieri¹,

Dato

Modica

et al. 2020

Nutrients

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Patients affected by gastroenteropancreatic–neuroendocrine tumors (GEP–NETs) have an increased risk of developing osteopenia and osteoporosis, as several factors impact on bone metabolism in these patients. In fact, besides the direct effect of bone metastasis, bone health can be affected by hormone hypersecretion (including serotonin, cortisol, and parathyroid hormone-related protein), specific microRNAs, nutritional status (which in turn could be affected by medical and surgical treatments), and vitamin D deficiency. In patients with multiple endocrine neoplasia type 1 (MEN1), a hereditary syndrome associated with NET occurrence, bone damage may carry other consequences. Osteoporosis may negatively impact on the quality of life of these patients and can increment the cost of medical care since these patients usually live with their disease for a long time. However, recommendations suggesting screening to assess bone health in GEP–NET patients are missing. The aim of this review is to critically analyze evidence on the mechanisms that could have a potential impact on bone health in patients affected by GEP–NET, focusing on vitamin D and its role in GEP–NET, as well as on factors associated with MEN1 that could have an impact on bone homeostasis.

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Section: Clinical Management Of Bone Health and Vitamin D Supplementamentioning

confidence: 99%

Section: Clinical Management Of Bone Health and Vitamin D Supplementamentioning

confidence: 99%

Bone Metabolism and Vitamin D Implication in Gastroenteropancreatic Neuroendocrine Tumors

Altieri¹,

Dato

Modica

et al. 2020

Nutrients

View full text Add to dashboard Cite

show abstract

“…Osteoporosis is generally divided into two forms, primary osteoporosis and secondary osteoporosis. The primary osteoporosis mainly contains three categories, juvenile, postmenopausal, and senile the senile osteoporosis has become one significant health concern of the world as it is an age-related disorder that occurs in people's 70s, leading to the attenuation of both the cortical and trabecular bones [6].…”

Section: Introductionmentioning

confidence: 99%

Senile Osteoporosis: The Involvement of Differentiation and Senescence of Bone Marrow Stromal Cells

Qadir

Liang

et al. 2020

IJMS

134

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Senile osteoporosis has become a worldwide bone disease with the aging of the world population. It increases the risk of bone fracture and seriously affects human health. Unlike postmenopausal osteoporosis which is linked to menopause in women, senile osteoporosis is due to aging, hence, affecting both men and women. It is commonly found in people with more than their 70s. Evidence has shown that with age increase, bone marrow stromal cells (BMSCs) differentiate into more adipocytes rather than osteoblasts and undergo senescence, which leads to decreased bone formation and contributes to senile osteoporosis. Therefore, it is necessary to uncover the molecular mechanisms underlying the functional changes of BMSCs. It will benefit not only for understanding the senile osteoporosis development, but also for finding new therapies to treat senile osteoporosis. Here, we review the recent advances of the functional alterations of BMSCs and the related mechanisms during senile osteoporosis development. Moreover, the treatment of senile osteoporosis by aiming at BMSCs is introduced.

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“…Peripheral measurements of the forearm are reserved for special circumstances, particularly for patients in whom lumbar or femoral evaluation is not possible or not accurate, and those who are severely obese or suffer from primary hyperparathyroidism. 27 This is an epidemiological study that enrolled large groups of people, including obese subjects. Due to financial, place, and time constraints, we are unlikely to measure BMD at all sites.…”

Section: Discussionmentioning

confidence: 99%

Association Between Forearm Bone Mineral Density and Metabolic Obesity in a Northern Chinese Population

Wang

Chen

Wang

et al. 2020

Metabolic Syndrome and Related Disorders

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Context: The link between obesity and bone health is controversial. Most studies classify obesity based on body mass index. However, differences in metabolic status may affect bone health. Purpose: To explore the potential relationship of metabolic obesity with forearm bone mineral density (BMD) in a northern Chinese population. Methods: This is a retrospective study involving a total of 2122 subjects divided into four groups: a metabolically healthy normal-weight (MHNW) group, a metabolically healthy obesity (MHO) group, a metabolically unhealthy, but normal-weight (MUNW) group, and a metabolically unhealthy obesity (MUO) group. Analysis of covariance was performed to compare forearm BMD among the groups. The covariates included age, weight, and height, along with menopause status in women. Partial correlation analysis and multiple linear regression models were used to explore the associations of forearm BMD with clinical parameters. Results: Young middle-aged men with MHO had significantly higher forearm BMD than those in the MUO group. In addition, forearm BMD of young middle-aged women was higher in the MHNW group than in the MUNW group. Partial correlation analysis and multiple linear regression analysis suggested that homeostasis model assessment of insulin resistance (HOMA-IR) was negatively correlated with forearm BMD in young middle-aged male subjects with MUO, and waist circumference (WC) and low-density lipoprotein cholesterol (LDL-C) showed a significant negative relationship with forearm BMD in young middle-aged female MUNW subjects. Conclusions: Men in the MUO group and women in the MUNW group were more likely to have lower forearm BMD if they were of young middle age. Metabolic obesity could be a better method for defining obesity when exploring the relationship between obesity and bone health in Chinese individuals. WC, LDL-C, and insulin resistance might be negative predictors of bone health.

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Guidelines for the management of osteoporosis and fragility fractures

Cited by 213 publications

References 95 publications

Bone Metabolism and Vitamin D Implication in Gastroenteropancreatic Neuroendocrine Tumors

Bone Metabolism and Vitamin D Implication in Gastroenteropancreatic Neuroendocrine Tumors

Senile Osteoporosis: The Involvement of Differentiation and Senescence of Bone Marrow Stromal Cells

Association Between Forearm Bone Mineral Density and Metabolic Obesity in a Northern Chinese Population

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