Guidelines for the diagnosis of rheumatoid arthritis

Mota, Lícia Maria Henrique da; Cruz, Bóris Afonso; Brenol, Claiton Viegas; Pereira, Ivânio Alves; Rezende-Fronza, Lucila Stange; Bértolo, Manoel Barros; Freitas, Marcos Rabelo de; Silva, Nílzio Antônio da; Louzada‐Júnior, Paulo; Giorgio, Rina Dalva Neubarth; Lima, Rodrigo Aires Corrêa; Kairalla, Ronaldo Adib; Kawassaki, Alexandre de Melo; Bernardo, Wanderley Marques; Pinheiro, Geraldo da Rocha Castelar

doi:10.1016/s2255-5021(13)70019-1

Cited by 13 publications

(4 citation statements)

References 141 publications

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“…Hence, both of these known cases showed the typical traits described in the clinical literature: erosive polyarticular symmetric lesions affecting the hand and wrist bones as well as other more distant joints (here, the elbows). These traits are recognized characteristics of RA () and used in the differential diagnosis of previous studies . Moreover, they both lacked the same features that would have indicated other diseases included in the differential diagnosis: sacroiliac fusion, spinal fusion, asymmetric involvement, fibrocartilaginous entheses, oligoarthritis, DIP joints involvement, and bone debris.…”

Section: Discussionmentioning

confidence: 99%

“…In terms of pathogenesis, RA is a progressive, systemic, chronic, and inflammatory arthropathy . The infiltration in the synovium of leukocytes induces an inflammation or «synovitis».…”

mentioning

confidence: 99%

“…In the palaeopathological literature, RA is defined as erosive with minimal to absent new bone formation . The lesions are articular or para‐articular, polyarticular, and symmetric . RA typically affects the small joints of the wrist and hands including carpal joints, carpometacarpal joints, metacarpophalangeal joints (MCP), metatarsophalangeal joints (MTP), proximal interphalangeal joints (PIP) and may spread to more distant weight‐bearing joints ().…”

mentioning

confidence: 99%

“…RA typically affects the small joints of the wrist and hands including carpal joints, carpometacarpal joints, metacarpophalangeal joints (MCP), metatarsophalangeal joints (MTP), proximal interphalangeal joints (PIP) and may spread to more distant weight‐bearing joints (). The arthropathy is also characterized by a relative sparing of distal interphalangeal joints (DIP) and of sacroiliac as well as spinal fusion . RA can also cause erosions of the odontoid process leading to subluxations and dislocations , ulnar deviation of the bones of the hand , and possible « pencil‐in‐cup » deformities .…”

mentioning

confidence: 99%

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The Diagnostic Implications of Two Cases of Known Rheumatoid Arthritis from the CAL Milano Cemetery Skeletal Collection

Biehler‐Gomez

Cattaneo

2018

Journal of Forensic Sciences

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Rheumatoid arthritis (RA) is the most common erosive arthropathy and is of particular interest to forensic sciences. However, its diagnosis on bones remains challenging. We examined two skeletons from the CAL Milano Cemetery Skeletal Collection diagnosed with the pathology during life, to test the validity of the diagnostic criteria on bones. The first showed typical lesions of RA described in the literature. The second exhibited secondary osteoarthrosis, suggesting long-standing RA. A differential diagnosis including all four seronegative spondyloarthropathies, erosive osteoarthritis, gout and neuropathic arthropathy was also considered. Both shared common features consistent with the literature: symmetric erosions of bones in the hands, wrists and elbows, sparing of the distal interphalangeal joints, and the absence of sacroiliac and spinal fusion. Given the paucity of studies on known RA skeletons, these results strengthen the criteria for diagnosis. This research is, to our knowledge, the first study on identified and known individuals with RA.

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Section: Discussionmentioning

confidence: 99%

“…In terms of pathogenesis, RA is a progressive, systemic, chronic, and inflammatory arthropathy . The infiltration in the synovium of leukocytes induces an inflammation or «synovitis».…”

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The Diagnostic Implications of Two Cases of Known Rheumatoid Arthritis from the CAL Milano Cemetery Skeletal Collection

Biehler‐Gomez

Cattaneo

2018

Journal of Forensic Sciences

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The synergy between radiographic and macroscopic observation of skeletal lesions on dry bone

et al. 2019

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Cardiovascular risk and mannose binding lectin in patients with rheumatoid arthritis from southern Brazil

Kahlow

Nisihara

Petisco

et al. 2018

IJC Heart & Vasculature

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BackgroundMannose binding lectin (MBL) appears to be involved in susceptibility to rheumatoid arthritis (RA), in the inflammatory process and in the genesis of atherosclerotic disease.ObjectiveTo study the association of MBL serum levels and its genotypic variation with carotid arteries intimal thickness (IMT) in RA patients from Southern Brazil.MethodsMBL serum levels, MBL2 genotyping and IMT were investigated in 90 RA patients along with their demographic, clinical and laboratory profile. MBL levels and MBL2 genotyping were evaluated in 90 healthy controls.ResultsA significant lower MBL serum concentration was observed in patients with RA in relation to controls (528 ng/mL vs 937.5 ng/mL, p = 0.05, respectively). The median IMT in RA patients was 0.59 mm (0.51 to 0.85 mm). There was no correlation between levels of MBL with disease activity, erythrocyte sedimentation rate, autoantibodies presence or IMT (p = NS). A weak and negative correlation was found between MBL and CRP levels (Rho = −0.24; p = 0.02;). The MBL2 variant at codon 54 (variant B) and HYPA haplotype were the most frequently observed in the RA sample (67.5% and 31.7%). MBL2 wild type (A/A) were associated with lower IMT when compared with heterozygotes (A/O; p = 0.04) and low producers (O/O; p = 0.05). In addition, high producers genotypes had lower levels of CRP when compared with medium (p = 0.04) or with low producers (p = 0.05).ConclusionRA patients had lower MBL levels than controls. MBL were negatively associated with CRP serum levels; low MBL genotypes producers increased thickness of the IMT than high producers.

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Guidelines for the diagnosis of rheumatoid arthritis

Cited by 13 publications

References 141 publications

The Diagnostic Implications of Two Cases of Known Rheumatoid Arthritis from the CAL Milano Cemetery Skeletal Collection

The Diagnostic Implications of Two Cases of Known Rheumatoid Arthritis from the CAL Milano Cemetery Skeletal Collection

The synergy between radiographic and macroscopic observation of skeletal lesions on dry bone

Cardiovascular risk and mannose binding lectin in patients with rheumatoid arthritis from southern Brazil

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