The Diagnostic Implications of Two Cases of Known Rheumatoid Arthritis from the <scp>CAL</scp> Milano Cemetery Skeletal Collection

Biehler‐Gomez, Lucie; Cattaneo, Cristina

doi:10.1111/1556-4029.13799

Cited by 8 publications

(2 citation statements)

References 55 publications

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“…8). This finding has sometimes been considered diagnostic of RA Aufderheide and Rodríguez-Martín, 1998;Biehler-Gomez and Cattaneo, 2018), although it is probably non-specific evidence of the condition (as reported by Fletcher and Rowley, 1952).…”

Section: Discussionmentioning

confidence: 92%

“…The axial skeleton is affected to a lesser extent: the cervical spine is known to be generally involved in rheumatoid spondylitis Bywaters, 1981;, possibly producing fusion of the upper cervical vertebrae that, according to , occurs in about 17% of RA patients. Juxta-articular osteopenia, resulting from erosive lesions and osteoclast activation, is another common feature of the disease (Aufderheide and Rodríguez-Martín, 1998;Biehler-Gomez and Cattaneo, 2018). Necessary for the diagnosis is the presence of bones of hands and feet that exhibit early manifestations of the disease .…”

Section: Discussionmentioning

confidence: 99%

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A case of erosive polyarthropathy from Medieval northern Italy (12th–13th centuries)

Tesi

Giuffra

Fornaciari

et al. 2019

International Journal of Paleopathology

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Objective: To evaluate and differentially diagnose erosive skeletal lesions located on multiple joints of an individual archaeologically recovered in 2017. Materials: Skeletal remains of a well-preserved skeleton dating to the 12th-13th centuries from the Medieval church of San Biagio in Cittiglio (Varese, northern Italy). Methods: Macroscopic and radiographic imaging. Results: Erosive marginal symmetrical lesions are present on the metatarsophalangeal, metacarpophalangeal and interphalangeal joints of an adult male, aged 55-75 years. Osteolytic changes, in the form of pocket erosions, surface resorptions, and pseudocyst formations, are also macroscopically observed on some carpal and tarsal bones and on several large peripheral joints. Conclusions: A careful differential diagnosis of the lesions and their macroscopic and radiological appearance are suggestive of a case of rheumatoid arthritis-like polyarthropathy. Significance: This case contributes to the debate regarding the antiquity of erosive polyarthropathies, providing additional evidence for the existence of these diseases in the Old World prior to the discovery of the Americas. Limitations: Small sample size limits the discussion of the scope of the disease in antiquity. Suggestions for Further Research: This case highlights the need for further macroscopic, radiographic, and biomolecular studies of premodern European skeletal samples to investigate the hypothesized pre-existence of these pathological conditions in Europe prior to 1492.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

A case of erosive polyarthropathy from Medieval northern Italy (12th–13th centuries)

Tesi

Giuffra

Fornaciari

et al. 2019

International Journal of Paleopathology

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Multivariate assessments of activity‐related skeletal changes: Interpreting Bell Beaker specialized male archery and social organization in Central Europe

Ryan‐Despraz

Villotte

Desideri

et al. 2023

American Journal of Biological Anthropology

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ObjectivesThe Bell Beaker period witnessed the rise of individual inhumations with “wealthy” burial contexts containing archery‐related grave goods, leading archaeologists to label the individuals in these tombs as “archers.” This study looks to (1) compare the skeletons from male “archer” burials with those from male “non‐archer” burials—those not having archery‐related grave goods—in order to assess a possible link between burial context and physical activity, and (2) apply a biomechanics profile to evaluate whether the individuals associated with these “archer” burials practiced specialized archer activity.Materials and MethodsThe corpus (males only) included 46 “archers” and 40 “non‐archers” from Bell Beaker individual inhumations. Osteological data included measurements, scores of entheseal changes, and a diagnosis of certain pathologies. Data analyses involved visual observations, hypothesis tests, dimension reduction, and MANOVA, with approaches aimed at exploring the treatment of data missingness.ResultsMeasurement data revealed no differences between the two groups. Evaluations of entheseal changes found that “non‐archers” had consistently more instances of bone surface modifications than “archers.” Individual assessments of specialized archer occupation identified 11 possible specialized archers.DiscussionThese findings indicate a possible labor differentiation represented through the presence of a probably prestigious “archer” burial context. This suggests a link between grave good presence and labor, but not between a Bell Beaker archery occupation and an “archer” burial context. Data analyses support the application of biomechanics to osteological analyses in order to assess specialized activity on the skeleton.

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Diabetic bone lesions: a study on 38 known modern skeletons and the implications for forensic scenarios

et al. 2018

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Diabetes mellitus is a condition with severe and life-threatening complications and epidemic proportions worldwide. The study of diabetes on bones can provide crucial information to the forensic practice, the archeological field and medical research. In this paper, the authors report and discuss the lesions observed on the skeletons of 38 individuals (plus 11 negative control samples) of the CAL Milano Cemetery Skeletal Collection with known diabetes. As a result, different types of lesions were highlighted in the feet: periosteal new bone formation, lysis of tuft, lytic lesions, evidence of trauma, osteomyelitis, and osteochondritis dissecans. In 50% of the skeletons of the study sample, lesions were located on bones of the first ray of the foot. Vascular calcifications were also collected and considered. None of these lesions is pathognomonic of diabetes and each implies a broad differential diagnosis that can be confronted with the upper and axial lesions. However, they are coherent with the disease development and complications. This study is the first to document skeletons with known diabetes from an identified collection and discuss their diagnostic potential.

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The Diagnostic Implications of Two Cases of Known Rheumatoid Arthritis from the CAL Milano Cemetery Skeletal Collection

Cited by 8 publications

References 55 publications

A case of erosive polyarthropathy from Medieval northern Italy (12th–13th centuries)

A case of erosive polyarthropathy from Medieval northern Italy (12th–13th centuries)

Multivariate assessments of activity‐related skeletal changes: Interpreting Bell Beaker specialized male archery and social organization in Central Europe

Diabetic bone lesions: a study on 38 known modern skeletons and the implications for forensic scenarios

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