Guidelines for radioiodinated MIBG scintigraphy in children

Abstract

These guidelines on the use of radioiodinated (99m)Tc-MIBG scintigraphy in children, which summarise the views of the Paediatric Committee of the European Association of Nuclear Medicine, provide a framework which may prove helpful to nuclear medicine teams in daily practice. They have been influenced by the conclusions of the "Consensus Guidelines for MIBG Scintigraphy" (Paris, November 6, 1997) of the European Neuroblastoma Group and by those of the Oncological Committee of the French Society of Nuclear Medicine. The guidelines should be taken in the context of "good practice" and any local/national rules which apply to nuclear medicine examinations.

Characterization of Neuroblastic Tumors Using 18F-FDOPA PET

“…18 F-FDOPA PET was well tolerated in children with neuroblastic tumors. The 90-min interval between 18 F-FDOPA injection and PET scanning was much shorter than the standard 24-h interval for 123 I-MIBG scans (26) and allowed a single visit of the patient. 18 F-FDOPA PET clearly visualized primary and metastatic neuroblastic tumors ( Fig.…”

Recognition of Abnormal Uptake through 123I-mIBG Scintigraphy Entropy for Paediatric Neuroblastoma Identification

“…A scintigraphic image is a representation of the radioactive distribution inside the body. Peaks of higher intensity than expected are the main variable analyzed by radiologists when identifying the uptake regions [2].…”

Criteria for evaluation of disease extent by 123I-metaiodobenzylguanidine scans in neuroblastoma: a report for the International Neuroblastoma Risk Group (INRG) Task Force

“…For details on the mIBG scan procedure, refer Shulkin and Shapiro (1998), Olivier et al (2003) and Bombardieri et al (2003).…”

“…Thyroid blockade for 123 I-mIBG scans can be achieved using aqueous iodine solution, oral potassium iodide (100 mg adult or 2 mg kg -1 children) or potassium iodate commencing 2 -24 h before radiopharmaceutical injection and continuing for 1 day after, in accordance with local protocols or the European guidelines (Olivier et al, 2003). If a patient is allergic to iodine, oral potassium perchlorate may be substituted, given three times daily starting 2 -24 h before and continuing for 2 days after, at a dose of 8 mg kg -1 (400 mg for adult).…”