Guided ultrasound wave propagation in intact and healing long bones

Protopappas, Vasilios C.; Fotiadis, Dimitrios I.; Malizos, Konstantinos N.

doi:10.1016/j.ultrasmedbio.2006.02.001

Cited by 125 publications

(95 citation statements)

References 32 publications

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“…The FAS velocity was found to decrease during the first healing stages and gradually to increase in later healing stages approximating the values of intact bone (Protopappas et al 2006). Moreover, the FAS velocity measured in small propagation paths was found to decrease with increasing the porosity reflecting changes in cortical porosity.…”

Section: Discussionmentioning

confidence: 70%

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Computational Modeling of Long Bone Microstructure and Ultrasonic Evaluation of the Fracture Healing Process

Potsika¹,

Polyzos²,

Fotiadis³

2017

JSSCM

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Bone is a composite medium organized into a complex hierarchical structure. Several research groups worldwide have applied ultrasonic techniques to investigate experimentally and numerically the structure of bone at different hierarchical levels. The advance in imaging modalities such as micro-computed tomography and scanning acoustic microscopy in combination with the use of robust computational tools has led to the development of realistic computational models of long bones. The ultrasonic assessment of bone microstructure and fracture healing using computational techniques can provide insight into complicated wave propagation effects which cannot be evaluated using traditional experimental procedures. This paper presents the milestone studies in the domain of ultrasonic evaluation of bone diseases such as osteoporosis and bone healing using numerical methods. The results indicate the significant diagnostic and monitoring role of quantitative ultrasound.

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Section: Discussionmentioning

confidence: 70%

“…In, (Dodd et al 2007, Dodd et al 2008, Protopappas et al 2006, 2D isotropic models of healing long bones were presented in which the material properties of callus were varying to simulate different healing stages. The FAS velocity and attenuation were calculated using the axial transmission method.…”

Section: Computational Modeling Of the Fracture Healing Processmentioning

confidence: 99%

Computational Modeling of Long Bone Microstructure and Ultrasonic Evaluation of the Fracture Healing Process

Potsika¹,

Polyzos²,

Fotiadis³

2017

JSSCM

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“…While in most studies investigators have focused attention on the measurement of the velocity of the earliest component of the signal recorded at the receivers, the so-called first arriving signal (FAS), 1 several studies in the past decade reported approaches to measure different signal components, such as the fundamental flexural GW, 3,6,7 or higher order GW dispersion curves. 8,9 In particular, measuring GW frequency-dependent wavenumbers is expected to provide a more complete view of the biomechanical status of bone compared to FAS velocity measurements alone. From the measurements of GW propagation, the geometrical and elastic properties can be recovered by corresponding frequency-dependent wavenumbers and (ii) inverting these data by fitting of an appropriate waveguide model.…”

Section: Introductionmentioning

confidence: 99%

Accurate measurement of guided modes in a plate using a bidirectional approach

Moreau

Minonzio

Foiret

et al. 2013

The Journal of the Acoustical Society of America

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International audienceMeasuring guided wave propagation in long bones is of interest to the medical community. When an inclination exists between the probe and the tested specimen surface, a bias is introduced on the guided mode wavenumbers. The aim of this study was to generalize the bidirectional axial transmission technique initially developed for the first arriving signal. Validation tests were performed on academic materials such a bone-mimicking plate covered with either a silicon or fat-mimicking layer. For any inclination, the wavenumbers measured with the probe parallel to the waveguide surface can be obtained by averaging the wavenumbers measured in two opposite directions

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“…Moreover, since ultrasound is a mechanical wave and interacts with bone in a fundamentally different manner than X-rays, it may be able to provide information on additional components of bone strength, notably its trabecular architecture ( The propagation of ultrasound through bone is a complex phenomenon, for which few analytic characterizations are available. In the past several years, computer simulation has emerged as an extremely useful tool (Kaufman et al 2008a(Kaufman et al , 2008bHaïat et al 2007;Protopappas et al 2006;Hosokawa 2005;Bossy et al 2005;Luo et al 1999). Simulation affords the user with the ability to address a whole host of questions which, as pointed out, have no analytic solution and for which the experimental setting may be very difficult to carry out.…”

Section: Introductionmentioning

confidence: 99%

“…In the past several years, computer simulation has emerged as an extremely useful tool (Kaufman et al 2008a(Kaufman et al , 2008bHaïat et al 2007;Protopappas et al 2006;Hosokawa 2005;Bossy et al 2005;Luo et al 1999). Simulation affords the user with the ability to address a whole host of questions which, as pointed out, have no analytic solution and for which the experimental setting may be very difficult to carry out.…”

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confidence: 99%

Ultrasound Simulation in the Distal Radius Using Clinical High-Resolution Peripheral-CT Images

Floch

McMahon

Luo

et al. 2008

Ultrasound in Medicine & Biology

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The overall objective of this research is to develop an ultrasonic method for noninvasive assessment of the distal radius. The specific objective of this study was to examine the propagation of ultrasound through the distal radius and determine the relationships between bone mass and architecture and ultrasound parameters. Twenty-six high-resolution peripheral-CT clinical images were obtained from a set of subjects that were part of a larger study on secondary osteoporosis. A single midsection binary slice from each image was selected and used in the two-dimensional (2D) simulation of an ultrasound wave propagating from the anterior to the posterior surfaces of each radius. Mass and architectural parameters associated with each radius, including total (trabecular and cortical) bone mass, trabecular volume fraction, trabecular number and trabecular thickness were computed. Ultrasound parameters, including net time delay (NTD), broadband ultrasound attenuation (BUA) and ultrasound velocity (UV) were also evaluated. Significant correlations were found between NTD and total bone mass (R 2 = 0.92, p < 0.001), BUA and trabecular number (R 2 = 0.78, p < 0.01) and UV and trabecular bone volume fraction (R 2 = 0.82, p < 0.01). There was only weak, statistically insignificant correlation (R 2 < 0.14, p = 0.21) found between trabecular thickness and any of the ultrasound parameters. The study shows that ultrasound measurements are correlated with bone mass and architecture at the distal radius and, thus, ultrasound may prove useful as a method for noninvasive assessment of osteoporosis and fracture risk. KeywordsOsteoporosis; Ultrasound; Radius; Bone mass; Density; Net time delay; BUA; Peripheral-CT; Velocity Osteoporosis is a significant health problem affecting more than 20 million people in the United States and more than 200 million worldwide (Anonymous 2001). Osteoporosis is defined as the loss of bone mass with a concomitant disruption in microarchitecture, leading to an increased risk of fracture (Kanis 2002 The primary method for diagnosing osteoporosis and associated fracture risk relies on bone densitometry to measure bone mass (Kaufman and Siffert 2001). The use of bone mass is based on the well-established thesis that bone strength is strongly related to the amount of bone material present and that a stronger bone in a given individual is associated generally with a lower fracture risk (Johnell et al. 2005). Radiologic densitometry, which measures the (areal) bone mineral density (BMD) at a given site (e.g., hip, spine, forearm) is currently the accepted "gold standard" indicator of bone strength and fracture risk (Johnell et al. 2005;Blake and Fogelman 2003). Clinically, this is often done using dual energy X-ray absorptiometry (DXA), which measures the BMD in units of g/cm 2 (Blake and Fogelman 2003). Recently, high resolution peripheral-CT imaging has become available for clinical research studies and has led to renewed interest in the distal radius for a better understanding of the relationship betw...

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Guided ultrasound wave propagation in intact and healing long bones

Cited by 125 publications

References 32 publications

Computational Modeling of Long Bone Microstructure and Ultrasonic Evaluation of the Fracture Healing Process

Computational Modeling of Long Bone Microstructure and Ultrasonic Evaluation of the Fracture Healing Process

Accurate measurement of guided modes in a plate using a bidirectional approach

Ultrasound Simulation in the Distal Radius Using Clinical High-Resolution Peripheral-CT Images

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