Guided Bone Regeneration at the Donor Site of Iliac Bone Grafts for Future Use as Autogenous Grafts

Elshahat, Ahmed; Inoue, Nozumu; Marti, Guy; Safe, Ikram; Manson, Paul N.; Vanderkolk, Craig A.

doi:10.1097/01.prs.0000178783.44190.ec

Cited by 10 publications

(8 citation statements)

References 44 publications

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“…Theb one plate combined with titanium cage wasp artiallyw rapped with remaining periosteum, sinceinyoung sheep theperiosteum is usuallyt hicka nd easilyi dentified. Thef indingso fs ome othere xperimental studiessuggested that theperiosteumcan be consideredanatural membrane to guide bone regeneration, butitisnecessary to place some typeo fi mplant, such as our titanium cage, within the defect to preventcollapse (14,15). The latterwas represented, in the report presented herein, by the perforated titanium cage.…”

Section: Discussionsupporting

confidence: 49%

Tibial segmental bone defect treated with bone plate and cage filled with either xenogeneic composite or autologous cortical bone graft

Teixeira

Rahal²,

Volpi³

et al. 2007

Vet Comp Orthop Traumatol

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Tibia segmental defect healing in sheep were clinically, radiographically and histologically evaluated. Twelve young sheep aged four to five months were divided into two groups, G1 and G2. A 3.5 cm long segmental defect was created in the right tibial diaphysis with maintenance of the periosteum. The bone defects in both groups were stabilized with a bone plate combined with a titanium cage. In G1 the cage was filled with pieces of autologous cortical bone graft. In G2 it was filled with a composite biomaterial which consisted of inorganic bovine bone, demineralized bovine bone, a pool of bovine bone morphogenetic proteins bound to absorbable ultra-thin powdered hydroxyapatiteand bone-derived denaturized collagen. Except for one G1 animal, all of them showed normal limb function 60 days after surgery. Radiographic examination showed initial formation of periosteal callus in both groups at osteo-tomy sites, over the plate or cage 15 days postoperatively. At 60 and 90 days callus remodeling occurred. Histological and morphometric analysis at 90 days after surgery showed that the quantity of implanted materials in G1 and G2 were similar, and the quantity of new bone formation was less (p = 0.0048) and more immature in G1 than G2, occupying 51 +/- 3.46% and 62 +/- 6.26% of the cage space, respectively. These results suggest that the composite biomaterial tested was a good alternative to autologous cortical bone graft in this experimental ovine tibial defect. However, additional evaluation is warranted prior to its clinical usage.

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Section: Discussionsupporting

confidence: 49%

Tibial segmental bone defect treated with bone plate and cage filled with either xenogeneic composite or autologous cortical bone graft

Teixeira

Rahal²,

Volpi³

et al. 2007

Vet Comp Orthop Traumatol

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“…The no need for a barrier membrane in the proposed protocol significantly reduced the surgical time and cost and may be attributed to enhanced bone regeneration as the periosteum was not isolated from the grafted site. Periosteum has been shown to play a pivotal role in bone graft incorporation, healing, and remodeling, as it contains multipotent mesenchymal stem cells that are capable of differentiating into bone and cartilage and provides a source of blood vessels and growth factors [ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Protocol for Bone Augmentation with Simultaneous Early Implant Placement: A Retrospective Multicenter Clinical Study

Fairbairn

Leventis

2015

International Journal of Dentistry

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Purpose. To present a novel protocol for alveolar bone regeneration in parallel to early implant placement. Methods. 497 patients in need of extraction and early implant placement with simultaneous bone augmentation were treated in a period of 10 years. In all patients the same specific method was followed and grafting was performed utilizing in situ hardening fully resorbable alloplastic grafting materials consisting of β-tricalcium phosphate and calcium sulfate. The protocol involved atraumatic extraction, implant placement after 4 weeks with simultaneous bone augmentation, and loading of the implant 12 weeks after placement and grafting. Follow-up periods ranged from 6 months to 10 years (mean of 4 years). Results. A total of 601 postextraction sites were rehabilitated in 497 patients utilizing the novel protocol. Three implants failed before loading and three implants failed one year after loading, leaving an overall survival rate of 99.0%. Conclusions. This standardized protocol allows successful long-term functional results regarding alveolar bone regeneration and implant rehabilitation. The concept of placing the implant 4 weeks after extraction, augmenting the bone around the implant utilizing fully resorbable, biomechanically stable, alloplastic materials, and loading the implant at 12 weeks seems to offer advantages when compared with traditional treatment modalities.

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“…However, there was soft tissue ingrowth, which probably explains why less bone was generated. Other studies have shown that an occlusive barrier can be negative factor in bone healing and that perforated material is preferable to allow the periosteum to play a part in the initial mineralization and remodelling of the grafted area (Elshahat et al 2005; Zhang et al 2008). In contrast, a rabbit study has shown that membrane permeability is not essential in guided generation of new bone (Schmid et al 1994).…”

Section: Discussionmentioning

confidence: 99%

Guided bone generation in a rabbit mandible model after periosteal expansion with an osmotic tissue expander

Abrahamsson

Isaksson

Andersson

2011

Clinical Oral Implants Research

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Guided Bone Regeneration at the Donor Site of Iliac Bone Grafts for Future Use as Autogenous Grafts

Abstract: The periosteum acted as an ideal membrane for guided bone regeneration so that the polytetrafluoroethylene membranes could be used only to compensate for the deficient periosteum. Space maintenance was essential for bone regeneration.

Cited by 10 publications

References 44 publications

Tibial segmental bone defect treated with bone plate and cage filled with either xenogeneic composite or autologous cortical bone graft

Tibial segmental bone defect treated with bone plate and cage filled with either xenogeneic composite or autologous cortical bone graft

Protocol for Bone Augmentation with Simultaneous Early Implant Placement: A Retrospective Multicenter Clinical Study

Guided bone generation in a rabbit mandible model after periosteal expansion with an osmotic tissue expander

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