Guide to Drug dosage in Renal Failure1

Wm, Bennett

doi:10.2165/00003088-198815050-00005

Cited by 59 publications

(22 citation statements)

References 239 publications

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“…However, inspection of the iso niazid blood levels illustrated in their paper shows that the apparent isoniazid half-life was probably between 5 and 8 h. Furthermore, the napthoquinone method that they em ployed to estimate isoniazid was non-specific and inher ently unsuitable for determining the drug in the presence of co-administered /x-amino-salicylic acid [77]. For the reasons already given, suggestions that isoniazid dosing intervals should be 8-hourIy [78,79] are also unwarranted. There is also no justification for insisting on plasma isoniazid esti mations [74,80], which are demanding in equipment and skill [44,81] …”

Section: Isoniazid: Treatment Recommendationsmentioning

confidence: 99%

Chemotherapy of Tuberculosis for Patients with Renal Impairment

Ellard¹

1993

Nephron

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Section: Isoniazid: Treatment Recommendationsmentioning

confidence: 99%

Chemotherapy of Tuberculosis for Patients with Renal Impairment

Ellard¹

1993

Nephron

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“…In our patients this effect lasted at least 24 h. It should be stressed that metoclopramide has a half-life of about 4-5 h (in uremia up to 14-18 h) and ondansetron one of about 3-4 h (in uremia 5-9 h), so that a carryover phenomenon of these two drugs is excluded beyond any reasonable doubt after 48 h [14].…”

Section: Discussionmentioning

confidence: 48%

Comparison of Ondansetron with Metoclopramide in the Symptomatic Relief of Uremia-Induced Nausea and Vomiting

Ljutić

Perković

Rumboldt

et al. 2002

Kidney Blood Press Res

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Background: Nausea and vomiting are well-known gastrointestinal complications in chronic renal failure and are frequent indications for the commencement of dialysis. Although the administration of antiemetic drugs (metoclopramide and, recently, ondansetron) is usually mentioned, there are scanty data on their effects. Methods: A double-blind crossover study was done in 10 uremic patients. All the patients were uremic and suffered from nausea and vomiting. The drugs were randomly administered intravenously (either metoclopramide 10 mg or ondansetron 8 mg) 2 h after blood drawing for laboratory tests either on the 1st or on the 3rd study day at the same time. The outcomes were scored after 24 h of follow-up by (1) one of us (D.P.; 1–3 points: 1 = no effect; 2 = moderate effect – decreased frequency of vomiting, and 3 = good effect – no vomiting), and (2) by the patients (1–5 points). Results: The results obtained showed that ondansetron was more effective in controlling nausea and vomiting than metoclopramide, either objectively (2.80 ± 0.422 vs. 1.40 ± 0.699, p < 0.005) or subjectively (4.10 ± 0.738 vs. 2.10 ± 0.994, p < 0.005). Conclusions: We conclude that at the dosage level studied ondansetron is about twice as effective as metoclopramide in the symptomatic relief of uremia-induced nausea and vomiting.

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“…Above all, we want to emphasize that our interests are focused on detecting the reduction in overall renal clearance of the drug including GFR and the tubular secretion, not the reduction in GFR itself. Be cause the age-related decline in both GFR and tubular secretion rate is proportional to the decline in Q 'r [24], measured and predicted Ccr are regarded as the adequate index of the renal clearance of the drug [3,[25][26][27], Occa sionally, concurrent measurement of (32-microglobulin may be helpful in detecting an unexpectedly great discrep ancy between the predicted Ccr and GFR.…”

Section: Discussionmentioning

confidence: 99%

Serum Albumin for Estimating Creatinine Clearance in the Elderly with Muscle Atrophy

Sanaka

Takano²,

Shimakura³

et al. 1996

Nephron

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The present study was conducted to develop a special formula to predict creatinine clearance (C_cr, ml/min) in the elderly with chronic muscle atrophy using serum albumin (Alb, g/dl). We obtained 90 data sets including actual body weight (BW, kg), urinary creatinine excretion (U_cr, mg/24 h), serum creatinine (S_cr, mg/dl), and Alb from 90 inpatients aged 60-92 years. Regression equations were determined between the dependent variable of Uq/BW and the explanatory variable of Alb as follows: For males U_Cr/BW = 2.695Alb + 4.665 For females U_Cr/BW = 1.827Alb + 4.146. Then, the new predictive formula was derived from the equations: For males C_Cr = (19Alb + 32)BW/(100 × S_Cr) For females C_Cr = (13Alb + 29)BW/( 100 × S_Cr). Evaluations for the predictive error (predicted C_cr – measured C_cr) showed that the new formula could provide more accurate and less biased estimates of C_cr than the Cockcroft and Gault formula could, even in patients with renal insufficiency and in those with Alb ≤ 2.8 g/dl.

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Guide to Drug dosage in Renal Failure1

Cited by 59 publications

References 239 publications

Chemotherapy of Tuberculosis for Patients with Renal Impairment

Chemotherapy of Tuberculosis for Patients with Renal Impairment

Comparison of Ondansetron with Metoclopramide in the Symptomatic Relief of Uremia-Induced Nausea and Vomiting

Serum Albumin for Estimating Creatinine Clearance in the Elderly with Muscle Atrophy

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