Using multiple modifiable risk factors from the INTERHEART case-control study, we have developed and validated a simple score for MI risk which is applicable to an international population.
A parental history (PH) of coronary heart disease (CHD) is consistently associated with a higher risk of the development of CHD in several studies (1-9). It is generally accepted that this association is explained by a combination of predominantly known risk factors and genetic variants (10). Although many studies show that risk factors and genetic polymorphisms are significantly associated with myocardial infarction (MI), these studies fail to show how these associations may explain the relationship between PH and the risk of MI (11,12). Some previous studies established the independence of PH from common vascular risk factors (7); however, there are few large international studies that can establish the independence of PH from comprehensive measurements of behavioral, biological, psychosocial, and genetic risk factors, as reported in the INTERHEART study.The aims of this analysis were: 1) to examine whether the risk associated with a score of PH of MI (increasing with the number of affected parents and prematurity of PH) is independent of behavioral, biological, psychosocial, and genetic factors; and 2) to evaluate whether these findings are consistent across sex, age groups, socioeconomic groups, and world regions.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.