2020 DOI: 10.20944/preprints202009.0120.v1 View full text Preprint
Ying Chen, Hisao-Hsien Wang, Hsin-Han Chang, Yun-Hsuan Huang, Jeffrey R. Wang, Chih-Ying Changchien, Sheng-Tang Wu

Abstract: The survival rate and therapeutic options of bladder cancer patients have improved little in recent decades. Guggulsterone (GS), a phytoestrogen, has been investigated as an anticancer drug in various malignancies. The present study aimed to evaluate the anticancer effect of E-isomer and Z-isomer GS in the human bladder cancer cell lines TSGH8301 (low-grade) and T24 (high-grade) and its underlying mechanisms. E-isomer GS reduced the survival rate in both low- and high-grade human bladder cancer cells. Colony f…

expand abstract