Guar gum succinate-sodium alginate beads as a pH-sensitive carrier for colon-specific drug delivery

Seeli, D. Sathya; Thangaraj, Parimelazhagan; Selvamurugan, N.; Prabaharan, M.

doi:10.1016/j.ijbiomac.2016.05.057

Cited by 91 publications

(32 citation statements)

References 20 publications

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“…Thus, these modifications result in reduced EE % as well as antimicrobial efficiency of nisin. As the pKa values of chitosan and alginate (6.2–7 and 3.4–4.4, respectively) (Seeli et al, 2016 ) are existing in the solubility range of nisin, it resulted in better interaction of nisin with these carbohydrate based polymers. The presence of protonated carboxyl groups could promote the electrostatic or hydrophobic interactions of nisin with polymers in the acidic solution, thus increasing its encapsulation efficiency.…”

Section: Resultsmentioning

confidence: 99%

Polyelectrolyte Multicomponent Colloidosomes Loaded with Nisin Z for Enhanced Antimicrobial Activity against Foodborne Resistant Pathogens

et al. 2018

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Food grade micro- or nano-carrier systems (NCS) are being developed to improve the controlled release of antimicrobial agents. To augment the stability of liposomal NCS and to overcome the limitations associated with the use of free bacteriocin (nisin) in the food system, multi-component colloidosomes (MCCS) were developed by electrostatic interactions between anionic alginate and cationic chitosan (multilayer) around phospholipids based liposomes (core). Zeta-sizer results revealed the average diameter of 145 ± 2 nm, 596 ± 3 nm, and 643 ± 5 nm for nano-liposome (NL), chitosomes (chitosan coated NL) and MCCS, respectively. Zeta potential values of NCS varied from −4.37 ± 0.16 mV to 33.3 ± 6 mV, thus both chitosomes (CS) and MCCS were positively charged. Microstructure analysis by scanning electron microscope (SEM) revealed relatively higher size of MCCS with smooth and round morphology. TGA and DSC based experiments revealed that MCCS were thermally more stable than uncoated liposomes. Encapsulation efficiency of nisin in MCCS was observed to be 82.9 ± 4.1%, which was significantly higher than NL (56.5 ± 2.5%). FTIR analyses confirmed the cross-linking between sodium alginate and chitosan layer. Both qualitative (growth kinetics) and quantitative (colony forming unit) antimicrobial assays revealed that nisin loaded MCCS have superior potential to control resistant foodborne pathogens including Staphylococcus aureus, Listeria monocytogenes, and Enterococcus faecalis, (5.8, 5.4, and 6.1 Log CFUmL−1 reduction, respectively) as compared to free nisin, loaded NL or CS. Controlled release kinetics data fitted with Korsmeyer–Peppas model suggested that nisin release from MCCS followed Fickian diffusion. Cytotoxic studies on human blood cells and HepG2 cell lines revealed hemocompatibility and non-toxicity of MCCS. Thus, due to enhanced controlled release, stability and biocompatibility; these multi-component colloidosomes can be useful for incorporating antimicrobial agents into functional foods, beverages and pharmaceutical products to combat pathogenic and spoilage bacteria.

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Section: Resultsmentioning

confidence: 99%

Polyelectrolyte Multicomponent Colloidosomes Loaded with Nisin Z for Enhanced Antimicrobial Activity against Foodborne Resistant Pathogens

et al. 2018

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“…XRD diffractograms showed characteristics diffraction lines of PSS at 2 θ of 6°and 22° due to its crystalline nature are shown in Figure 5 . [ 23 ] Sodium alginate showed well defined peaks at 3° (2 θ ) related to its crystallinity due to strong intermolecular hydrogen bonding [ 24 ] and HPMC K100M at 3°, 9° and 18° (2 θ ). [ 25 ] The diffractograms of tablet of optimized formulation AR9 and raft of AR9 optimized formulation showed many characteristics peaks at 15°, 17°, 19°, 27°, 32° and 40° (2 θ ) but disappearance of the peaks of PSS, sodium alginate and HPMC K100M were observed.…”

Section: Resultsmentioning

confidence: 99%

pH responsive alginate polymeric rafts for controlled drug release by using box behnken response surface design

Abbas

Khan

2016

Designed Monomers and Polymers

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Aim of the present work was to develop alginate raft forming tablets for controlled release pantoprazole sodium sesquihydrate (PSS). Box behnken design was used to optimize 15 formulations with three independent and three dependent variables. Physical tests of all formulations were within pharmacopoeial limits. Raft was characterized by their strength, thickness, resilience, acid neutralizing capacity, floating lag time and total floating time. Raft strength, thickness and resilience of optimized formulation AR9 were 7.43 ± 0.019 g, 5.8 ± 0.245 cm and greater than 480 min, respectively. Buffering and neutralizing capacity were 11.2 ± 1.01 and 6.5 ± 0.56 meq, respectively. Dissolution studies were performed by using simulated gastric fluid pH 1.2 and cumulative percentage release of optimized formulation AR9 was found 98%. First order release kinetics were followed and non-fickian diffusion was observed as value of n was greater than 0.45 in korsmeyer-peppas model. PSS, polymers, tablets and rafts were further characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and differential scanning calorimetry (DSC). FTIR spectra of PSS, polymers and raft of optimized formulation AR9 showed peaks at 3223.09, 1688.17, 1586.67, 1302.64 and 1027.74 cm−1 due to –OH stretching, ester carbonyl group (C=O) stretching, existence of water and carboxylic group in raft, C–N stretching and –OH bending vibration showed no interaction between them. XRD showed diffraction lines indicates crystalline nature of PSS. DSC thermogram showed endothermic peaks at 250 °C for PSS. The developed raft was suitable for controlled release delivery of PSS.

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“…Furthermore, guar gum-based pH-sensitive microparticles for colonspecific drug carriers have been prepared and were found innocuous as indicated by MTT essay studies for cytotoxicity. The drug release studies of Ibuprofen revealed that the % release of Ibuprofen was dependent on pH and drug release was found to increase with increment in pH and vice versa, whereas the neat GG showed no such effect on release (98,166,167).…”

Section: Ph-sensitive Bpsmentioning

confidence: 97%

A glimpse of biodegradable polymers and their biomedical applications

Shah

Vasava

2019

E-Polymers

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Over the past two decades, biodegradable polymers (BPs) have been widely used in biomedical applications such as drug carrier, gene delivery, tissue engineering, diagnosis, medical devices, and antibacterial/antifouling biomaterials. This can be attributed to numerous factors such as chemical, mechanical and physiochemical properties of BPs, their improved processibility, functionality and sensitivity towards stimuli. The present review intended to highlight main results of research on advances and improvements in terms of synthesis, physical properties, stimuli response, and/or applicability of biodegradable plastics (BPs) during last two decades, and its biomedical applications. Recent literature relevant to this study has been cited and their developing trends and challenges of BPs have also been discussed.

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Guar gum succinate-sodium alginate beads as a pH-sensitive carrier for colon-specific drug delivery

Cited by 91 publications

References 20 publications

Polyelectrolyte Multicomponent Colloidosomes Loaded with Nisin Z for Enhanced Antimicrobial Activity against Foodborne Resistant Pathogens

Polyelectrolyte Multicomponent Colloidosomes Loaded with Nisin Z for Enhanced Antimicrobial Activity against Foodborne Resistant Pathogens

pH responsive alginate polymeric rafts for controlled drug release by using box behnken response surface design

A glimpse of biodegradable polymers and their biomedical applications

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