Guajadial inhibits NSCLC growth and migration following activation of the VEGF receptor-2

Wang, Yongfeng; Duan, Meiling; Zhao, Lei; Ma, Ping

doi:10.1016/j.fitote.2018.06.011

Cited by 8 publications

(6 citation statements)

References 15 publications

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“…This potential has been reported as being a significant antineoplasmic activity of 3. The Western blotting method to study the underlying mechanisms of VEGF receptor (VEGFR)2-mediated revealed that compound 3 inhibited A549 (IC 50 = 3.58 µM) proliferation via blocking the Ras/MAPK pathway [34]; this activity of 3 is higher than the potential of cisplatin (IC 50 value of 7.51), which was used as a positive control. Diformylphloroglucinol-based meroterpenoids, viz., guajavadials A-C (4-6) (Figure 2) were obtained from P. guajava and also exhibited cytotoxicity against A-549, HL-60, MCF-7, SMMC-7721, and SW480 cancer cell lines with IC 50 values between 2.28-3.38 µM (Table 1).…”

Section: Phloroglucinol-based Meroterpenoidsmentioning

confidence: 99%

Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology

et al. 2021

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Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways which are produced in part from a terpenoid co-substrate. These mixed biosynthetically hybrid compounds are widely produced by bacteria, algae, plants, and animals. Notably amazing chemical diversity is generated among meroterpenoids via a combination of terpenoid scaffolds with polyketides, alkaloids, phenols, and amino acids. This review deals with the isolation, chemical diversity, and biological effects of 452 new meroterpenoids reported from natural sources from January 2016 to December 2020. Most of the meroterpenoids possess antimicrobial, cytotoxic, antioxidant, anti-inflammatory, antiviral, enzyme inhibitory, and immunosupressive effects.

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Section: Phloroglucinol-based Meroterpenoidsmentioning

confidence: 99%

Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology

et al. 2021

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“…Compounds 3 and 4 downregulated the expression of VEGFR-1 and vimentin proteins. Several reported phenols and sesquiterpene quinones inhibited VEGFR expression [37][38][39][40]. We consider that hydroxyl groups play an important role in inhibiting VEGFR expression.…”

Section: Discussionmentioning

confidence: 81%

Meroterpenoids from Marine Sponge Hyrtios sp. and Their Anticancer Activity against Human Colorectal Cancer Cells

Wang,

Yan,

et al. 2024

Marine Drugs

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Two new meroterpenoids, hyrtamide A (1) and hyrfarnediol A (2), along with two known ones, 3-farnesyl-4-hydroxybenzoic acid methyl ester (3) and dictyoceratin C (4), were isolated from a South China Sea sponge Hyrtios sp. Their structures were elucidated by NMR and MS data. Compounds 2–4 exhibited weak cytotoxicity against human colorectal cancer cells (HCT-116), showing IC50 values of 41.6, 45.0, and 37.3 μM, respectively. Furthermore, compounds 3 and 4 significantly suppressed the invasion of HCT-116 cells while also downregulating the expression of vascular endothelial growth factor receptor 1 (VEGFR-1) and vimentin proteins, which are key markers associated with angiogenesis and epithelial–mesenchymal transition (EMT). Our findings suggest that compounds 3 and 4 may exert their anti-invasive effects on tumor cells by inhibiting the expression of VEGFR-1 and impeding the process of EMT.

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“…Guajadial, a meroterpenoid isolated from P. guajava leaves, was shown to exhibit antineoplastic activity against non-small-cell lung carcinoma, inhibiting the proliferation and migration of the A549 and H1650 lung cancer cell lines. The research also showed that guajadial suppresses A549 tumor growth in xenograft mice [ 57 ]. From the crude dichloromethane guava leaf extract by Rizzo et al, an enriched guajadial fraction was obtained via sequential chromatography.…”

Section: Anticancer Effects Of the Psidium Guajava ...mentioning

confidence: 99%

The Anticancer Potential of Psidium guajava (Guava) Extracts

Lok

Babu

Tabana

et al. 2023

Life

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The fruits, leaves, and bark of the guava (Psidium guajava) tree have traditionally been used to treat a myriad of ailments, especially in the tropical and subtropical regions. The various parts of the plant have been shown to exhibit medicinal properties, such as antimicrobial, antioxidant, anti-inflammatory, and antidiabetic activities. Recent studies have shown that the bioactive phytochemicals of several parts of the P. guajava plant exhibit anticancer activity. This review aims to present a concise summary of the in vitro and in vivo studies investigating the anticancer activity of the plant against various human cancer cell lines and animal models, including the identified phytochemicals that contributes to their activity via the different mechanisms. In vitro growth and cell viability studies, such as the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, the sulforhodamine B (SRB) assay, and the trypan blue exclusion test, were conducted using P. guajava extracts and their biomolecules to assess their effects on human cancer cell lines. Numerous studies have showcased that the P. guajava plant and its bioactive molecules, especially those extracted from its leaves, selectively suppress the growth of human cancer cells without cytotoxicity against the normal cells. This review presents the potential of the extracts of P. guajava and the bioactive molecules derived from it, to be utilized as a feasible alternative or adjuvant treatment for human cancers. The availability of the plant also contributes towards its viability as a cancer treatment in developing countries.

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Guajadial inhibits NSCLC growth and migration following activation of the VEGF receptor-2

Cited by 8 publications

References 15 publications

Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology

Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology

Meroterpenoids from Marine Sponge Hyrtios sp. and Their Anticancer Activity against Human Colorectal Cancer Cells

The Anticancer Potential of Psidium guajava (Guava) Extracts

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