Guaiacol peroxidase levels in human cervical mucus: A possible predictor of ovulation

Tsibris, John C.M.; Thomason, Jessica L.; Kunigk, Annette; Khan-Dawood, Firyal S.; Kirschner, Carolyn V.; Spellacy, William N.

doi:10.1016/0010-7824(82)90019-1

Cited by 10 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The uterine fluid of estrogenprimed rats contains a peroxidase which can utilize the H202 generated by L. acidophilus to kill Escherichia coli (18) or spermatozoa (19) in the presence of a halide ion. Peroxidase activity has been demonstrated in human cervical mucus (3) and in endometrium and endocervical epithelium (11,31,32). The peroxidase of human cervical mucus has been partially purified (26).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of hydrogen peroxide-producing Lactobacillus species in normal women and women with bacterial vaginosis

et al. 1989

View full text Add to dashboard Cite

A predominance of Lactobacillus species in the vaginal flora is considered normal. In women with bacterial vaginosis, the prevalence and concentrations of intravaginal Gardnerella vaginalis and anaerobes are increased, whereas the prevalence of intravaginal Lactobacillus species is decreased. Because some lactobacilli are known to produce hydrogen peroxide (H2O2), which can be toxic to organisms that produce little or no H2O2-scavenging enzymes (e.g., catalase), we postulated that an absence of H2O2-producing Lactobacillus species could allow an overgrowth of catalase-negative organisms, such as those found among women with bacterial vaginosis. In this study, H2O2-producing facultative Lactobacillus species were found in the vaginas of 27 (96%) of 28 normal women and 4 (6%) of 67 women with bacterial vaginosis (P less than 0.001). Anaerobic Lactobacillus species (which do not produce hydrogen peroxide) were isolated from 24 (36%) of 67 women with bacterial vaginosis and 1 (4%) of 28 normal women (P less than 0.001). The production of H2O2 by Lactobacillus species may represent a nonspecific antimicrobial defense mechanism of the normal vaginal ecosystem.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of hydrogen peroxide-producing Lactobacillus species in normal women and women with bacterial vaginosis

et al. 1989

View full text Add to dashboard Cite

show abstract

“…Oral contraceptives, also protective against PID [65], inhibit ovulation, without which the normal cyclic changes in cervical mucus Spinnbarkeit do not occur; the mucus remains too thick for sperm to penetrate readily [66,67]. Even women using rhythm contraception, because they avoid intercourse near the time of ovulation when the cervical mucus is easily penetrable by sperm, may be protected to some extent against PID.…”

Section: Conduct Of Epidemiologic Studiesmentioning

confidence: 99%

Pelvic inflammatory disease, intrauterine contraception, and the conduct of epidemiologic studies

Bj¹

1985

Adv Contracept

View full text Add to dashboard Cite

Pelvic inflammatory disease (PID) has been described in the medical literature for more than a century as a specific entity. Neisseria gonorrhoeae, Chlamydia trachomatis, and Mycoplasma hominis, along with Bacteroides fragilis and other anaerobic bacteria, have been most frequently associated with PID. Factors affecting the occurrence of PID have been extensively studied during the past two decades and include number of sexual partners, age, race, socioeconomic status, education, and contraceptive method. As knowledge concerning factors that contribute to PID increases, epidemiologic studies addressing such issues must become increasingly sophisticated, and the literature needs to be re-evaluated in light of present knowledge. Various risk factors for PID, types of epidemiologic studies, methods for conducting such studies, and data interpretation are reviewed.

show abstract

“…It would help to answer whether uterine growth could occur without an accompanying increase in peroxidase content and also whether peroxidase is a truly specific marker of estrogen-stimulated tissue changes (1 2). In humans, uterine peroxidase activity decreases around ovulation and may be useful as a predictor of this event in fertility control (13,14).…”

Section: Introductionmentioning

confidence: 98%

Estrogen–androgeri interaction: selective inhibition of estrogen-induced uterine peroxidase by testosterone and 5α-dihydrotestosterone

Jellinck¹,

Affleck²,

Newcombe³

1983

Can. J. Biochem. Cell Biol.

View full text Add to dashboard Cite

The effect of testosterone (T) and dihydrotestosterone (DHT) on the induction of peroxidase and glucose-6-phosphate dehydrogenase (G6PDH) in the immature rat uterus by estradiol (E2) was investigated. T (0.5-12.5 mg/rat) given on 3 successive days produced a large increase in uterine weight but, in contrast to E2, did not induce peroxidase or significantly augment uterine G6PDH. However, this androgen, even at a very low dose (50 micrograms/rat three times), inhibited the induction of peroxidase without a corresponding effect on G6PDH when given concurrently with E2 and was more effective than DHT. Inhibition by androgen was also observed when diethylstilbestrol was used to stimulate uterine growth. Combined treatment with E2 (3 micrograms/rat) and T (3 mg/rat) produced a cytosolic and nuclear estrogen receptor pattern in the uterus similar to that observed with E2 alone after various time intervals. The results speak against a direct inhibitory action or T on E2-induced uterine peroxidase via the estrogen receptor and confirm the lack of aromatization of T to E2 in the immature rat. Possible mechanisms for modifying the action of estrogens by androgens are discussed, particularly in the light of E2-induced eosinophilia. It is proposed that steroid hormones can interact in several ways and that uterine peroxidase provides a useful indicator to study steroid hormone action.

show abstract

Guaiacol peroxidase levels in human cervical mucus: A possible predictor of ovulation

Cited by 10 publications

References 12 publications

Prevalence of hydrogen peroxide-producing Lactobacillus species in normal women and women with bacterial vaginosis

Prevalence of hydrogen peroxide-producing Lactobacillus species in normal women and women with bacterial vaginosis

Pelvic inflammatory disease, intrauterine contraception, and the conduct of epidemiologic studies

Estrogen–androgeri interaction: selective inhibition of estrogen-induced uterine peroxidase by testosterone and 5α-dihydrotestosterone

Contact Info

Product

Resources

About