GSTP1, GSTM1, and GSTT1 genetic polymorphisms in patients with cryptogenic liver cirrhosis

The influence of genetic variation in oxidative stress genes on human noise susceptibility

“…These include polymorphic large deletions causing inactivation of two antioxidant genes, GSTM1 and GSTT1, that have previously been associated with several conditions where oxidative stress has been implicated. These include various forms of cancer (Strange et al, 2001), multiple sclerosis (Mann et al, 2000), ParkinsonÕs disease (Tan et al, 2000), asthma (Ivaschenko et al, 2002), and liver cirrhosis (Ghobadloo et al, 2004). For each of 5 other antioxidant genes, where no inactivating polymorphisms were present, several single nucleotide polymorphisms were used.…”

Glutathione S-transferases activity in patients with colorectal cancer

“…The results showed significant correlation between tumor tissue GSTs activity with the corresponding normal tissues. It is well known that there is a GSTs isoenzyme genetic polymorphism difference in patients [15,16,17], and this correlation between tumor and normal tissue in each person may confer susceptibility of each patient to inducing GSTs activity. The availability of tissue biopsy and blood samples from patients undergoing colonoscopy is useful for determining a disease marker.…”

Cryptogenic Cirrhosis: What Are We Missing?

“…Cryptogenic cirrhosis has also been described in a patient with hypocholesterolemia and an abnormal truncated form of apolipoprotein B and in families afflicted with short telomere syndromes associated with pulmonary fibrosis [74,75]. Other reported associations include polymorphisms of glutathione S-transferase and cytokeratin eight in cryptogenic cirrhosis [76,77]. Finally, recent associations between NASH and heavy exposure to some industrial toxins (toxin-associated steatohepatitis-TASH) raise the possibility of toxin-induced cirrhosis as an occupational hazard.…”