GST polymorphism and cytogenetic changes in lung tissues of lung cancer patients

Чакова, Н. Н.; Михаленко, Е. П.; Polonetskaya, S. N.; Chebotareva, N. V.; Demidchik, Yu.; Zhilko, A. A.; Kvitko, O. V.; Krupnova, E. V.

doi:10.3103/s0095452709010071

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…It is known that GST family members (including GSTM2) catalyze the conjugation of various different compounds with the endogenous tripeptide glutathione (GSH) to form the phase II antioxidative enzymes 26 and cytosolic GSTs are divided into six isozymes α (A), μ (M), ω (O), π (P), θ (T), and ξ (X) 26–28. Many studies reported that polymorphism of GSTP1, GSTM1, and GSTT1 and their interaction with other relevant markers influence the genesis or development of cancer, including colorectal 29, breast 30, lung 31, bladder 32, liver 33, and prostate cancer 34. In ovarian cancer, GSTP in cyst fluid has been suggested as a good diagnostic marker for aggressive ovarian tumor 35.…”

Section: Discussionmentioning

confidence: 99%

Proteomic analysis of mesenchymal stem‐like cells derived from ovarian teratoma: Potential role of glutathione S‐transferase M2 in ovarian teratoma

et al. 2011

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Ovarian teratoma is a dermoid cyst in the ovary that contains mature tissues such as hair, teeth, bone, thyroid, etc. To understand the molecular mechanisms of ovarian teratoma growth, a comparative proteomic analysis was undertaken using mesenchymal stem cell-like cells (MSCLCs) isolated from normal human ovarian or teratoma tissues. Both normal ovarian and teratoma MSCLCs expressed stem cell markers OCT4 and NANOG, and were negatively staining with the senescence-associated (SA) β-galactosidase. Furthermore, teratoma MSCLCs had higher proliferation and colony formation rates, with more angiogenic property than that of normal MSCLCs. Proteomic study revealed that 17 proteins had the expression changes over eightfold in ovarian teratoma MSCLCs compared with normal control. Interestingly, among them, GSTM2 was strongly expressed in teratoma MSCLCs. Moreover, overexpressed GSTM2 in the teratoma was associated with downregulation of p38 MAPK and activation of AKT and survivin. Taken together, these findings suggest that that ovarian teratoma MSCLCs have a higher potency for proliferation and angiogenesis and GSTM2 appears to be involved in the regulation of other survival genes.

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Section: Discussionmentioning

confidence: 99%

Proteomic analysis of mesenchymal stem‐like cells derived from ovarian teratoma: Potential role of glutathione S‐transferase M2 in ovarian teratoma

et al. 2011

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“…Following amplification, PCR products were digested with ApaI (rs762551), MvaI (rs3892097), Alw26I (rs1695), KpnI (rs1799929), TaqI (rs1799930), BamHI (rs1799931), MboI (rs1045642) (Fermentas, Lithuania). The GSTT1 and GSTM1 gene polymorphisms were examined using multiplex PCR out according to the technique described earlier [9].…”

Section: Methodsmentioning

confidence: 99%

Polymorphisms of Drug-Metabolizing Enzymes Cyp1a2, Cyp2d6, Gst, Nat2 and Transporter Mdr1 in Population of Belarus: Comparison With Selected European and Asian Populations

Mikhalenka

Chebotareva

Krupnova

et al. 2016

EUREKA: Life Sciences

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Drug therapeutic efficiency and development of unfavorable pharmacologic responses as well as the disease predisposition are caused first of all by patient’s genetic features. Genetic variations in genes encoding drug-metabolizing enzymes and transporter proteins are essential to understand the ethnic differences in disease occurrence, development, prognosis, therapeutic response and toxicity of drugs. For that reason, it is necessary to establish the normative frequency distribution of genotypes and alleles of these genes in a particular population. Data on frequency of pharmacogenetic polymorphisms in the of Belarus population are limited. The goal of our investigation was to analyze the frequency distribution of genotypes and alleles of genes encoding drug-metabolizing enzymes (CYP1А2, CYP2D6 – I phase; GSTs, NAT2 – II phase) and transporter protein MDR1 in the population of Belarus and comparisons with other ethnic populations. Our results indicate that clinically important genes are genetically highly variable and differ considerably between populations. Differences in allele frequencies across continents should be considered when designing clinical trials of new drugs continents should be considered when designing clinical trials of new drugs.

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Susceptibility to the cytogenetic effects of dichloromethane is related to the glutathione S-transferase theta phenotype

et al. 2010

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GST polymorphism and cytogenetic changes in lung tissues of lung cancer patients

Cited by 6 publications

References 9 publications

Proteomic analysis of mesenchymal stem‐like cells derived from ovarian teratoma: Potential role of glutathione S‐transferase M2 in ovarian teratoma

Proteomic analysis of mesenchymal stem‐like cells derived from ovarian teratoma: Potential role of glutathione S‐transferase M2 in ovarian teratoma

Polymorphisms of Drug-Metabolizing Enzymes Cyp1a2, Cyp2d6, Gst, Nat2 and Transporter Mdr1 in Population of Belarus: Comparison With Selected European and Asian Populations

Susceptibility to the cytogenetic effects of dichloromethane is related to the glutathione S-transferase theta phenotype

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