GS-02 for Dysthymic Disorder

Andrade, Chittaranjan; Aswath, Anitha; Chaturvedi, Santosh K.; Raguram, R.; Murthy, Vasantmeghna S

doi:10.1300/j157v02n01_07

Cited by 4 publications

(6 citation statements)

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“…Accordingly, W. somnifera is an ingredient of many traditional medicine preparations . The plant is used to treat various neurological disorders, geriatric debilities, insomnia, anxiety, stress, and behavior-related problems. , Both clinical − and animal − studies have supported the traditional use of “Ashwagandha” as an antistress and anxiolytic remedy. Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central and peripheral nervous system, and the GABAergic system in the mammalian brain plays a critical role in the regulation of anxiety and stress.…”

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confidence: 99%

Ferulic Acid Esters and Withanolides: In Search of Withania somnifera GABA_A Receptor Modulators

et al. 2019

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Nine compounds, including two undescribed withanolides, withasomniferolides A and B (1 and 2), three known withanolides (3−5), a ferulic acid dimeric ester (6), and an inseparable mixture of three long alkyl chain ferulic acid esters (7− 9), were isolated from a GABA A receptor positive activator methanol extract of the roots of Withania somnifera. The structures of the isolated compounds were elucidated based on NMR, MS, and ECD data analysis. In order to bioassay the single ferulic acid derivatives, compounds 6−9 were also synthesized. The most active compound, docosanyl ferulate (9), was able to enhance the GABA A receptor inhibitory postsynaptic currents with an IC 50 value of 7.9 μM. These results, by showing an ability to modulate the GABA A receptor function, cast fresh light on the biological activities of the secondary metabolites of W. somnifera roots.

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confidence: 99%

Ferulic Acid Esters and Withanolides: In Search of Withania somnifera GABA_A Receptor Modulators

et al. 2019

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“…The decision to cover the functional or non-functional cusp in partial coverage preparations may be due to the amount of remaining dental structure [24,38]. In the present study, the reduction of functional or non-functional cusps was compared, with the result that when the non-functional cusp was prepared, the stress on the functional cusp increased regardless of the type of preparation.…”

Section: Discussionmentioning

confidence: 88%

“…Dental adhesive systems play a vital role in today's restorative dentistry [37]. These adhesive restorations substantially decrease the amount of tooth reduction required during the cavity preparation process, since adhesive restorations do not require extensions for retention [22][23][24][25]. It is important to note that most of the margin of the restoration is placed on the enamel, which serves as an excellent bonding surface for the adhesive system.…”

Section: Discussionmentioning

confidence: 99%

“…The functional (2mm) and non-functional (1.5mm) cusps were reduced considering the specific design of each group. The non-retentive preparation following the natural tooth morphology (2 mm on functional cups, 1.5 mm on non-functional cusp), all angles and walls smooth and rounded [23][24][25][26][27].…”

Section: Methodsmentioning

confidence: 99%

“…Unlike metallic restorations, ceramic restorations with traditional preparations, due to their fragile nature, do not support occlusal loads when they involve the coverage of the cusp of the dental structure [22]. Several studies have offered different designs on the preparation of the cavity, ideal for restorations of partial ceramic covering [23][24][25] as well as for the cement layer polymerization kinetics [25,26].…”

Section: Introductionmentioning

confidence: 99%

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Functional or Nonfunctional Cusps Preservation for Posterior Onlays in Indirect Composite or Glass-Ceramic: 3D FEA Study

Sellan¹,

Campaner²,

Tribst³

et al. 2021

Preprint

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Evidence regarding the effect of the onlay preparation design for different CAD/CAM restorative materials considering the preservation of cusps is lacking. Molars were 3D modeled in four preparation designs for onlay restoration: traditional design with functional cusp coverage (TFC), non-retentive design with functional cusp coverage (NFC), traditional design with non-functional cusp coverage (TNFC), non-retentive design with non-functional cusp coverage (NNFC). Restorations were simulated with two CAD/CAM restorative materials: LD – lithium disilicate (IPS e.max CAD) and RC - resin composite (GrandioBloc). A 100 N axial load was applied to the occlusal surface simulating the centric contact point. Von Mises (VM) and maximum principal (Pmax) stresses were evaluated for restorations, cement layer and dental substrate. The non-retentive preparation design reduced the stress concentration in the tooth structure in comparison to the conventional retentive design. For LD onlays, the stress distribution on the restoration intaglio surface showed that the preparation design as well as the prepared cusp, influenced the stress magnitude. The non-retentive preparation design provided better load distribution in both restorative materials and more advantageous for tooth structure. The resin composite restoration on non-functional cusp is recommended when functional cusp is preserved, in order to associate conservative dentistry and low stress magnitude.

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Herbal medicines in the treatment of psychiatric disorders: a systematic review

Sarris

2007

Phytotherapy Research

137

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This paper reports a critical review of 27 herbal medicines and formulas in treating a broad range of psychiatric disorders (in addition to anxiety and depression), including obsessive-compulsive, seasonal affective, bipolar depressive, psychotic, phobic and somatoform disorders. Ovid Medline, Pubmed and the Cochrane Library were searched for pharmacological and clinical evidence of herbal medicines with psychotropic activity. A forward search of later citations was also conducted. Whilst substantial high-quality evidence exists for the use of kava and St John's wort in the treatment of anxiety and depression respectively, currently there is insufficient robust clinical evidence for the use of many other herbal medicines in psychiatric disorders. Phytotherapies which potentially have significant use in psychiatry, and urgently require more research are Rhodiola rosea (roseroot) and Crocus sativus (saffron) for depression; Passiflora incarnata (passionflower), Scutellaria lateriflora (scullcap) and Zizyphus jujuba (sour date) for anxiety disorders; and Piper methysticum (kava) for phobic, panic and obsessive-compulsive disorders. While depression and anxiety are commonly researched, the efficacy of herbal medicines in other mental disorders requires attention. The review addresses current issues in herbal psychotherapy: herbal safety, future areas of application, the relationship of herbal medicine with pharmaceuticals and the potential prescriptive integration of phytomedicines with synthetic psychotropic medicines. Particular attention is given to clinical and safety issues with St John's wort and kava.

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GS-02 for Dysthymic Disorder

Cited by 4 publications

References 0 publications

Ferulic Acid Esters and Withanolides: In Search of Withania somnifera GABA_A Receptor Modulators

Ferulic Acid Esters and Withanolides: In Search of Withania somnifera GABA_A Receptor Modulators

Functional or Nonfunctional Cusps Preservation for Posterior Onlays in Indirect Composite or Glass-Ceramic: 3D FEA Study

Herbal medicines in the treatment of psychiatric disorders: a systematic review

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GS-02 for Dysthymic Disorder

Cited by 4 publications

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Ferulic Acid Esters and Withanolides: In Search of Withania somnifera GABAA Receptor Modulators

Ferulic Acid Esters and Withanolides: In Search of Withania somnifera GABAA Receptor Modulators

Functional or Nonfunctional Cusps Preservation for Posterior Onlays in Indirect Composite or Glass-Ceramic: 3D FEA Study

Herbal medicines in the treatment of psychiatric disorders: a systematic review

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Ferulic Acid Esters and Withanolides: In Search of Withania somnifera GABA_A Receptor Modulators

Ferulic Acid Esters and Withanolides: In Search of Withania somnifera GABA_A Receptor Modulators