Grundlagenforschung zur Jodtherapie des Auges

Trichtel, F.; Trichtel, H.

doi:10.1007/bf00683551

Cited by 5 publications

(2 citation statements)

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“…Despite several diverging data as found in previous stud ies [6,8] ophthalmo-iontophoresis has been shown to be ef fective in carrying considerable amounts of iodide into the lens. The iodide concentrations are distinctly higher than those obtained by all other application methods.…”

Section: Methodsmentioning

confidence: 71%

“…Several research groups have demonstrated an anti oxidative, oxygen-free-radical-scavenging effect of iodide in vitro [1][2][3][4] and in some 'ex vivo' tests [5], By using the method of iontophoresis, iodine uptake into the eye compartments, especially into the lens, could be ex pected to be high enough to achieve a concentration suffi cient for anticataractogenic effects [6][7][8], Based on these previous studies, the purpose of the present experiments was to determine the iodine concentrations which could be obtained in ocular tissues after iontophoresis. …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Iodine Distribution in a Porcine Eye Model following Iontophoresis

Rieger

Winkler²,

Buchberger³

et al. 1995

Ophthalmologica

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Iodine distribution was studied in isolated porcine eyes after iontophoresis using ¹³¹l-labelled solutions and chemical methods. After a 15-min treatment with a therapeutically used iodine brine, the iodine content in the ocular tissues showed the following rank order: cornea > retina > vitreous body > anterior chamber fluid > lens. Replacement of the brine by 0.15 MNal increased the uptake values in a different way, but the same rank order was maintained. The increase was highest in the cornea (5.6-fold) and only about 2-fold in the lens, nevertheless approaching now the level of 10^––⁴ M, a concentration which was regarded as being optimal for the antioxidant effect of I^––. Among the other eye components, the relatively high iodine enrichment of the retina was remarkable. The data are discussed with respect to a possible protective, antioxidative and OH-scavenging efficacy of I and to previous results in the literature concerning iodine uptake in ocular tissues.

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Section: Methodsmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%