Growth responses of Cassia obtusifolia toward human intestinal bacteria

Sung, Bokyung; Kim, Moo-Key; Lee, Wang-Hyu; Lee, Dong-Heon; Lee, Hoi-Seon

doi:10.1016/j.fitote.2004.03.012

Cited by 28 publications

(17 citation statements)

References 5 publications

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“…Pharmacological studies have revealed that Cassiae semen possesses a variety of biological effects, including anti-hyperlipidemic, anti-diabetic, neuroprotective, hepatoprotective, antimicrobial, anti-oxidant and hypotensive activities (5,90,93,114,115). Extracts and compounds responsible for the pharmacological properties have also been determined, as presented in Table II.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, 1,2-dihydroxyanthraquinone (compound 15) isolated from C. obtusifolia seeds was revealed to inhibit the growth of Clostridium perfringens and E. coli ., indicating that this drug exhibited potent growth-inhibiting activities towards human intestinal bacteria (90). Li et al (91) demonstrated that the chloroform extract of the seeds of C. obtusifolia also exhibited different inhibitory activities against Fusarium oxysporum and B. cinerea (IC 50 values were 0.57 mg/ml and 0.97 mg/ml).…”

Section: Pharmacologymentioning

confidence: 99%

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Cassiae semen: A review of its phytochemistry and pharmacology

Dong

Yin

et al. 2017

Molecular Medicine Reports

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Cassiae semen (Leguminosae), a well-known traditional Chinese medicine, has been used for a number of centuries in areas of Southeast Asia, including Korea, Japan and China. The present review aims to provide updated and comprehensive information, on the botany, phytochemistry and pharmacology of Cassiae semen. The available information on Cassiae semen was collected using several different resources, including classic books on Chinese herbal medicine and a number of scientific databases, including the China Academic Journals full-text database, PubMed, SciFinder, the Web of Science and Science Direct. To date >70 chemical compounds have been isolated from Cassiae semen, and the major components have been determined to be anthraquinones, naphthopyrones and volatile oil. The crude extracts and pure compounds of Cassiae semen have been used as effective agents in preclinical and clinical practice due to their beneficial activities, including antihyperlipidemic, antidiabetic, neuroprotective, hepatoprotective, antibacterial, antioxidant and hypotensive activities. With the body of reported data, it has been suggested that Cassiae semen has convincing medicinal potential. However, the pharmacological mechanisms of the main bioactive compounds and the association between structure and activity require further investigation.

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Section: Discussionmentioning

confidence: 99%

Section: Pharmacologymentioning

confidence: 99%

Cassiae semen: A review of its phytochemistry and pharmacology

Dong

Yin

et al. 2017

Molecular Medicine Reports

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“…1,2-dihydroxyanthraquinone, the other upregulated metabolite in the co-culture of C. disseminatus and S. hirsutum is a natural pigment commonly present in a number of dicotyledon plant families, especially Rubiaceae (Han et al 2001), and is commonly used as a dye, and as a antibacterial, antifungal and anti-leukemic agent (Collin 2001). For example, Sung et al (2004) showed that 1,2-dihydroxyanthraquinone isolated from the seeds of Cassia obtusifolia strongly inhibited the growth of Clostridium perfringens and E. coli.…”

Section: Gas Chromatography-tof-mass Spectrometrymentioning

confidence: 99%

Metabolite profiles of interacting mycelial fronts differ for pairings of the wood decay basidiomycete fungus, Stereum hirsutum with its competitors Coprinus micaceus and Coprinus disseminatus

et al. 2007

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The paper presents the first proof-of principle study of metabolite profiles of the interacting mycelial fronts of a wood decomposer basidiomycete, Stereum hirsutum, paired with two competitor basidiomycetes, Coprinus disseminatus and C. micaceus, using TLC and GC-TOF-MS profiling. GC-TOF-MS profiles were information rich, with a total of 190 metabolite peaks detected and more than 120 metabolite peaks detected per sample. The metabolite profiles were able to discriminate between the interactions of S. hirsutum with the two species of Coprinus. In confrontation with C. micaceus, where S. hirsutum mycelial fronts always overgrew those of C. micaceus, there were down-regulations of metabolites in the interaction zone, compared to monocultures of both S. hirsutum and C. micaceus. In contrast, in pairings with C. disseminatus, whose mycelia overgrew those of S. hirsutum, there were some up-regulations compared with monoculture controls, the majority of the metabolites being characteristic of the S. hirsutum monoculture profile. These differences indicate that up-regulation of metabolites in the mycelia of S. hirsutum may be connected to a defensive role or to stress. The results also show proof of principle for the employment of metabolic profiling for biological discovery studies of metabolites produced by fungi that could be applied to natural product screening programmes.

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“…Haedanghwa (Rosa rugosa) petals promoted the growth of B. breve, but the growth of pathogenic bacteria was inhibited by nearly 50% (30). Accordingly, 1,4-and 1,8-dihydroxyanthraquinones from sickle pod exhibited strong growth-promoting activity on B. bifidum, but inhibited the growth of C. perfringens (31). It has been claimed that intestinal microbiota could metabolize phenolic substances to different compounds which could be retained by bacterial cells.…”

Section: Resultsmentioning

confidence: 99%

Growth stimulation/inhibition effect of medicinal plants on human intestinal microbiota

Phoem

Voravuthikunchai

2012

Food Sci Biotechnol

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This experiment was carried out to determine the growth stimulation/inhibition effect of popular herbal extracts on intestinal microbiota and pathogenic bacteria. A paper disc agar diffusion method was employed for preliminary data. All extracts failed to promote intestinal microbiota growth around the discs. Green tea (Camellia sinensis) and Eleutherine americana did not produce inhibition zones against all intestinal microbiota, but inhibited Gram-positive pathogenic bacteria. All pure compounds, except eleutherin demonstrated antibacterial activity against all bacteria. Growth response of the substances on intestinal microbiota were further investigated by viable counts. Eleutherin from E. americana did not produce antibacterial antagonism against important groups of intestinal microbiota. In contrast, E. americana extract and eleutherin at minimal inhibitory concentration (MIC) and 4 MIC showed significant inhibition on growth of Grampositive pathogenic bacteria. The results indicated that both E. americana extract and eleutherin exerted dual beneficial effects to the host by regulating beneficial bacteria and inhibiting pathogenic bacteria.

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Growth responses of Cassia obtusifolia toward human intestinal bacteria

Cited by 28 publications

References 5 publications

Cassiae semen: A review of its phytochemistry and pharmacology

Cassiae semen: A review of its phytochemistry and pharmacology

Metabolite profiles of interacting mycelial fronts differ for pairings of the wood decay basidiomycete fungus, Stereum hirsutum with its competitors Coprinus micaceus and Coprinus disseminatus

Growth stimulation/inhibition effect of medicinal plants on human intestinal microbiota

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