Growth of Small Tumors

Singh, Arun D.; Bena, James; Mokashi, A; Jacques, R; Rundle, Paul; Rennie, I G

doi:10.1016/j.ophtha.2006.02.044

Cited by 9 publications

(3 citation statements)

References 6 publications

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“…There is a significant disconnect in the literature wherein pathology-confirmed cases [18, 20, 21, 28, 30-32] or tumors with metastatic potential [33-35] do not have associated reported growth rates (with a few exceptions [Table 2]) [6, 19], and the studies with growth rates do not include tumors with pathologic confirmation (without exception) [3, 4, 11, 14]. Therefore, we could extract data regarding growth rates only in 2 pathologic studies [6, 19].…”

Section: Discussionmentioning

confidence: 99%

Small Choroidal Melanoma: Correlation of Growth Rate with Pathology

Raval¹,

Luo²,

Zabor³

et al. 2021

Ocul Oncol Pathol

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Purpose: The aim of the study was to evaluate equivalence of growth rate and pathologic confirmation in small choroidal melanoma (SCM). Design: This study is a case series. Subjects, Participants, and Controls: A total of 61 patients with a choroidal melanocytic tumor of size 5.0–16.0 mm in the largest basal diameter and 1.0–2.5 mm in thickness were classified into the pathology-confirmed group (n = 19), growth-confirmed group (n = 30), and with combined observations (n = 12). Methods: Distribution of clinical variables (age, gender, laterality, tumor dimensions, tumor location, and presence of orange pigment, subretinal fluid, drusen, and retinal pigment epithelial [RPE] atrophy) between the groups was analyzed. Patient and disease characteristics were summarized as the median and interquartile range for continuous variables and the frequency and percentage for categorical variables. Comparisons were made using the Wilcoxon rank sum test for continuous variables and either Fisher’s exact test or the χ2 test for categorical variables with a p value threshold of 0.05 for statistical significance. Growth rate (change in basal dimension/12 months) diagnostic of SCM was quantified. Main Outcome Measures: The primary aim of this study was to test the hypothesis that “growth” was diagnostic of SCM with the secondary aim of quantifying the malignant “growth rate” (growth rate of SCM). Results: The clinical characteristics among all 3 groups were similar except more patients with symptoms (68 vs. 20 vs. 42%, p = 0.004) and juxtapapillary location (p = 0.03) were in the pathology group than in the growth-confirmed group. Those in the combined and growth-confirmed groups had more patients with drusen (11 vs. 60 vs. 50%, p = 0.003) and RPE atrophy (11 vs. 23 vs. 67%, p = 0.003), respectively, than in the pathology group. The median time to detect growth was 9 months (range 3–26 months). The mean growth rate in basal dimension was 1.8 mm/12 months (range, 0.0–7.4 mm; [95% CI: 1.32–2.28]). Conclusions and Relevance: Choroidal melanocytic lesions exhibiting a defined growth rate can be clinically diagnosed as SCM without a need for biopsy.

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Section: Discussionmentioning

confidence: 99%

Small Choroidal Melanoma: Correlation of Growth Rate with Pathology

Raval¹,

Luo²,

Zabor³

et al. 2021

Ocul Oncol Pathol

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“…Because of limited ultrasonographic resolution for small tumors and lack of objective interpretation of the findings, ultrasonography in its current form is not reliable [30, 31]. Intrinsic vascular patterns (indocyanine green angiography and optical coherence tomography) also may be biased by subjective interpretation [32, 33]. It would be ideal if we could biopsy all small tumors, not so much for histopathology or cytology as differentiation between nevus and low-grade spindle melanoma may be difficult on a small sample, but for mutational profiling [34].…”

Section: Intrinsic Featuresmentioning

confidence: 99%

What’s in a Name? Large Choroidal Nevus, Small Choroidal Melanoma, or Indeterminate Melanocytic Tumor

Singh

Grossniklaus

2021

Ocul Oncol Pathol

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“…55,56 The COMS classified small melanomas as tumors with an apical height of 1-3 mm, and a maximal basal diameter between 5 and 16 mm. Singh et al 60 reported on the proposed inclusion criteria for the aforementioned trial. Upon study enrollment, 16 patients (8%) had treatment, while 67 patients (33%) required treatment at follow-up.…”

Section: Small Tumorsmentioning

confidence: 99%