Growth of Human Colorectal Tumor Xenografts in Immunosuppressed Mice Reconstituted with Normal Cells

Kópper, L.; Hanh, Tran Van; C, Hegedüs; Lapis, K.

doi:10.1159/000163816

Cited by 4 publications

(3 citation statements)

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“…Carrageenan administration has been found to affect changes in diverse tissues such as the gastric mucosa [11] and the immune system, the latter revealed by higher take rates in treated mice of human tumor xeno grafts [12]. However, it is the colonic poten tial of carrageenan which is of interest.…”

Section: Discussionmentioning

confidence: 99%

Degraded Carrageenan-Induced Colitis in CF<sub>1</sub> Mice

et al. 1984

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Delivery of 10% carrageen (degraded carrageenan, Glaxo, France) for 10 days in the drinking water to CF₁ mice induced bloody diarrhea, pericryptal inflammation, and marked dilatation of the cecum and ascending colon. Histologically, the mucosa was characterized by distorted crypt architecture, inflammatory infiltration of the lamina propria, and ulceration, conditions which were more pronounced in the proximal colon but were also present in the distal colon. Treatment with hydrocortisone and levamisole reduced the severity of all phases of the reaction. Alterations in colonic epithelial cell proliferation corresponded with the clinical and histopathological findings. Labeling indices (LI) significantly increased over control values in both proximal (12.9 ± 4.9 vs. 7.6 ± 2.9) and distal colon (13.9 ± 5.2 vs. 7.2 ± 2.4), effectively doubling the number of proliferating cells per crypt column in both areas. However, DNA-synthesizing cells extended further upward along the cryptal wall of the proximal colon reflecting greater mucosal damage. Only in the proximal colon did the proliferative compartment (PC) extend to the upper third of the glands, normally not a proliferative zone. Hydrocortisone and levamisole administered concurrently with 10% carrageen were less effective in protecting the proximal colon since LI and numbers of labeled cells per crypt column were consistently lower in the distal colon. Moreover, hydrocortisone alone significantly depressed DNA synthesis only in the distal colon. All distal colonic crypts were not equally protected by administration of hydrocortisone since some continued to express large numbers of proliferating cells and an extended PC, well characterized preneoplastic defects in regulatory control of colonic epithelial cell proliferation. The clinical presentation, histopathology, proliferative alterations, potential premalignancy, and response to pharmaceutic intervention of carrageen-induced colitis in mice support its continued investigation as an animal model for human ulcerative colitis.

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Section: Discussionmentioning

confidence: 99%

Degraded Carrageenan-Induced Colitis in CF<sub>1</sub> Mice

et al. 1984

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“…In the nude mouse with T cell immune deficiency, the residual immune system may be a major mechanism in the inhibition of tumour transplantability. The higher phagocytic activity of macrophages that can be observed in these animals as a possible mechanism to overcome the immunological defect, was shown to play a role in the rejection of heterologous tumour tissue (Kopper et al, 1980(Kopper et al, , 1981Vetvicka et al, 1984;Sharp & Colston, 1984). In addition, nude mice are known to possess a higher natural killer (NK) cell activity as compared to normal mice (Herberman et al, 1975).…”

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confidence: 99%

Corrections and clarifications to "On the distribution of the weighted sum of l independent Rician and Nakagami envelopes in the presence of AWGN"

Karagiannidis

Kotsopoulos

2001

J. Commun. Netw.

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“…The higher phagocytic activity of macrophages that can be observed in these animals as a possible mechanism to overcome the immunological defect, was shown to play a role in the rejection of heterologous tumour tissue (Kopper et al, 1980(Kopper et al, , 1981Vetvicka et al, 1984;Sharp & Colston, 1984). In addition, nude mice are known to possess a higher natural killer (NK) cell activity as compared to normal mice (Herberman et al, 1975).…”

mentioning

confidence: 99%