Enhanced transplantability of human ovarian cancer lines in cyclophosphamide-pretreated nude mice

Nauta, M.M.; Boven, Epie; Schlüper, Hennie M.M.; Erkelens, C. A. M.; Pinedo, H.M.

doi:10.1038/bjc.1986.181

Cited by 5 publications

(1 citation statement)

References 17 publications

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“…In addition, many attempts have been made to further improve the existing success rate with human tumors in animals either by refining the transplantation techniques or by altering the host. For instance, an increased success rate of ovarian tumor lines in nude mice was effected by injecting cyclophosphamide prior to subcutaneous implantation [12,87]. Cyclophosphamide was apparently capable of suppressing further immune response, which was present in the nude mice that caused tissue rejection.…”

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confidence: 99%

Human tumor xenografts as model for drug testing

et al. 1988

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This paper reviews the history of xenografts, the endpoints commonly used to evaluate response and chemotherapeutic results obtained with serially maintained human tumor xenografts from different laboratories, and discusses the potential clinical relevance of the heterotransplant model for cancer chemotherapy. Specifically, an attempt is made to correlate the published xenograft data with the clinical data. Drug testing with different types of xenotransplanted tumors has shown that the response of xenografts obtained in immune-deficient animals is comparable to that in clinical practice. In addition, xenografts of a particular tumor type are able to identify agents of known clinical activity against that disease.

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Section: Take Ratementioning

confidence: 99%