Growth Inhibition of Phaeocystis Globosa Induced by Luteolin-7-O-glucuronide from Seagrass Enhalus acoroides

Zhu, Junkai; Han, Xiao; Chen, Qi; Zhao, Min; Sun, Dawei; Duan, Shunshan

doi:10.3390/ijerph16142615

Cited by 14 publications

(9 citation statements)

References 36 publications

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“…The TCA cycle not only provides energy for life activities but also produces a wide range of intermediate products that are raw materials for biosynthesis of many important substances in the organisms [38]. Therefore, we inferred that the antialgal compound inhibited the growth of algal cells through disturbed the TCA cycle of algal cells, which was consistent with our previous study that mitochondrion where the TCA cycle occurred was seriously damaged by the antialgal compound under transmission electron microscopy [26]. Mitochondria is used to generate energy required for cellular processes by oxidizing organic acids in the TCA cycle [39].…”

Section: Discussionsupporting

confidence: 87%

“…With the outbreak of P. globosa blooms, the application of antialgal compounds to control HABs has become a topic of interest within the scientific community. In our previous study, luteolin-7-O-glucuronide showed great potential as antialgal compound to control HABs [26]. Nevertheless, the antialgal mechanism has not yet been fully elaborated.…”

Section: Discussionmentioning

confidence: 99%

“…Luteolin-7-O-glucuronide is a flavone glycoside found in plants [22,23,24,25]. In our previous study, we discovered that luteolin-7-O-glucuronide extracted from Enhalus acoroides ( E. acoroides ) effectively inhibited the growth of harmful algae species P. globosa with EC 50–96h value of 34.29 μg/mL [26]. Luteolin-7-O-glucuronide possesses anti-microbial, antioxidant, anti-mutagenic, anti-genotoxic, anti-inflammatory, and anti-arthritic activities, which means that its application might be safe for human beings [27,28,29].…”

Section: Introductionmentioning

confidence: 99%

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The Antialgal Mechanism of Luteolin-7-O-Glucuronide on Phaeocystis globosa by Metabolomics Analysis

Zhu

Yang

Duan

et al. 2019

IJERPH

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Antialgal compounds from plants have been identified as promising candidates for controlling harmful algal blooms (HABs). In our previous study, luteolin-7-O-glucuronide was used as a promising algistatic agent to control Phaeocystis globosa (P. globose) blooms; however, its antialgal mechanism on P. globosa have not yet been elaborated in detail. In this study, a liquid chromatography linked to tandem mass spectrometry (LC-MS/MS)-based untargeted metabolomic approach was used to investigate changes in intracellular and extracellular metabolites of P. globosa after exposure to luteolin-7-O-glucuronide. Significant differences in intracellular metabolites profiles were observed between treated and untreated groups; nevertheless, metabolic statuses for extracellular metabolites were similar among these two groups. For intracellular metabolites, 20 identified metabolites showed significant difference. The contents of luteolin, gallic acid, betaine and three fatty acids were increased, while the contents of α-Ketoglutarate and acetyl-CoA involved in tricarboxylic acid cycle, glutamate, and 11 organic acids were decreased. Changes in those metabolites may be induced by the antialgal compound in response to stress. The results revealed that luteolin played a vital role in the antialgal mechanism of luteolin-7-O-glucuronide on P. globosa, because luteolin increased the most in the treatment groups and had strong antialgal activity on P. globosa. α-Ketoglutarate and acetyl-CoA were the most inhibited metabolites, indicating that the antialgal compound inhibited the growth through disturbed the tricarboxylic acid (TCA) cycle of algal cells. To summarize, our data provides insights into the antialgal mechanism of luteolin-7-O-glucuronide on P. globosa, which can be used to further control P. globosa blooms.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Antialgal Mechanism of Luteolin-7-O-Glucuronide on Phaeocystis globosa by Metabolomics Analysis

Zhu

Yang

Duan

et al. 2019

IJERPH

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“…To our knowledge, we are the first to et al, 2006;Jiang et al, 2012;Xiao et al, 2019). Additionally, plant extracts were investigated for algicidal activity including one obtained from pomegranate peel (Xiao et al, 2014;Chen et al, 2019;Zhu et al, 2019). However, this is often performed to find most active fractions and subsequently an active ingredient.…”

Section: Algicidal Activitymentioning

confidence: 99%

Ionic liquids vs. ethanol as extraction media of algicidal compounds from mango processing waste

et al. 2022

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The race for environmentally-safe pesticides and biocides has been showing solutions ranging from pest-pathologic microorganisms to safer botanical extracts that can be incorporated in several formulations. Often linked to high biological activities, fruit residues can be recovered from food processing factories to obtain complex extracts enriched with several bioactive chemicals. Mango (Mangifera indica) fruits are processed into food products in high volumes across the globe and generate a consistent residue that contains, among others, the xanthonoid mangiferin and the flavonoid hyperoside. Both compounds have been linked to several pharmacological and pesticidal activities, although not yet studied for algicidal applications, a current concern specially for antifouling and harmful algae blooms control products. The challenge lies, however, not only on the degree of activity of the natural compounds, but also on the processes necessary to separate, isolate and formulate the bioactive compounds in order to obtain an effective final product. The solvent choice plays an important part regarding the selectivity of the separation and isolation of the main bioactive compounds from the solid waste matrix. Ethanolic mixtures in water have been consolidated recently as a promising extraction medium for flavonoids and xanthonoids, although hindered by solubility limitations. In this paper, aqueous solutions of ionic liquids (ILs) were tested, screened and optimized using Box-Behnken design and Response Surface Methodology to obtain mangiferin and hyperosideenriched extracts. Results showed a greater concentration of mangiferin and hyperoside with 1-octyl-3-methylimidazolium chloride ([C 8 MIm] Cl), when compared to choline acetate and ethanolic extracts using optimized parameters. In terms of sufficiency, solvent selection between ILs and ethanolic extraction media was discussed considering economic and environmental factors. Ethanol/water mango waste extracts were then studied for their activity against Raphidocelis subcapitata microalgae, which showed a higher growth inhibition in comparison to standard solutions of mangiferin and hyperoside, either individually and in a 1:1 mixture. A EC 50 value was found in relative low concentrations of mangiferin and hyperoside (0.015 mg L −1 ) detected in the extract, showcasing a promising approach to the direct use of residuary plant extracts in biocidal formulations.

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“…After Ultraperformance Liquid Chromatography-High Resolution Mass Spectrometry (UPLC-HRMS) analysis, six of twelve chemical constituents were flavonoids, with the predominance of luteolin-7-O-glucide. In another study,Zhu et al (2019) proved that this major compound was one of the antialgal compounds of E. acoroides aqueous extract Pakdel et al (2013). demonstrated that the extracts, exudates and live material of Chara australis act as growth inhibitor of Dolichospermum variabilis, with no biological toxicity against the green alga Scenedesmus quadricauda.…”

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confidence: 98%

Harmful Cyanobacterial Blooms (HCBs): innovative green bioremediation process based on anti-cyanobacteria bioactive natural products

et al. 2020

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Over the last decades, Harmful Cyanobacterial Blooms (HCBs) represent one of the most conspicuous hazards to human health in freshwater ecosystems, due to the uses of the water for drinking, recreation and aquaculture. Cyanobacteria are one of the main biological components in freshwater ecosystems and they may proliferate in nutrients rich ecosystems causing severe impacts at different levels. Therefore, several methods have been applied to control cyanobacterial proliferation, including physical, chemical and biological strategies. However, the application of those methods is generally not very efficient. Research on an eco-friendly alternative leading to the isolation of new bioactive compounds with strong impacts against harmful cyanobacteria is a need in the field of water environment protection. Thus, this paper aims to give an overview of harmful cyanobacterial blooms and reviews the state of the art of studying the activities of biological compounds obtained from plants, seaweeds and microorganisms in the cyanobacterial bloom control.

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Growth Inhibition of Phaeocystis Globosa Induced by Luteolin-7-O-glucuronide from Seagrass Enhalus acoroides

Cited by 14 publications

References 36 publications

The Antialgal Mechanism of Luteolin-7-O-Glucuronide on Phaeocystis globosa by Metabolomics Analysis

The Antialgal Mechanism of Luteolin-7-O-Glucuronide on Phaeocystis globosa by Metabolomics Analysis

Ionic liquids vs. ethanol as extraction media of algicidal compounds from mango processing waste

Harmful Cyanobacterial Blooms (HCBs): innovative green bioremediation process based on anti-cyanobacteria bioactive natural products

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