Growth hormone subnormality in down syndrome

Ragusa, Letizia; Romano, Corrado; Failla, Pinella; Proto, Caterina; Colabucci, F

doi:10.1002/ajmg.1320430529

Cited by 5 publications

(5 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These observations are similar to those made by earlier workers who too reported compromised growth amongst patients with DS when compared with their respective population specific standards (Aburawi et al, 2015; Chandrasekhar & Ramachandran, 2018a, 2018b; Myrelid et al, 2002; Zemel et al, 2015). Support to this could also be drawn from findings of Letizia et al, 2005 who also reported reduced growth velocity in DS children after birth. Growth impairment noticed amongst children with DS may be attributed to effect of concomitant diseases from which they frequently suffer.…”

Section: Discussionmentioning

confidence: 53%

“…Chandrasekhar & Ramachandran, 2018a& Ramachandran, , 2018bMyrelid et al, 2002;Zemel et al, 2015). Support to this could also be drawn from findings of Letizia et al, 2005 Pattern-wise, the patients with DS exhibited great growth disparity when contrasted with their DS counterparts studied in and outside India. Both boys and girls with DS of the present study weighed lighter than their UAE (Aburawi et al, 2015), Swedish (Myrelid et al, 2002), Brazilian (Bertapelli et al, 2014) and American (Zemel et al, 2015) counterparts throughout infancy, childhood, and prepubertal phases of growth.…”

Section: Resultsmentioning

confidence: 88%

See 1 more Smart Citation

Growth charts for weight and height of Indian children with Down syndrome

Bhalla,

Kaur,

Kaur

et al. 2024

American J of Med Genetics Pt A

View full text Add to dashboard Cite

Age and gender specific growth charts for Indian children with Down syndrome (DS) based on longitudinal data have not been published. To establish percentile growth charts for DS children inhabiting northwestern parts of India, body weight and length/height of 1125 (Male: 752, Female: 373) children with DS aged <1 month to 10 years, enrolled from the “Genetics Clinic” were measured at half yearly age intervals in the “Growth Clinic” of the Institute from August 1994 to November 2018. A total of 2089 observations were made on these children using standardized anthropometric techniques and instruments following a prospective mixed‐longitudinal growth research design. Using the LMS method, age and sex‐specific percentile growth charts (<1 month to 10 years) for weight, and length/ height were generated. Unpaired t‐test was used to compare mean growth attainments of study children with those of DS patients representing other population groups as well as their normal Multicentre Growth Reference Study (MGRS and Indian Academy of Pediatrics (IAP) counterparts. The 50th percentile growth curves for both weight and length/height of Indian children with DS demonstrated a regular increase. As compared to their normal MGRS and Indian (IAP) counterparts, the children with DS had lower weight and height attainments. The boys and girls with Down syndrome showed short stature (height < 3rd centile) from the age of 1 year till 10 years and also became underweight beyond 5 years. As compared to their normal counterparts, children with Down syndrome exhibited compromised auxological attainments. The use of growth charts presented herein may be used to compare and monitor growth and nutritional status of Indian children with Down syndrome.

show abstract

Section: Discussionmentioning

confidence: 53%

Section: Resultsmentioning

confidence: 88%

Growth charts for weight and height of Indian children with Down syndrome

Bhalla,

Kaur,

Kaur

et al. 2024

American J of Med Genetics Pt A

View full text Add to dashboard Cite

show abstract

“…One study (three articles) reported on a single child with slightly elevated liver enzymes (22,25,29). Another study reported on mild subclinical hypothyroidism (19). Precocious puberty was observed in one boy 3.4 yrs after GH treatment initiation (24).…”

Section: Adverse Effectsmentioning

confidence: 91%

“…One important study presented height data by using a percentile range for each patient at the start and end points of a GH treatment period (19). Another study presented height data by using growth velocity alone (20).…”

Section: Height Outcomementioning

confidence: 99%

See 1 more Smart Citation

GH treatment in pediatric Down syndrome: a systematic review and mini meta-analysis

et al. 2023

View full text Add to dashboard Cite

ObjectiveTo analyze and determine the safety and efficacy of growth hormone (GH) treatment in Down syndrome (DS) pediatric patients and to weigh ethical aspects involved.DesignSystematic review and mini meta-analysis of the literature.MethodsA search was performed in PubMed, Embase, Scopus, and PsycINFO through August 2022. Eligible studies included those who answered at least one of the following two questions: 1) What is the effect of growth hormone treatment in children with Down syndrome? 2) What are the ethical arguments in favor and against growth hormone treatment for children with Down syndrome? Multiple reviewers independently screened each article for eligibility.ResultsIn total sixteen reports detailed medical effects of GH treatment in pediatric DS patients and eight studies dealt with ethical aspects of GH treatment. Treatment with GH resulted in significantly higher growth velocity in patients with DS. The ethical complexity is great but does not present insurmountable difficulties to the therapeutic option.ConclusionsAs GH treatment is safe and effective for short-term height growth, GH therapy should be considered in long-term treatment of DS children.

show abstract

References

2011

Evo‐Devo of Child Growth

View full text Add to dashboard Cite

Growth hormone subnormality in down syndrome

Cited by 5 publications

References 6 publications

Growth charts for weight and height of Indian children with Down syndrome

Growth charts for weight and height of Indian children with Down syndrome

GH treatment in pediatric Down syndrome: a systematic review and mini meta-analysis

References

Contact Info

Product

Resources

About