Growth Hormone Receptor Expression in Atrophying Muscle Fibers of Rats

Casse, Al Hassan; Desplanches, Dominique; Mayet-Sornay, Marie Hélène; Raccurt, Mireille; Jégou, Sylvie; Morel, Gérard

doi:10.1210/en.2003--0311

Cited by 6 publications

(3 citation statements)

References 32 publications

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“…Transgenic models in mice also indicate that major effects of GH on growth are dependent on IGF-I expression, which requires intact insulin and IGF-I receptor signalling in skeletal muscle (Kim et al, 2005). However, GH regulates other mitogenic factors, and there is now experimental evidence supporting the up-regulated expression of GHRs during muscle repair and maintenance (Casse et al, 2003). In fish, it is believed that genetic duplication and divergence of two GHR subtypes (GHR type I and II) would take place on an early ancestor of fish lineage (Saera-Vila et al, 2005b;Jiao et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Combined replacement of fish meal and oil in practical diets for fast growing juveniles of gilthead sea bream (Sparus aurata L.): Networking of systemic and local components of GH/IGF axis

et al. 2007

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Growth performance and growth regulatory pathways were examined in juvenile gilthead sea bream fed diets containing largely plant-based ingredients. Four isonitrogenous and isolipidic extruded diets with a low level (20%) of fish meal inclusion were formulated with graded levels of a vegetable oil mixture (17:58:25 of rapeseed: linseed: palm oils) replacing fish oil at 33, 66 and 100% (33VO, 66VO and VO diets). All diets were supplemented with lysine (0.55%) and contained soy lecithin (1%). Daily growth coefficients and feed efficiency over the course of an 11-week trial were almost identical in fish fed the FO, 33VO and 66VO diets. The VO diet reduced feed intake and growth without significant effects in proximate whole body composition, nitrogen or energy retentions. The highest concentration of plasma levels of insulin-like growth factor-I (IGF-I) was found in fish fed the 33VO diet. The lowest concentration was attained in fish fed the VO diet, whereas intermediate values were found in fish fed FO and 66VO diets. An opposite trend was found for circulating levels of growth hormone (GH), probably as a result of a reduced negative feedback inhibition from circulating IGF-I. Hepatic expression of IGF-I and GH receptor type I (GHR-I) was regulated in concert and mRNA levels paralleled plasma levels of IGF-I. Hepatic IGF-II and GHR-II were expressed in a more constitutive manner and no changes at the mRNA level were detected. In the skeletal muscle, IGF-I and GHR-I mRNAs did not vary significantly among groups. By contrast, IGF-II mRNA was up-regulated in fish fed the control diet, whereas the highest amount of GHR-II mRNA was attained in fish fed the 66VO diet. All together, these results suggest different growth compensatory mechanisms mediated by IGF-II and GHR-II at the local tissue level. These new insights prompted us to propose that practical diets low in marine ingredients can be used over the productive cycle of gilthead sea bream when essential fatty acids are supplied above the requirement levels.

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Section: Discussionmentioning

confidence: 99%

Combined replacement of fish meal and oil in practical diets for fast growing juveniles of gilthead sea bream (Sparus aurata L.): Networking of systemic and local components of GH/IGF axis

et al. 2007

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“…In addition to mechanical loading-induced expression of local factors, several other components such as albumin, IGF-binding proteins, receptors, cytokines (i.e., TNF-1α, IL-1 and IL-6), calcium and vitamins may modulate the effects of IGF-I and myostatin (Casse et al 2003 ; Clemmons 1998 ; Coletti et al 2005 ; Jaspers et al 2008 ; Ling et al 1997 ; Pfeifer et al 2002 ). For example, insulin receptor phosphorylation, insulin receptor substrate (IRS-2) phosphorylation, as well as the downstream PI3K activity were all shown to be significantly higher in the high oxidative soleus compared to EDL (Song et al 1999 ).…”

Section: Pathways and Stimuli Regulating Protein Turnover In Differenmentioning

confidence: 99%

The muscle fiber type–fiber size paradox: hypertrophy or oxidative metabolism?

et al. 2010

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An inverse relationship exists between striated muscle fiber size and its oxidative capacity. This relationship implies that muscle fibers, which are triggered to simultaneously increase their mass/strength (hypertrophy) and fatigue resistance (oxidative capacity), increase these properties (strength or fatigue resistance) to a lesser extent compared to fibers increasing either of these alone. Muscle fiber size and oxidative capacity are determined by the balance between myofibrillar protein synthesis, mitochondrial biosynthesis and degradation. New experimental data and an inventory of critical stimuli and state of activation of the signaling pathways involved in regulating contractile and metabolic protein turnover reveal: (1) higher capacity for protein synthesis in high compared to low oxidative fibers; (2) competition between signaling pathways for synthesis of myofibrillar proteins and proteins associated with oxidative metabolism; i.e., increased mitochondrial biogenesis via AMP-activated protein kinase attenuates the rate of protein synthesis; (3) relatively higher expression levels of E3-ligases and proteasome-mediated protein degradation in high oxidative fibers. These observations could explain the fiber type–fiber size paradox that despite the high capacity for protein synthesis in high oxidative fibers, these fibers remain relatively small. However, it remains challenging to understand the mechanisms by which contractile activity, mechanical loading, cellular energy status and cellular oxygen tension affect regulation of fiber size. Therefore, one needs to know the relative contribution of the signaling pathways to protein turnover in high and low oxidative fibers. The outcome and ideas presented are relevant to optimizing treatment and training in the fields of sports, cardiology, oncology, pulmonology and rehabilitation medicine.Electronic supplementary materialThe online version of this article (doi:10.1007/s00421-010-1545-0) contains supplementary material, which is available to authorized users.

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“…The extent of muscle atrophy depends on the duration and type of given interventions. For example, relative wet weight loss of the SOL 1 week after denervation was 34% (Sakakima et al, 2000), while those induced by joint immobilization (Herbert et al, 1988) and exposure to microgravity (Casse et al, 2003) for 1 week were 42% and 41%, respectively. In our study, arthritis-induced wet weight loss of the SOL and RF muscles was 19% and 21%, respectively.…”

Section: Muscle Atrophy After Cfa Injectionmentioning

confidence: 98%

Morphological changes in hind limb muscles elicited by adjuvant‐induced arthritis of the rat knee

Ozawa¹,

Kurose²,

Kawamata³

et al. 2010

Scandinavian Med Sci Sports

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We investigated qualitative and quantitative changes in rat hind limb muscles caused by complete Freund's adjuvant (CFA)-induced knee joint pain. One week after CFA injection, muscle atrophy was induced only on the CFA-injected side. Wet weight of the rectus femoris (RF) and soleus (SOL) muscles were significantly decreased by 20% and 19%, respectively. The reduction in cross-sectional areas by CFA was similar for fast and slow muscle fibers in the RF (10% vs 15%, respectively) and SOL muscles (16% vs 16%, respectively). At the light microscopic level, pathological changes were not found in the RF muscles on both sides, although the infiltration of mononuclear cells and muscle regeneration were found in the SOL muscles on CFA-injected and contralateral control sides. On the other hand, electron microscopy revealed degenerative changes in the RF and SOL muscles on the CFA-injected side. Interestingly, sarcomere hypercontraction, indicating overexercise, was observed to a limited extent in the SOL muscles on the control side. In conclusions, knee joint pain can trigger the rapid development of muscle atrophy with degenerative changes not only in thigh but also calf muscles. This indicates that early interventions to inhibit joint pain or inflammation may prevent muscle atrophy.

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Growth Hormone Receptor Expression in Atrophying Muscle Fibers of Rats

Cited by 6 publications

References 32 publications

Combined replacement of fish meal and oil in practical diets for fast growing juveniles of gilthead sea bream (Sparus aurata L.): Networking of systemic and local components of GH/IGF axis

Combined replacement of fish meal and oil in practical diets for fast growing juveniles of gilthead sea bream (Sparus aurata L.): Networking of systemic and local components of GH/IGF axis

The muscle fiber type–fiber size paradox: hypertrophy or oxidative metabolism?

Morphological changes in hind limb muscles elicited by adjuvant‐induced arthritis of the rat knee

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