Growth hormone, prolactin and thyrotrophin responses to thyrotrophin-releasing hormone in diabetic patients

Harrower, A. D. B.

doi:10.1136/pgmj.56.657.481

Cited by 16 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TSH and PRL responses to metoclopramide, an antidopaminergic agent, have been tested to prove this hypothesis [ 18], However, because of its interactions with other ncurotransmitters such as serotonin [20,21,26,34] or acetyl choline [3,12,19,25,26,43], mctoclopramide does not seem to be just an antagonist of dopamine. Furthermore, data in the litera ture describing TSH and PRL alterations in IDDM are scant and often contradictory, since decreased [9,18], increased [1,22] or unchanged [6,10,13,15,24,30,32,33,38,40,42] circulating levels of these hormones have been reported. These discrepancies might be due to inappropriate selection of subjects: in some studies subjects have been chosen without regard to their sex and, in others, regardless of the duration of their dis ease.…”

Section: Introductionmentioning

confidence: 99%

TSH and PRL Responses to Domperidone and TRH in Men with Insulin-Dependent Diabetes Mellitus of Different Duration

Coiro¹,

Butturini²,

Gnudi

et al. 1987

Horm Res

View full text Add to dashboard Cite

The effect of domperidone, a specific blocker of dopamine receptors, on serum TSH and PRL levels was evaluated in 16 euthyroid men affected by insulin-dependent diabetes mellitus (IDDM) of different duration and in 7 age-matched normal controls. Diabetics were divided into 2 groups of 8 men according to the duration of their disease (group I: 1-9 years; group II: 11-18 years). Both groups had normal basal levels of TSH and PRL. Responses of these hormones to domperidone were similar in normal controls and in group I diabetics, whereas they were significantly reduced in patients of group II. When all 16 diabetics were studied together, a significant negative correlation was found between mean maximal peaks of TSH and PRL responses to domperidone and duration of diabetes. In order to evaluate whether the reduced effect of domperidone in diabetics was due to alterations of the dopaminergic control of TSH and PRL secretion, the domperidone test was repeated in 6 normal controls and in 6 diabetics of group II after infusion of dopamine (4 µg/kg/min for 2 h). Dopamine infusion induced parallel decreases in TSH and PRL concentrations, without modifying hormonal secretory patterns in response to domperidone. These data suggested that the reduced TSH and PRL responses to domperidone in diabetics were not due to alterations of the dopaminergic control of pituitary function but to a defect at the pituitary level. To test this hypothesis, TSH and PRL responses to TRH were evaluated in group I and group II diabetics and in normal controls. Results showed reduced TSH and PRL responses in diabetics of group II, but not in those of group I; when all 16 diabetics were studied together, a significant negative correlation was found between maximal peaks of TSH and PRL responses to TRH and duration of diabetes. These data indicate that the acute releasing pools of both TSH and PRL are reduced with time after the onset of IDDM.

show abstract

Section: Introductionmentioning

confidence: 99%

TSH and PRL Responses to Domperidone and TRH in Men with Insulin-Dependent Diabetes Mellitus of Different Duration

Coiro¹,

Butturini²,

Gnudi

et al. 1987

Horm Res

View full text Add to dashboard Cite

show abstract

“…Normal or decreased basal pro¬ lactin Prl (Champeyroux et al 1978;Fr0land et al 1977;Harrower 1980), gonadotrophin (Distiller et al 1975;Djursing et al 1982) and thyrotrophin (TSH) levels (Weeke & Hansen 1974;Schernthaner et al 1981) have been found. This inconsistency may in part be due to inappropriate selection of patients regarding age of the subjects and the time of the menstrual cycle.…”

mentioning

confidence: 99%

Possible altered dopaminergic modulation of pituitary function in normal-menstruating women with insulin dependent diabetes mellitus (IDDM)

Djursing

Carstensen

Hagen

et al. 1984

Acta Endocrinologica

View full text Add to dashboard Cite

In order to assess whether a possible altered dopamine activity in normal-menstruating diabetic patients may influence the pituitary hormone secretion we have measured the basal serum concentrations of Prl, LH and FSH in 28 patients with insulin dependent diabetes mellitus (IDDM) and in 55 normal-menstruating women at day 3 to 6 of the menstrual cycle. In addition basal levels of oestradiol-17\g=b\,TSH, thyroxine (T4), triiodothyronine (T3) and resin-T3 uptake (RT3U) were determined in 17 patients with IDDM and in 17 controls. The responses of FSH, LH, Prl, GH and TSH to metoclopramide (MTC) administration (10 mg iv) were studied in 17 patients and 17 controls. In 10 patients with IDDM and 8 controls the short-term variations in pituitary hormones and blood glucose concentration were evaluated. Patients with IDDM had significantly lower basal levels of Prl (P < 0.01) and TSH (P < 0.05) and significantly (P < 0.05) higher basal levels of GH than normal women. No significant (P > 0.05) differences were found regarding basal serum concentrations of FSH, LH, oestradiol, T4, T3 and RT3U. During the 3 h period the mean coefficient of variation of Prl, FSH, LH and GH was not significantly (P >0.05) different between diabetic patients and controls. Both groups responded significantly (P<0.01) in Prl and TSH to MTC but the TSH response was significantly (P < 0.05) lower in patients with IDDM. The Prl response to MTC was not significantly (P > 0.05) different within the two groups. None of the groups responded significantly (P > 0.05) in GH or gonadotrophins to MTC. No significant correlations (P > 0.05) were found between parameters of diabetes regulation and basal or stimulated hormone concentrations. Although, the interpretation of

show abstract

“…We have not found such an association and our study suggests that factors other than poor glycaemic control must be important: some ofour patients with Type I diabetes were also poorly controlled, as judged by their high mean HbA1 concentrations, yet they had normal TSH (and prolactin) responses. Others have noted normal TSH responses in Type I diabetes (Morley et al, 1978;Harrower, 1980;Leroith et al, 1980;Dasmahapatra et al, 1981;MacFarlane et al, 1982;Salardi et al, 1984) and that improvement of glycaemic control did not alter the TSH responses to TRH (MacFarlane et al, 1982). Despite the occasional presence of antibodies to anterior pituitary cells in Type I diabetes (Bottazzo et al, 1975), dynamic biochemical alterations in thyrotroph and lactotroph function do not seem to occur.…”

Section: Resultsmentioning

confidence: 98%

Impaired thyrotrophin secretion following the administration of thyrotrophin-releasing hormone in type II diabetes mellitus

Small

Cohen

MacLean

et al. 1986

Postgraduate Medical Journal

View full text Add to dashboard Cite

show abstract

Growth hormone, prolactin and thyrotrophin responses to thyrotrophin-releasing hormone in diabetic patients

Cited by 16 publications

References 23 publications

TSH and PRL Responses to Domperidone and TRH in Men with Insulin-Dependent Diabetes Mellitus of Different Duration

TSH and PRL Responses to Domperidone and TRH in Men with Insulin-Dependent Diabetes Mellitus of Different Duration

Possible altered dopaminergic modulation of pituitary function in normal-menstruating women with insulin dependent diabetes mellitus (IDDM)

Impaired thyrotrophin secretion following the administration of thyrotrophin-releasing hormone in type II diabetes mellitus

Contact Info

Product

Resources

About