Growth Hormone Deficiency Associated with Hereditary Multiple Exostoses – Growth Hormone Treatment of One Case

Martinez, Elia; Sanz, Miguel León; Carranzo, F. Hawkins

doi:10.1111/j.1651-2227.1988.tb10840.x

Cited by 3 publications

(1 citation statement)

References 2 publications

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“…Most individuals have at least one or multiple operative procedures (Bovée 2008). Growth hormone treatment has been performed in three cases of multiple osteochondroma (Galasso et al 1996, Martinez et al 2008.…”

Section: Introductionmentioning

confidence: 99%

Clinical and molecular studies of EXT1/EXT2 in Bulgaria

Stancheva-Ivanova

Wuyts

Hul

et al. 2011

J of Inher Metab Disea

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EXT1/EXT2-CDG (Multiple cartilagineous exostoses, hereditary multiple osteochondroma (MO); OMIM 133700/133701) are common defects of O-xylosylglycan glycosylation. The diagnostic criteria are at least two osteochondromas of the juxta-epiphyseal region of long bones with in the majority of cases a positive family history and/or mutation in one of the EXT genes. The authors report data on clinical symptoms and complications of 23 patients (from 16 families), discussing the family history, age of diagnosis, new clinical and molecular data. Fifteen mutations and large deletions, of which nine are new, were detected in the EXT1 and EXT2 gene by sequence analysis, FISH and MLPA analysis.

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Section: Introductionmentioning

confidence: 99%

Clinical and molecular studies of EXT1/EXT2 in Bulgaria

Stancheva-Ivanova

Wuyts

Hul

et al. 2011

J of Inher Metab Disea

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Growth Hormone Therapy in Two Patients with Hereditary Multiple Exostosis

Galasso¹,

Scirè²,

M³

et al. 1996

Clin Pediatr (Phila)

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Hereditary multiple exostoses and solitary osteochondroma associated with growth hormone deficiency: to treat or not to treat?

et al. 2015

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BackgroundOsteochondroma generally occurs as a single lesion and it is not a heritable disease. When two or more osteochondroma are present, this condition represents a genetic disorder named hereditary multiple exostoses (HME). Growth hormone deficiency (GHD) has rarely been found in HME patients and a few data about growth therapy (GH) therapy effects in development/growth of solitary or multiple exostoses have been reported.Case presentationWe describe the clinical features of 2 patients (one with osteochondroma and one with HME) evaluated before and after GH therapy. In the first patient, the single osteochondroma was noticed after the start of treatment; the other patient showed no evidence of significant increase in size or number of lesions related to GH therapy.ConclusionIt is necessary to investigate GH secretion in patients with osteochondroma or HME and short stature because they could benefit from GH replacement therapy. Moreover, careful clinical and imaging follow-up of exostoses is mandatory.

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Growth Hormone Deficiency Associated with Hereditary Multiple Exostoses – Growth Hormone Treatment of One Case

Cited by 3 publications

References 2 publications

Clinical and molecular studies of EXT1/EXT2 in Bulgaria

Clinical and molecular studies of EXT1/EXT2 in Bulgaria

Growth Hormone Therapy in Two Patients with Hereditary Multiple Exostosis

Hereditary multiple exostoses and solitary osteochondroma associated with growth hormone deficiency: to treat or not to treat?

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