Growth Hormone Deficiency – A Case Report

Devkota, A; Upadhyay, Satyam

doi:10.3126/jnps.v31i2.3260

Cited by 1 publication

(2 citation statements)

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“…It is an uncommon genetic condition that stems from a mutation in the GH receptor gene found on chromosome 5's short arm. This defect leads to an inability of the body to respond to GH, which in turn causes growth failure and other symptoms that resemble isolated GH deficiency type 1A [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

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Rare Case of Growth Hormone Insensitivity Syndrome Correlated With Hypothyroidism: A Case Report

Vagha,

Lohiya

et al. 2024

Cureus

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Growth hormone insensitivity syndrome (GHIS) is a rare genetic disorder characterized by short stature due to the body's inability to effectively utilize growth hormone (GH). This case report describes a patient with concurrent hypothyroidism and GHIS. This patient is an 11-year-old female presented with short stature; general examination suggested a prominent forehead and a depressed nasal bridge. Laboratory evaluations revealed elevated thyroid-stimulating hormone (TSH) levels alongside low levels of triiodothyronine (T3) and thyroxine (T4), indicating hypothyroidism. Additionally, elevated GH levels and significantly reduced insulin-like growth factor 1 (IGF-1) levels confirmed the diagnosis of GHIS. The patient was managed with thyroid hormone replacement therapy and recombinant GH. This dual therapeutic approach will lead to improvements in both thyroid function and growth parameters. This case underscores the importance of recognizing and addressing coexisting endocrine disorders in patients with GHIS to optimize their growth and developmental outcomes. Early diagnosis and a comprehensive treatment strategy are essential for managing such complex cases effectively.

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Section: Discussionmentioning

confidence: 99%

“…In 1959, Zvi Laron identified the syndrome in three siblings from a Jewish family with a common ancestry, all displaying pronounced short stature. Despite resembling individuals with hypopituitarism, these siblings had remarkably elevated levels of serum human GH [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Rare Case of Growth Hormone Insensitivity Syndrome Correlated With Hypothyroidism: A Case Report

Vagha,

Lohiya

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

Growth Hormone Deficiency – A Case Report

Cited by 1 publication

References 10 publications

Rare Case of Growth Hormone Insensitivity Syndrome Correlated With Hypothyroidism: A Case Report

Rare Case of Growth Hormone Insensitivity Syndrome Correlated With Hypothyroidism: A Case Report

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