Growth hormone co-treatment within a GnRH agonist long protocol in patients with poor ovarian response: a prospective, randomized, clinical trial

Küçük, Tansu; Kozinoglu, Hakan; Kaba, Ayten

doi:10.1007/s10815-008-9212-7

Cited by 103 publications

(89 citation statements)

References 20 publications

(20 reference statements)

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“…In this study effective dose of gonadotropins, duration of stimulation were significantly lower in the GH co-treatment. Furthermore, Kucuk et al [7] observed an improved ovarian response as well as increased ART success. Despite numerous more recent studies, the applicability of GH co-treatment in IVF/ICSI cycles for poor responders remains controversial [8].…”

Section: Discussionmentioning

confidence: 98%

“…The problem is supposed to be bound with the definition of a poor responder, underpowered statistical analysis, the pooling of patients with diverse additional risk factors such as age and heterogeneous protocols of GH administration, ovarian stimulation and luteal support [9]. However, most studies show that GH treatment usually increases the number of MII stage recovered, the fertilization rate [7], the number of embryos reaching the transfer stage [9], the pregnancy rate [10] and the rate of live births [11]. Another study showed that GH co-treatment within an antagonist protocol in poor responders undergoing IVF/ICSI cycles significantly improved the number of oocytes collected, MII oocytes retrieved, 2 pn zygote and good-quality transferred embryos.…”

Section: Discussionmentioning

confidence: 99%

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Growth hormone co-treatment in IVF/ICSI cycles in poor responders

Obyedkova

Kogan

Krikheli

et al. 2017

Gynecological Endocrinology

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To estimate the efficacy of growth hormone (GH) co-treatment within an antagonist protocol in IVF/ICSI cycles in poor responders. A prospective observational study involving 50 patients underwent a standard antagonist protocol with or without GH co-treatment. GH was administered by a daily subcutaneous injection of 1,33 mg (equivalent to 4 IU) starting from day 1 of ovarian stimulation until the day of 10,000 human chorionic gonadotropin (hCG) triggering . Concentrations of GH, insulin-like growth factor I (IGF-I) and IGF binding protein-3 (IGFBP-3) in serum and follicular fluid were the subject matter of analysis. The GH co-treatment significantly lowered the effective dose of gonadotropins, duration of stimulation, IGFBP-3 level in serum and follicular fluid on the day of oocyte retrieval. The total number of oocytes as well as the number of metaphase II stage (MII) oocytes, two pronucleus (2 pn) zygotes, good-quality transferred embryos was significantly higher in the GH þ group. Pregnancy was achieved in patients GH þ group only. Positive correlation was found between IGF-I level in follicular fluid, dynamics of IGFBP-3 level changes during stimulation protocol and the number of good-quality transferred embryos in the GH þ group. GH administration in IVF/ICSI cycles for poor responders raises ovarian sensitivity to the gonadotropin exogenous influence, increasing number of high-quality embryos and the probability of pregnancy. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Growth hormone co-treatment in IVF/ICSI cycles in poor responders

Obyedkova

Kogan

Krikheli

et al. 2017

Gynecological Endocrinology

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“…Сравнению коротких и длинных протоколов в программах ВРТ посвящено много исследований [4,7,9,10], и в большинстве из них описано преимуще-ство коротких протоколов для пациенток с «бедным ответом». При классическом длинном протоколе су-ществует опасность глубокой десенситизации гипо-физа.…”

Section: Discussionunclassified

Effectiveness of ovarian stimulation in women with reduced ovarian reserve

Shamugiia¹,

Anshina²,

Смирнова³

et al. 2016

Probl. reprod.

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Центр репродукции и генетики «ФертиМед», Москва, Россия; кафедра акушерства и гинекологии Российской медицинской академии последипломного образования, Москва, Россия, 105043Цель исследования -оценить эффективность индукции суперовуляции в протоколах с минидозами агонистов ГнРГ (аГнРГ) у пациенток с низким фолликулярным резервом. Материал и методы. В исследование включены 92 пациентки с низким фолликулярным резервом, у которых проведен ретроспективный анализ результатов ЭКО и ЭКО/ИКСИ. Основную группу (1-я группа) исследования составили 48 пациенток, у которых стимуляция суперовуляции проводилась по длинному протоколу с минидозами аГнРГ. Группу сравнения (2-я группа) составили 44 пациентки с применением антагонистов (ант)ГнРГ. Результаты. Получено значимое превышение частоты наступления клинической беременности в группе пациенток, стимуляцию у которых проводили с минидозами аГнРГ. Выводы. Установлено, что у женщин с прогнозируемым «бедным» ответом на индукцию суперовуляции длинный протокол с минимальными дозами аГнРГ более эффективен по сравнению со стимуляцией антГнРГ. Objective. To evaluate the effectiveness of two different superovulation induction protocols in women with reduced ovarian reserve. Material and methods. The results of superovulaion induction in 92 patients with predicted poor response in IVF programs were studied. Group I consisted of 48 patients who had mini-dose long protocol. The group II consisted of 44 patients who were treated with antagonists GnRH. Results. Pregnancy rate in the group of patients treated with mini-dose aGnRH was significantly higher. Conclusion. It was determined that in comparison with antagonists GnRH, mini-dose long aGnRH stimulation protocol is more effective for women with predicted poor answer. Ключевые слова: бесплодие, ЭКО, индукция суперовуляции, фолликулярный резерв, бедный ответ, аГнРГ. Effectiveness of ovarian stimulation in women with reduced ovarian reserve

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“…Kucuk et al [14], evaluated the efficacy of growth hormone co-stimulation to long luteal GnRHa regimen in poor responders in a RCT. This study stated that poor responder women undergoing repeated assisted reproduction treatment and co-stimulated with GH achieve more oocytes, higher fertilization rate if growth hormone started in the luteal phase of previous cycle, as compared with women of the same status treated with GnRHa long protocol [14].…”

Section: Gh As An Adjuvant In Poor Responders In Ivf Protocolsmentioning

confidence: 99%