“…The clinical decision to treat M2P agenesis associated with the retained 2pm is a challenging issue, 60 and the options to extract, thus allowing space closure, to prosthetically replace the missing tooth or to maintain the primary tooth in the arch implies reflection over various parameters, such as the health of the crown, pulp and the root of the primary tooth as well as of the surrounding bone, 50 the vertical position of the primary tooth relative to the occlusal plane; the presence of ankylosis of the primary tooth, 60 the patient's sagittal and vertical skeletal individual characteristics, 62,88 the occlusal relationships and dental crowding, the patient's dental and chronological age, 62 the presence of third molars, and the patient's preference for specific treatment or the expenditure of money. 29,34,35 Whenever the delayed exfoliation of the 2pm is detected, the diagnosis must necessarily be completed by the radiographic observation and verification of M2P agenesis, 47 as if it occurs, the therapeutic option is an urgent need, and in the majority of the cases, it is a complex therapy.…”