Growth, carcase and meat traits and gene expression in chickens divergently selected for intramuscular fat content

Li, D L; Chen, J L; Wen, Jie; Zhao, Guiping; Zheng, Maiqing; Liu, C

doi:10.1080/00071668.2013.771392

Cited by 18 publications

(17 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This approach identified the gene set that best correlates to IMF% is triacylglyceride (TAG) deposition, and includes FABP4. A number of other groups have identified similar sets of genes in various production species based on similar analyses performed on similar experimental designs (Saez et al, 2009;Li et al, 2013;Wang et al, 2013;Ren et al, 2014). However, to date the simplest measures of DE and correlations of abundance to phenotype have yielded only modest regulatory insight.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal muscle gene expression patterns associated with differential intramuscular fat in cattle

Hudson

Reverter

Greenwood

et al. 2015

Animal

View full text Add to dashboard Cite

Intramuscular fat (IMF) can improve meat product quality through its impact on flavour and juiciness. High marbling cuts can command premium prices in some countries and grading systems, but there is substantial cost involved in choosing to grain feed animals in an effort to deposit more IMF. There would be value in developing methods to predict predisposition to 'marble' well. Unfortunately, the biological mechanisms underpinning marbling remain a mystery: the key adipocyte cell populations have not been defined, there are no reliable DNA markers, no known (if any) causal mutations and gene expression analyses in the main have tended to characterise increases in expression of end-point fat metabolism proteins such as the fatty acid-binding proteins. To shed light on expression-based markers of marbling potential, we contrasted LD gene expression in high IMF Wagyu cross animals with a low IMF Piedmontese cross at various time points. The expected divergence in the fat metabolism genes FABP4, THRSP, CIDEC and ACACA between the breeds occurs surprisingly late in postnatal development at about 20 months. On the other hand, divergent expression of WISP2, RAI14 and CYP4F2 was discovered in animals at or before 12 months of age, suggesting these genes may have potential as earlier predictors of marbling potential. In line with other researchers, we found intriguing links between IMF development and connective tissue remodelling. WISP2 -a novel adipokine highly expressed and secreted by adipose precursor cells and an inhibitor of the pro-fibrotic connective tissue growth factor -emerges as a particularly attractive candidate. It is relatively upregulated in high marbling Wagyu before admission to feedlotting, somewhere between 7 and 12 months. This difference is subsequently maintained until 25 months, but not thereafter. RAI14, thought to play a role in porcine adipocyte differentiation and with links to retinoic acid metabolism, has an unusual expression profile. Its expression level increases monotonically with postnatal development, and is always higher in Wagyu than Piedmontese. Strong, sustained upregulation of the anti-inflammatory CYP4F2 in Piedmontese is consistent with Wagyu adiposity being a pro-inflammatory state. Application of regulatory impact factor analysis, a network method for identifying causal effector molecules, suggests marbling roles for transcription factors previously implicated in (1) the formation of liposarcoma (unconstrained fatty masses) (YEATS4, MDM2), (2) adipogenesis (CREBL2, SP1, STAT1) and (3) inflammation (ISGF3G, HOXB13, PML).

show abstract

Section: Introductionmentioning

confidence: 99%

Longitudinal muscle gene expression patterns associated with differential intramuscular fat in cattle

Hudson

Reverter

Greenwood

et al. 2015

Animal

View full text Add to dashboard Cite

show abstract

“…Broiler breeders have given attention to abdominal fat to improve both meat quality and efficiency of feed conversion (Li et al . ). Previous studies showed that there were no significant differences of IMFC in leg muscle (Ricard et al .…”

Section: Introductionmentioning

confidence: 97%

Selection against abdominal fat percentage may increase intramuscular fat content in broilers

Leng

Zhang

Dong

et al. 2016

J Animal Breeding Genetics

View full text Add to dashboard Cite

Excessive abdominal fat content (AFC) has negative impacts on feed efficiency and carcass quality. Unlike AFC, intramuscular fat content (IMFC) could be a favourable trait, which has a positive impact on meat quality. To meet consumers' needs, a long-term goal of broiler breeders is to decrease AFC and improve the IMFC simultaneously. The current study was designed to investigate the relationship between AFC and IMFC and to compare IMFC, including the pectoral major muscle fat content (PIMFC) and intramuscular fat content of leg muscle (LIMFC), between two broiler lines divergently selected for abdominal fat percentage over 17 generations. The results showed that there was a significant difference in PIMFC and LIMFC between the two lines in all five generation populations used. The birds in the lean line had significantly lower AFC but higher PIMFC and LIMFC than the birds in the fat line. We also detected differences in the liver fat content (LFC) between the two lines and the results showed that birds in the fat line had significant higher LFC than birds in the lean line. Our results indicated that a desirable broiler line with higher IMFC but lower AFC could be obtained by genetic selection.

show abstract

“…This includes fatty acid synthase (FASN) which was found to correlate with meat weight loss during the first salting of dry-cured ham production [143], meat quality including marbling in cattle [144] and playing a role in the mammary gland and milk in goats and cattle [145,146], in addition to many other roles. Differing H-FABP polymorphisms/expression levels have also been related to growth rate and size of beef cattle and chickens and could therefore provide useful markers for breeding [147,148].…”

Section: Future Faty Acid Research and Medicinementioning

confidence: 99%

Fatty Acids in Veterinary Medicine and Research

Simpson¹,

Mostyn²

2017

Fatty Acids

View full text Add to dashboard Cite

Faty acid regulation is an essential process for all animals. A number of studies have shown that diet afects the levels/availability of faty acids in the body but increasingly an evidence shows that disease states can alter the amounts within the body too. Faty acid levels and availability have been altered by a number of diseases, disorders and reactions including inlammatory responses, heart disease and heart failure and wound repair. They are also essential during the growth and development stages of animals. The amount of research into the consequences of diferent faty acid intake and levels in various disease states and during development has increased in both humans and animals. This review presents an overview of the research undertaken to date and highlights the importance, uses and beneits of understanding the roles of faty acids in both the healthy animals and animals under difering disorders and diseases.

show abstract

Growth, carcase and meat traits and gene expression in chickens divergently selected for intramuscular fat content

Cited by 18 publications

References 28 publications

Longitudinal muscle gene expression patterns associated with differential intramuscular fat in cattle

Longitudinal muscle gene expression patterns associated with differential intramuscular fat in cattle

Selection against abdominal fat percentage may increase intramuscular fat content in broilers

Fatty Acids in Veterinary Medicine and Research

Contact Info

Product

Resources

About