Fatty Acids in Veterinary Medicine and Research

Simpson, Siobhan; Mostyn, A

doi:10.5772/intechopen.68440

Cited by 2 publications

(3 citation statements)

References 143 publications

(160 reference statements)

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“…5 Total PUFA = %C18:2 + %C20:3 + %C20:4 + %C22:5 + %C20:5 + %C22:6. 6 SFA/MUFA = (%C14:0 + %C16:0 + %C18:0)/(%C16:1 + %9c,C18:1 + %11c,C18:1). 7 Omega-6/omega-3 ratio = (%C18:2 + %C20:3 + %C20:4 + %C22:5)/(%C20:5 + %C22:6.).…”

Section: The Erythrocyte Membrane Lipidome In Healthy Donkeysmentioning

confidence: 99%

“…It has been demonstrated that fatty acids play a crucial role on the health status of all living organisms, both human and animals [6], with the erythrocyte membrane fatty acid content being the main subject of research in animals through the last years [7,8]. A previous study showed that an altered lipid metabolism can result in the development of metabolic syndrome in equids [9].…”

Section: Introductionmentioning

confidence: 99%

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The Lipidomics of Spermatozoa and Red Blood Cells Membrane Profile of Martina Franca Donkey: Preliminary Evaluation

Prasinou

Amicis²,

Fusaro³

et al. 2022

Animals

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Fatty acid-based lipidomic analysis has been widely used to evaluate health status in human medicine as well as in the veterinary field. In equine species, there has been a developing interest in fertility and sperm quality. Fatty acids, being the principal components of the membranes, play an active role in the regulation of the metabolic activities, and their role on spermiogenesis seems to be of great importance for the resulting quality of the sperm and, thus, fertility. With the application of widely used lipidomic techniques, the aim of this study was to evaluate: a) the fatty acid content of the spermatozoa’s membranes of 26 healthy male Martina Franca donkeys and its possible correlation with sperm parameters, and b) the evaluation of the composition of the red blood cells’ membrane. PUFA omega-6 are the principal components (40.38%) of the total PUFA content (47.79%) in both types of cells; however, DPA is the predominant one on the spermatozoa’s membrane (27.57%) but is not present in the erythrocyte’s membrane. Spermatozoa’s motility (%) is positively correlated with stearic acid and EPA, and progressive motility (%), with oleic acid. These findings offer information on the composition of both types of cells’ membranes in healthy male MF donkeys and reflect the metabolic transformations of the spermatozoa’s membrane during the maturation period, providing a better perception of the role of fatty acids in sperm parameters and fertility.

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Section: The Erythrocyte Membrane Lipidome In Healthy Donkeysmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Lipidomics of Spermatozoa and Red Blood Cells Membrane Profile of Martina Franca Donkey: Preliminary Evaluation

Prasinou

Amicis²,

Fusaro³

et al. 2022

Animals

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“…Limited studies presented a small number of samples (35,36), focusing for example on PUFA (omega-6 and omega-3), and not deepening the different fatty acid families, which are instead important for molecular contribution to membrane homeostasis (37). Although fatty acids are recognized to be crucial for all animals (38), an effort to build up the methodology for fatty-acidbased membrane lipidomics in the veterinary field is missing. In the present work, we evaluated the composition of fatty acids in erythrocyte membrane phospholipids in a group of clinically healthy dogs (n = 68), focusing on the interval ranges of the 10 fatty acid cohort previously used for humans.…”

Section: Introductionmentioning

confidence: 99%

The Erythrocyte Membrane Lipidome of Healthy Dogs: Creating a Benchmark of Fatty Acid Distribution and Interval Values

et al. 2020

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Molecular-based approaches are rapidly developing in medicine for the evaluation of physiological and pathological conditions and discovery of new biomarkers in prevention and therapy. Fatty acid diversity and roles in health and disease in humans are topical subjects of lipidomics. In particular, membrane fatty acid-based lipidomics provides molecular data of relevance in the study of human chronic diseases, connecting metabolic, and nutritional aspects to health conditions. In veterinary medicine, membrane lipidomics, and fatty acid profiles have not been developed yet in nutritional approaches to health and in disease conditions. Using a protocol widely tested in human profiling, in the present study erythrocyte membrane lipidome was examined in 68 clinically healthy dogs, with different ages, sex, and sizes. In particular, a cluster composed of 10 fatty acids, present in membrane glycerophospholipids and representative of structural and functional properties of cell membrane, was chosen, and quantitatively analyzed. The interval values and distribution for each fatty acid of the cluster were determined, providing the first panel describing the healthy dog lipidomic membrane profile, with interesting correlation to bodyweight increases. This molecular information can be advantageously developed as benchmark in veterinary medicine for the evaluation of metabolic and nutritional status in healthy and diseased dogs.

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Fatty Acids in Veterinary Medicine and Research

Cited by 2 publications

References 143 publications

The Lipidomics of Spermatozoa and Red Blood Cells Membrane Profile of Martina Franca Donkey: Preliminary Evaluation

The Lipidomics of Spermatozoa and Red Blood Cells Membrane Profile of Martina Franca Donkey: Preliminary Evaluation

The Erythrocyte Membrane Lipidome of Healthy Dogs: Creating a Benchmark of Fatty Acid Distribution and Interval Values

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