Growth and Regression of the Germfree (Axenic) Thymus.

Wilson, Robert A.; Bealmear, M.; Sobonya, Richard E.

doi:10.3181/00379727-118-29766

Cited by 21 publications

(3 citation statements)

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“…It is not greater after than before birth [58], in conventional animals than in germ-free ones [80,88], and it seems to remain unchanged after antigenic stimulation [57,58]. The exception to these findings is a lipopolysaccharide antigen, the per-tussis vaccine, which can cause a change in thymus cell proliferation [20,21,66].…”

Section: Discussionmentioning

confidence: 98%

Influence of Contact Allergy on Thymus Lymphoid Cell Migration

Linna¹

1970

Int Arch Allergy Immunol

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Section: Discussionmentioning

confidence: 98%

Influence of Contact Allergy on Thymus Lymphoid Cell Migration

Linna¹

1970

Int Arch Allergy Immunol

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“…Wilson et al (343) reported a slightly smaller weight of the thymus in germ-free mice. Bealmear and Wilson (24) observed the lymphocyte population in the thymus of mice to ca.…”

Section: Structure and Function Of Various Organ Systemsmentioning

confidence: 95%

The gnotobiotic animal as a tool in the study of host microbial relationships.

Gordon¹,

Pesti²

1971

Bacteriological Reviews

270

121

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“…The variation in size of the population in response to a conventional environment is also inconsistent with the hypothesis of a bursal equivalent. The known central or primary lymphoid organs in vertebrates, namely the thymus and the bursa of Fa bricius, appear to develop independently of antigenic stimulation, their ontogeny being similar qualitatively, and to a large extent quantitatively, in both germ-free and conventional animals [Thorbecke et al, 1957;W ilson et al, 1965;U no et al, 1968;Kruml et al, 1969].…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting the Lymphoid Cells in the Small Intestinal Epithelium of the Mouse

Glaister¹

1973

Int Arch Allergy Immunol

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The ontogeny of the lymphoid cells in conventional and germ-free mice has been studied. Development is similar in both groups up to the age of 4 weeks. During the first 2 weeks of neonatal life, few cells are present, but the numbers increase rapidly between 2 and 4 weeks of age. The number of cells continues to increase in conventional mice, but remains static in germ-free mice. Exposing adult germ-free mice to a conventional environment results in an increase in the size of the epithelial lymphocyte population to that characteristic of conventional mice. Rearing conventional weanling mice on antibiotic-treated drinking water does not prevent the post-weaning increase in lymphoid cell numbers. The results are interpreted as showing that the lymphoid cell population in the intestinal epithelium is part of the second-level or peripheral lymphoid tissue rather than part of the first-level systems such as the thymus and bursa of Fabricius.

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Growth and Regression of the Germfree (Axenic) Thymus.

Cited by 21 publications

References 0 publications

Influence of Contact Allergy on Thymus Lymphoid Cell Migration

Influence of Contact Allergy on Thymus Lymphoid Cell Migration

The gnotobiotic animal as a tool in the study of host microbial relationships.

Factors Affecting the Lymphoid Cells in the Small Intestinal Epithelium of the Mouse

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