The gnotobiotic animal as a tool in the study of host microbial relationships.

Gordon, H A; Pesti, L

doi:10.1128/mmbr.35.4.390-429.1971

Cited by 270 publications

(126 citation statements)

References 107 publications

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“…It is only known that some components of the autochthonous g.i. microbiota can stimulate non-specific immunity, either systemically [59,[79][80][81][82] or locally [18,[81][82][83][84][85][86][87][88] or both systemically and locally [82,89,90]. Autochthonous gut bacteria can also stimulate specific immunity [91][92][93][94][95] anO induce specific immunological tolerance [60,92,94,[96][97][98].…”

Section: Possible Beneficial Effects Of Sfbsmentioning

confidence: 99%

Intestinal, segmented, filamentous bacteria

Klaasen

1992

FEMS Microbiology Letters

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Section: Possible Beneficial Effects Of Sfbsmentioning

confidence: 99%

Intestinal, segmented, filamentous bacteria

Klaasen

1992

FEMS Microbiology Letters

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“…Commensal bacteria have been shown to be active participants in the development of the structure and function of host tissues (Gordon and Pesti, 1971;Umesaki and Setoyama, 2000;Hooper et al, 2001;Xu and Gordon, 2003;Macpherson and Harris, 2004). For example, commensal bacteria are required for the complete development of Peyer's patches, the lamina propria and the intraepithelial spaces, all three of the main immune elements found in the intestine (Duncan and Edberg, 1995;Falk et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Commensal bacteria-dependent select expression of CXCL2 contributes to periodontal tissue homeostasis

et al. 2013

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Summary The oral and intestinal host tissues both carry a heavy microbial burden. Although commensal bacteria contribute to healthy intestinal tissue structure and function, their contribution to oral health is poorly understood. A crucial component of periodontal health is the recruitment of neutrophils to periodontal tissue. To elucidate this process, gingival tissues of specific‐pathogen‐free and germ‐free wild‐type mice and CXCR2KO and MyD88KO mice were examined for quantitative analysis of neutrophils and CXCR2 chemoattractants (CXCL1, CXCL2). We show that the recruitment ofneutrophils to the gingival tissue does not require commensal bacterial colonization but is entirely dependent on CXCR2 expression. Strikingly, however, commensal bacteria selectively upregulate the expression of CXCL2, but not CXCL1, in a MyD88‐dependent way that correlates with increased neutrophil recruitment as compared with germ‐free conditions. This is the first evidence that the selective use of chemokine receptor ligands contributes to neutrophil homing to healthy periodontal tissue.

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“…The content of the cecum and intestines are fluid, and the animal is said to have a chronic mild diarrhea. In addition, aside from low levels of antigenic material in the feed and bedding, the immune system of the GF rat is unstimulated (Gordon and Pesti, 1971). The lamina propria is thin and almost devoid of antibody-producing plasma cells, and lymph nodes are smaller (Gordon and Wostmann, 1960;Gordon et al, 1966).…”

Section: Production Of Defined Microbiome Ratsmentioning

confidence: 99%