Growth and Fat-Free Mass Gain in Preterm Infants After Discharge: A Randomized Controlled Trial

Roggero, Paola; Giannì, Maria Lorella; Amato, Orsola; Liotto, Nadia; Morlacchi, Laura; Orsi, Anna; Piemontese, Pasqua; Taroni, Francesca; Morniroli, Daniela; Bracco, Beatrice; Mosca, Fabio

doi:10.1542/peds.2012-1193

Cited by 31 publications

(44 citation statements)

References 20 publications

(21 reference statements)

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“…24 Furthermore, also the growth of head circumference in the first six months of life is better in infants fed with PDF than standard formula. 25 Some clinicians suggest that babies should receive PDF at least until a post-conceptional age of 40 weeks, but possibly until about 52 weeks of post-conceptional age. 13,26 So, short term advantages of PDF are demonstrated but on the contrary, at age 8 years no differences were found in body size, body composition, bone variables and metabolic health variables when comparing infants fed with PDF with those fed with standard formulas.…”

Section: Human Milkmentioning

confidence: 99%

Nutritional management of preterm newborn after hospital discharge: energy and nutrients

2017

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Preterm infants are at risk for poor growth while in the Neonatal Intensive Care Unit (NICU) and after discharge from the NICU. The main objective is to reach the body composition and rate of growth of a normal fetus/infant of the same post-menstrual age during the first entire year of life. In case of human milk, the limited data do not provide convincing evidence that feeding preterm infants after discharge with multi-nutrient fortified human milk, compared with unfortified, affects important outcomes including growth rates during infancy. Conversely, if formula-fed, post discharge formulas produce short term advantages in growth rate but no long term advantages are demonstrated. It is very important to establish a feeding plan and a follow up for all preterm babies who are discharged from NICU in order to recognize as soon as possible any growth deficit.

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Section: Human Milkmentioning

confidence: 99%

Nutritional management of preterm newborn after hospital discharge: energy and nutrients

2017

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“…However, protein intake in the neonatal period will not necessarily have an impact on growth indices in childhood (59). A high protein intake in the in-hospital as well as in the post discharge period seems to decrease fat mass and increase lean mass up to 6 mo corrected age (61)(62)(63). Whether this trend persists into childhood is not known.…”

Section: The Role Of Dietary Proteins In Growth and Body Compositionmentioning

confidence: 99%

Dietary proteins and IGF I levels in preterm infants: determinants of growth, body composition, and neurodevelopment

2014

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“…Furthermore, Roggero et al (11) described beneficial effects of a nutrient-enriched formula compared with a standard TF on gain in head circumference and LM in the first 6 mo of life in preterm infants born with an appropriate size for their gestational age (GA).…”

Section: Introductionmentioning

confidence: 99%

Follow-up of a randomized trial on postdischarge nutrition in preterm-born children at age 8 y

Ruys¹,

Lagemaat²,

Finken

et al. 2017

The American Journal of Clinical Nutrition

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Background: Early nutritional interventions may modulate health risks in preterm-born infants. Previously, we showed that pretermborn infants fed an isocaloric protein-and mineral-enriched postdischarge formula (PDF) from term age to 6-mo corrected age (CA) gained more lean mass than did those fed term formula (TF). Longterm follow-up of randomized nutritional trials is important to test the hypothesis that short-term positive effects on health are sustainable. Objective: The aim of this follow-up study was to compare body size, body composition, and metabolic health at age 8 y in pretermborn children who were randomly assigned to receive either PDF or TF from term age until 6-mo CA. Design: A total of 79 of 152 children (52%) from the original randomized controlled trial were enrolled for follow-up at age 8 y. Weight, height, and head circumference were measured by using standard methods. Body composition, including fat mass, lean mass, bone mineral content, and bone mineral density, was determined by dual-energy X-ray absorptiometry. Blood pressure was measured in the supine position by using an automatic device. Metabolic variables, including glucose, insulin, insulin-like growth factor I, triglycerides, cholesterol, cortisol, and leptin, were measured after an overnight fast. Nutritional habits at age 8 y were assessed by using a 3-d nutritional diary. Results: At age 8 y, no differences were found in body size, body composition, bone variables, and metabolic health variables when comparing children fed PDF with those fed TF. Adjustment for known and possible confounders did not change these results. Conclusions: In this follow-up study in preterm-born children, we showed that the favorable effects of PDF at 6-mo CA either were not maintained or could not be confirmed because of attrition at the age of 8 y. We suggest that future research should focus on nutritional interventions in the pre-and postdischarge period as a continuum rather than as separate entities. This trial was registered at www.trialregister.nl as NTR 2972 (follow-up study [STEP-2 (Study Towards the Effects of Post-discharge Nutrition 2)]) and NTR 55 [original randomized controlled trial (STEP)].Am J Clin Nutr 2017;106:549-58.

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Growth and Fat-Free Mass Gain in Preterm Infants After Discharge: A Randomized Controlled Trial

Abstract: This randomized controlled trial demonstrates the beneficial effect of the consumption of a nutrient-enriched formula after hospital discharge by AGA infants both in terms of head circumference growth and fat-free mass gain.

Cited by 31 publications

References 20 publications

Nutritional management of preterm newborn after hospital discharge: energy and nutrients

Nutritional management of preterm newborn after hospital discharge: energy and nutrients

Dietary proteins and IGF I levels in preterm infants: determinants of growth, body composition, and neurodevelopment

Follow-up of a randomized trial on postdischarge nutrition in preterm-born children at age 8 y

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